Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients

Neuroscience Letters

Volumn 244, Issue 3, 1998, Pages 165-168

  Nagai, Makiko ^a   Abe, Koji ^a   Okamoto, Koichi ^b   Itoyama, Yasuto ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Alternative splicing; Amyotrophic lateral sclerosis; GLT 1; Spinal cord

Indexed keywords

GLUTAMIC ACID; MESSENGER RNA;

ADULT; ALTERNATIVE RNA SPLICING; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MALE; MOTOR NEURON DISEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD;

AGED; ALTERNATIVE SPLICING; AMINO ACID TRANSPORT SYSTEM X-AG; AMYOTROPHIC LATERAL SCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; FEMALE; HUMANS; MALE; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RNA, MESSENGER; SPINAL CORD;

EID: 0032549709     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00158-X     Document Type: Article

References (20)

1. Aoki, M., Ogasawara, M., Matsubara, Y., Narisawa, K., Nakamura, S., Itoyama, Y. and Abe, K., Mild ALS in Japan associated with novel SOD mutation, Nat. Genet., 5 (1993) 323-324.
2. Arriza, J.L., Fairman, W.A., Wadiche, J.I., Murdoch, G.H., Kavanaugh, M.P. and Amara, S.G., Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex, J. Neurosci., 14 (1994) 5559-5569.
3. Bristol, L.A. and Rothstein, J.D., Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex, Ann. Neurol., 39 (1996) 676-679.
4. Bruijin, L.I., Becher, M.W., Lee, M.K., Anderson, K.L., Jenkins, N.A., Copeland, N.G., Sisodia, S.S., Rothstein, J.D., Borchelt, D.R., Price, D.L. and Cleveland, D.R., ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions, Neuron, 18 (1997) 327-338.
5. Deng, H.-X., Hentati, A., Tainer, J.A., Iqbal, Z., Cayabyab, A., Hung, W.-Y., Getzoff, E.D., Hu, P., Herzfeldt, B., Roos, R.P., Warner, C., Deng, G., Soriano, E., Smyth, C., Parge, H.E., Armed, A., Roses, A.D., Hallewell, R.A., Pericak-Vance, M.A. and Siddique, T., Amyotrophic lateral sclerosis and structural defects in Cu/Zn superoxide dismutase, Science, 261 (1993) 1047-1051.
6. Figlewicz, D.A., Krizus, A. and Martinoli, M.G., Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis, Hum. Mol. Genet., 3 (1994) 1757-1761.
7. Lin, G., Bristol, L.A. and Rothstein, J.D., An abnormal mRNA leads to downregulation of glutamate transporter EAAT2 (GLT-1) expression in familial amyotrophic lateral sclerosis, Ann. Neurol., 40 (1996) 540-541.
8. Manfras, B.J., Rudert, W.A., Trucco, M. and Boehm, B.O., Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas, Biochim. Biophys. Acta, 1195 (1994) 185-188.
9. Meyer, T., Speer, A., Meyer, B., Sitte, W., Kuther, G. and Ludolph, A.C., The glial glutamate transporter complementary DNA in patients with amyotrophic lateral sclerosis, Ann. Neurol., 40 (1996) 456-459.
10. Meyer, T., Ludolph, A.C., Morkel, M., Hagemeier, C. and Speer, A., Genomic organization of the human excitatory amino acid transporter gene GLT-1, NeuroReport, 8 (1997) 775-777.
11. Nakayama, T., Kawakami, H., Tanaka, K. and Nakamura, S., Expression of three glutamate transporter subtype mRNAs in human brain regions and peripheral tissues, Mol. Brain Res., 36 (1996) 189-192.
12. Rosen, D.R., Siddique, T., Patterson, D., Figlewicz, D.A., Sapp, P., Hentani, A., Donaldoson, D., Goto, J., O'Regan, J.P., Deng, H.-X., Rahmani, Z., Krizus, A., McKenna-Yasek, D., Cayabyab, A., Gaston, S.M., Berger, R., Tanzi, R.E., Halperin, J.J., Herzfeldt, B., Van den Bergh, R., Hung, W.-Y., Bird, T., Deng, G., Mulder, D.W., Smyth, C., Laing, N.G., Soriano, E., Pericak-Vance, M.A., Haines, J., Roulesu, G.A., Gusella, J.S., Horvitz, H.R. and Brown, R.H. Jr., Mutations in Cu/Zn superoxide dismutase are associated with familial amyotrophic lateral sclerosis, Nature, 362 (1993) 59-62.
13. Rothstein, J.D., Tsai, J. and Kunel, R.W., Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis, Ann. Neurol., 28 (1990) 18-25.
14. Rothstein, J.D., Martin, L.J. and Kunel, R.W., Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis, New Engl. J. Med., 326 (1992) 1464-1468.
15. Rothstein, J.D., Martin, L.J., Levey, A.I., Dykes-Hoberg, M., Jin, L., Wu, D., Nash, N. and Kunel, R.W., Localization of neuronal and glial glutamate transporter, Neuron, 13 (1994) 713-725.
16. Rothstein, J.D., Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis, Clin. Neurosci., 3 (1996) 348-359.
17. Shashidharan, P., Wittenberg, I. and Plaitakis, A., Molecular cloning of human brain glutamate/aspartate transporter, Biochim. Biophys. Acta, 1191 (1994) 393-396.
18. Shaw, P.J., Ince, P.G., Falkous, G. and Mantle, D., Oxidative damage to protein in sporadic motor neuron disease spinal cord, Ann. Neurol., 38 (1995) 691-695.
19. Smith, R.G., Siklos, L., Alexianu, M.E., Engelhardt, J.I., Mosier, D.R., Colom, L., Mohamed, A.M. and Appel, S.H., Autoimmunity and ALS, Neurology, 47 (Suppl. 2) (1996) S40-S46.
20. Vogel, G., Faulty protein linked to ALS, Science, 274 (1996) 1612-1613.