On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex

Journal of Medicinal Chemistry

Volumn 48, Issue 9, 2005, Pages 3231-3238

  Xiao, Xiangshu ^a   Antony, Smitha ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; INDENO[1,2 C]ISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; BASE PAIRING; CALCULATION; CRYSTAL STRUCTURE; ELECTRICITY; ENANTIOMER; ENERGY; MOLECULAR MODEL; QUANTUM MECHANICS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DNA; DNA TOPOISOMERASES, TYPE I; ELECTROSTATICS; INDENES; INTERCALATING AGENTS; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUANTUM THEORY; THERMODYNAMICS;

EID: 18244362068     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050017y     Document Type: Article

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