Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5712-5724

  Nagarajan, Muthukaman ^a   Xiao, Xiangshu ^a   Antony, Smitha ^b   Kohlhagen, Glenda ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; ACID ANHYDRIDE; CAMPTOTHECIN DERIVATIVE; CYTOTOXIC AGENT; DNA TOPOISOMERASE INHIBITOR; INDENOISOQUINOLINE; LACTAM; MONOAMINE; POLYAMINE; SCHIFF BASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DNA CLEAVAGE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR MODEL; MOLECULAR STABILITY; POLYMERIZATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDENES; ISOQUINOLINES; LACTAMS; MODELS, MOLECULAR; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0346996356     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030313f     Document Type: Article

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