Structural impact of the leukemia drug 1-β-D-Arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12461-12466

  Chrencik, Jill E ^a   Burgin, Alex B ^b   Pommier, Yves ^c   Stewart, Lance ^b   Redinbo, Matthew R ^a,d  

^a University of North Carolina at Chapel Hill   (United States)

^b DeCODE Chemistry & Biostructures   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES; GENETIC ENGINEERING; HYDROGEN BONDS; TUMORS;

STRUCTURAL IMPACT;

DNA;

3' PHOSPHOTYROSINE; ANTILEUKEMIC AGENT; CYTARABINE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; OLIGONUCLEOTIDE; TYROSINE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; DNA;

ACUTE LEUKEMIA; ANIMAL CELL; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA HELIX; DNA PROTEIN COMPLEX; DNA STRAND; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; CRYSTALLOGRAPHY; ENZYME INDUCTION; LEUKEMIA; PROTEIN TERTIARY STRUCTURE;

ANIMALIA; ARA;

ANTIMETABOLITES, ANTINEOPLASTIC; BINDING SITES; CRYSTALLOGRAPHY; CYTARABINE; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INDUCTION; HUMANS; LEUKEMIA; PROTEIN STRUCTURE, TERTIARY;

EID: 0038485624     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212930200     Document Type: Article

References (41)

1. Champoux, J. J. (2001) Annu. Rev. Biochem. 70, 369-413
2. Wang, J. C. (1996) Annu. Rev. Biochem. 65, 635-692
3. Stewart, L., Redinbo, M. R., Qiu, X., Hol, W. G., and Champoux, J. J. (1998) Science 279, 1534-1541
4. Pommier, Y., Pourquier, P., Fan, Y., and Strumberg, D. (1998) Biochim. Biophys. Acta 1400, 83-105
5. Holden, J. A. (2001) Curr. Med. Chem. Anti-Cancer Agents 1, 1-25
6. Hsiang, Y. H., Hertzberg, R., Hecht, S., and Liu, L. F. (1985) J. Biol. Chem. 260, 14873-14878
7. Hertzberg, R. P., Caranfa M. J., and Hecht S. M. (1989) Biochemistry 28, 4629-4638
8. Staker, B. L., Hjerrild, K., Feese M. D., Behnke C. A., Burgin A. B., and Stewart L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15387-15392
9. Pourquier, P., Ueng, L. M., Kohlhagen, G., Mazumder, A., Gupta, M., Kohn, K. W., and Pommier, Y. (1997) J. Biol. Chem. 272, 7792-7796
10. Pourquier, P., Bjornsti, M. A., and Pommier, Y. (1998) J. Biol. Chem. 273, 27245-27249
11. Pourquier, P., Ueng, L. M., Fertala, J., Wang, D., Park, H. J., Essigmann, J. M., Bjornsti, M. A., and Pommier, Y. (1999) J. Biol. Chem. 274, 8516-8523
12. Pourquier, P., Takebayashi, Y., Urasaki, Y., Gioffre, C., Kohlhagen, G., and Pommier, Y. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1885-1890
13. Lesher, D-T. T., Pommier Y., Stewart L., and Redinbo, M. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 12102-12107
14. Grant, S. (2002) Adv. Cancer Res. 72, 197-233
15. Mastrianni, D. M., Tung N. M., and Tenen, D. G. (1992) Am. J. Med. 92, 286-295
16. Collins, A. R. S. (1977) Biochim. Biophys. Acta 478, 461-473
17. Schweitzer, B. I., Mikita T. Kellogg G. W., Gardner K. H., and Beardsley, G. P. (1994) Biochemistry 33, 11460-11475
18. Gao, Y.-G., van der Marel G. A., van Boom J. H., and Wang, A. H. J. (1991) Biochemistry 30, 9922-9931
19. Redinbo, M. R., Stewart, L., Kuhn, P., Champoux, J. J., and Hol, W. G. (1998) Science 279, 1504-1513
20. Redinbo, M. R., Stewart, L., Champoux, J. J., and Hol, W. G. (1999) J. Mol. Biol. 292, 685-696
21. Redinbo, M. R., Champoux, J. J., and Hol, W. G. (2000) Biochemistry 39, 6832-6840
22. Burgin, A. B. (2001) Methods Mol. Biol. 95, 119-128
23. Burgin, A., Huizenga B., and Nash, H. (1995) Nucleic Acids Res. 23, 2973-2979
24. Krogh, B. O., Cheng C., Burgin A., and Shuman, S. (1999) Virology 264, 441-451
25. Burgin, A., and Nash, H. (1995) Curr. Biol. 5, 1312-1321
26. Hwang, Y., Park M., Fischer W. H., Burgin A., and Bushman, F. (1999) Virology 262, 479-491
27. Krogh, B. O., and Shuman, S. (2000) Mol. Cell 5, 1035-1041
28. Kazmierczak, R. A. Swalla B., Burgin A., Gumport R. I., and Gardner, J. F. (2002) Nucleic Acids Res. 30, 5193-5204
29. Stewart, L., Ireton, G. C., and Champoux, J. J. (1997) J. Mol. Biol. 269, 355-372
30. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
31. Navaza, J. (2001) Acta Crystallogr. Sect. D. Biol. Crystallogr. 57, 1367-1372
32. Yeates, T. O. (1988) Acta Crystallogr. Sect. A 44, 142-144
33. Brunger, A. T. (1993) Acta Crystallogr. Sect. D. Biol. Crystallogr. D49, 24-36
34. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
35. Esnouf, R. M. (1999) Acta Crystallogr. Sect. D. Biol. Crystallogr. 55, 938-940
36. Kraulis, P. J (1991) J. Appl. Crystallogr. 24, 946-950
37. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
38. Pourquier, P., and Pommier, Y. (2001) Adv. Cancer Res. 80, 189-216
39. Thibaudeau, C., Plavec J., Watanabe K. A., and Chattopadhyaya, J. (1994) J. Chem. Soc. Chem. Commun. 537-540
40. Fertala, J., Vance, J. R., Pourquier, P., Pommier, Y., and Bjornsti, M. A. (2000) J. Biol. Chem. 275, 15246-15253
41. Grant, S. (1997) Front. Biosc. 2, 242-252