Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 446-457

  Strumberg, Dirk ^b   Pommier, Yves ^b   Paull, Kenneth ^b   Jayaraman, Muthusamy ^a   Nagafuji, Pamela ^a   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (3 CARBOXY 1 PROPYL) 5,6 DIHYDRO 5,11 DIKETO 11H INDENO[1,2 C]ISOQUINOLINE; 6 ALLYL 5,6,12,13 TETRAHYDRO 2,3 DIMETHOXY 8,9 (METHYLENEDIOXY) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 6 ETHYL 2,3 DIMETHOXY 8,9 (METHYLENEDIOXY) 11H INDENO[1,2 C]ISOQUINOLINIUM CHLORIDE; 6 ETHYL 5,6,12,13 TETRAHYDRO 2,3 DIMETHOXY 8,9 (METHYLENEDIOXY) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; DNA TOPOISOMERASE INHIBITOR; INTERCALATING AGENT; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DNA; DNA PRIMERS; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR CELLS, CULTURED;

EID: 0033047992     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9803323     Document Type: Article

References (24)

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