Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline

Journal of Organic Chemistry

Volumn 69, Issue 22, 2004, Pages 7495-7501

  Xiao, Xiangshu ^a   Antony, Smitha ^b   Kohlhagen, Glenda ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL METHODS; DNA; ISOMERS; KETONES; NITROGEN; TUMORS;

CYTOTOXITIES; LACTAM NITROGEN;

AROMATIC COMPOUNDS;

9 [3' (4 METHOXYPHENYL)PROPYLIDENE]FLUORENONE; 9 FLUOREDENE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE INHIBITOR; INDENE DERIVATIVE; INDENOISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; LACTAM; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; BASE PAIRING; CANCER CELL CULTURE; CONTROLLED STUDY; DISSOCIATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTHALPY; HUMAN; HUMAN CELL; HYDROGEN BOND; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FLUORENES; HUMANS; ISOQUINOLINES; MODELS, MOLECULAR; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 6344294795     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo048808f     Document Type: Article

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