The p53 response: Emerging levels of co-factor complexity

Biochemical and Biophysical Research Communications

Volumn 331, Issue 3, 2005, Pages 778-785

  Coutts, Amanda S ^a   La Thangue, Nicholas B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC STIMULATING PROTEIN 1; APOPTOTIC STIMULATING PROTEIN 2; ARF PROTEIN; ATM PROTEIN; DACTINOMYCIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; NUCLEAR PROTEIN; NUCLEOPHOSMIN; ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN JMY; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P300; PROTEIN P53; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; DNA DAMAGE; DRUG HALF LIFE; HUMAN; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; TETRATRICOPEPTIDE REPEAT; TRANSACTIVATION;

EID: 18144371656     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.150     Document Type: Review

References (96)

1. M. Ljungman, and D. Lane Transcription-guarding the genome by sensing DNA damage Nat. Rev. Cancer 4 2004 727 737
2. T. Soussi, and C. Beroud Assessing TP53 status in human tumours to evaluate clinical outcome Nat. Rev. Cancer 1 2001 233 240
3. S.B.-B. Zhou, and S.J. Elledge The DNA damage response: putting checkpoints in perspective Nature 408 2000 403 439
4. D.W. Meek The p53 response to DNA damage DNA Repair 3 2004 1049 1056
5. A.M. Bode, and Z. Dong Post-translational modification of p53 in tumorigenesis Nat. Rev. Cancer 4 2004 793 805
6. S.N. Jones, A.E. Roe, L.A. Donehower, and A. Bradley Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 Nature 378 1995 206 208
7. R. Montes de Oca Luna, D.S. Wagner, and G. Lozano Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 Nature 378 1995 203 206
8. Y. Haupt, R. Maya, A. Kazaz, and M. Oren Mdm2 promotes the rapid degradation of p53 Nature 387 1997 296 299
9. M.H.G. Kubbutat, S.N. Jones, and K.H. Vousden Regulation of p53 stability by Mdm2 Nature 387 1997 299 303
10. J. Momand, G.P. Zambetti, D.L. George, and A.J. Levine The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 69 1992 1237 1245
11. T.W. Joseph, A. Zaika, and U.M. Moll Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage FASEB J. 17 2003 1622 1630
12. Y. Barak, T. Juven, R. Haffner, and M. Oren mdm2 expression is induced by wild type p53 activity EMBO J. 12 1993 461 468
13. S. de Rozieres, R. Maya, M. Oren, and G. Lozano The loss of mdm2 induces p53 mediated apoptosis Oncogene 19 2000 1691 1697
14. C.J. Sherr The INK4a/ARF network in tumour suppression Nat. Rev. Mol. Cell. Biol. 2 2001 731 737
15. S.W. Lowe, and C.J. Sherr Tumor suppression by Ink4a-Arf: progress and puzzles Curr. Opin. Genet. Dev. 13 2003 77 83
16. Y. Xu Regulation of p53 responses by post-translational modifications Cell Death Differ. 10 2003 400 403
17. M. Ashcroft, Y. Taya, and K.H. Vousden Stress signals utilize multiple pathways to stabilize p53 Mol. Cell. Biol. 20 2000 3224 3233
18. M.V. Poyurovsky, X. Jacq, C. Ma, O. Karni-Schmidt, P.J. Parker, M. Chalfie, J.L. Manley, and C. Prives Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization Mol. Cell 12 2003 875 887
19. M.A. Lohrum, M. Ashcroft, M.H. Kubbutat, and K.H. Vousden Identification of a cryptic nucleolar-localization signal in MDM2 Nat. Cell Biol. 2 2000 179 181
20. R. Bernardi, P.P. Scaglioni, S. Bergmann, H.F. Horn, K.H. Vousden, and P.P. Pandolfi PML regulates p53 stability by sequestering Mdm2 to the nucleolus Nat. Cell Biol. 6 2004 665 672
21. S. Kurki, K. Peltonen, L. Latonen, T.M. Kiviharju, P.M. Ojala, D. Meek, and M. Laiho Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation Cancer Cell 5 2004 465 475
22. S. Kurki, L. Latonen, and M. Laiho Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization J. Cell Sci. 116 2003 3917 3925
23. J.D. Weber, L.J. Taylor, M.F. Roussel, C.J. Sherr, and D. Bar-Sagi Nucleolar Arf sequesters Mdm2 and activates p53 Nat. Cell Biol. 1 1999 20 26
24. M.A. Lohrum, R.L. Ludwig, M.H. Kubbutat, M. Hanlon, and K.H. Vousden Regulation of HDM2 activity by the ribosomal protein L11 Cancer Cell 3 2003 577 587
25. Y. Zhang, G.W. Wolf, K. Bhat, A. Jin, T. Allio, W.A. Burkhart, and Y. Xiong Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway Mol. Cell. Biol. 23 2003 8902 8912
26. A. Jin, K. Itahana, K. O'Keefe, and Y. Zhang Inhibition of HDM2 and activation of p53 by ribosomal protein L23 Mol. Cell. Biol. 24 2004 7669 7680
27. M.S. Dai, S.X. Zeng, Y. Jin, X.X. Sun, L. David, and H. Lu Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition Mol. Cell. Biol. 24 2004 7654 7668
28. V. Marechal, B. Elenbaas, J. Piette, J.C. Nicolas, and A.J. Levine The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes Mol. Cell. Biol. 14 1994 7414 7420
29. A. Shvarts, W.T. Steegenga, N. Riteco, T. van Laar, P. Dekker, M. Bazuine, R.C. van Ham, W. van der Houven van Oordt, G. Hateboer, A.J. van der Eb, and A.G. Jochemsen MDMX: a novel p53-binding protein with some functional properties of MDM2 EMBO J. 15 1996 5349 5357
30. S. Tanimura, S. Ohtsuka, K. Mitsui, K. Shirouzu, A. Yoshimura, and M. Ohtsubo MDM2 interacts with MDMX through their RING finger domains FEBS Lett. 447 1999 5 9
31. M.W. Jackson, and S.J. Berberich MdmX protects p53 from Mdm2-mediated degradation Mol. Cell. Biol. 20 2000 1001 1007
32. H. Kawai, D. Wiederschain, H. Kitao, J. Stuart, K.K. Tsai, and Z.M. Yuan DNA damage-induced MDMX degradation is mediated by MDM2 J. Biol. Chem. 278 2003 45946 45953
33. D. Danovi, E. Meulmeester, D. Pasini, D. Migliorini, M. Capra, R. Frenk, P. de Graaf, S. Francoz, P. Gasparini, A. Gobbi, K. Helin, P.G. Pelicci, A.G. Jochemsen, and J.C. Marine Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity Mol. Cell. Biol. 24 2004 5835 5843
34. M. Avantaggiati, V. Ogryzko, K. Gardner, A. Giordano, A.S. Levine, and A.K. Kelly Recruitment of p300/CBP in p53-dependent signal pathways Cell 89 1997 1175 1184
35. W. Gu, X.L. Shi, and R.G. Roeder Synergistic activation of transcription by CBP and p53 Nature 387 1997 819 823
36. N.L. Lill, S.R. Grossman, D. Ginsberg, J. DeCaprio, and D.M. Livingston Binding and modulation of p53 by p300/CBP coactivators Nature 387 1997 823 827
37. D.M. Scolnick, N.H. Chehab, E.S. Stavridi, M.C. Lien, L. Caruso, E. Moran, S.L. Berger, and T.D. Halazonetis CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein Cancer Res. 57 1997 3693 3696
38. C.W. Lee, T.S. Sorensen, N. Shikama, and N.B. La Thangue Functional interplay between p53 and E2F through co-activator p300 Oncogene 16 1998 2695 2710
39. H.M. Chan, and N.B. La Thangue p300/CBP proteins: HATs for transcriptional bridges and scaffolds J. Cell Sci. 114 2001 2363 2373
40. L. Liu, D.M. Scolnick, R.C. Trievel, H.B. Zhang, R. Marmorstein, T.D. Halazonetis, and S.L. Berger p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage Mol. Cell. Biol. 19 1999 1202 1209
41. P.F. Lambert, F. Kashanchi, M.F. Radonovich, R. Shiekhattar, and J. Brady Phosphorylation of p53 serine 15 increases interaction with CBP J. Biol. Chem. 273 1998 33048 33053
42. N.A. Barlev, L. Liu, N.H. Chehab, K. Mansfield, K.G. Harris, T.D. Halazonetis, and S.L. Berger Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases Mol. Cell 8 2001 1243 1254
43. W. Gu, and R.G. Roeder Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 90 1997 595 606
44. A. Ito, C.H. Lai, X. Zhao, S. Saito, M.H. Hamilton, E. Appella, and T.P. Yao p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2 EMBO J. 20 2001 1331 1340
45. Z.M. Yuan, Y. Huang, T. Ishiko, S. Nakada, T. Utsugisawa, H. Shioya, Y. Utsugisawa, K. Yokoyama, R. Weichselbaum, Y. Shi, and D. Kufe Role for p300 in stabilization of p53 in the response to DNA damage J. Biol. Chem. 274 1999 1883 1886
46. A. Ito, Y. Kawaguchi, C.H. Lai, J.J. Kovacs, Y. Higashimoto, E. Appella, and T.P. Yao MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation EMBO J. 21 2002 6236 6245
47. Y. Jin, S.X. Zeng, H. Lee, and H. Lu MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation J. Biol. Chem. 279 2004 20035 20043
48. S.R. Grossman, M. Perez, A.L. Kung, M. Joseph, C. Mansur, Z.X. Xiao, S. Kumar, P.M. Howley, and D.M. Livingston p300/MDM2 complexes participate in MDM2-mediated p53 degradation Mol. Cell 2 1998 405 415
49. R. Wadgaonkar, and T. Collins Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression J. Biol. Chem. 274 1999 13760 13767
50. E. Kobet, X. Zeng, Y. Zhu, D. Keller, and H. Lu MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins Proc. Natl. Acad. Sci. USA 97 2000 12547 12552
51. X. Wang, J. Taplick, N. Geva, and M. Oren Inhibition of p53 degradation by Mdm2 acetylation FEBS Lett. 561 2004 195 201
52. N. Shikama, C.W. Lee, S. France, L. Delavaine, J. Lyon, M. Krstic-Demonacos, and N.B. La Thangue A novel cofactor for p300 that regulates the p53 response Mol. Cell 4 1999 365 376
53. C. Demonacos, M. Krstic-Demonacos, and N.B. La Thangue A TPR motif cofactor contributes to p300 activity in the p53 response Mol. Cell 8 2001 71 84
54. C. Demonacos, M. Krstic-Demonacos, L. Smith, D. Xu, D.P. O'Connor, M. Jansson, and N.B. La Thangue A new effector pathway links ATM kinase with the DNA damage response Nat. Cell Biol. 6 2004 968 976
55. S.L. Berger Histone modifications in transcriptional regulation Curr. Opin. Genet. Dev. 12 2002 142 148
56. M.R. Stallcup Role of protein methylation in chromatin remodeling and transcriptional regulation Oncogene 20 2001 3014 3020
57. W. An, J. Kim, and R.G. Roeder Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 Cell 117 2004 735 748
58. W.Y. Chan, Q.R. Liu, J. Borjigin, H. Busch, O.M. Rennert, L.A. Tease, and P.K. Chan Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth Biochemistry 28 1989 1033 1039
59. C.P. Rubbi, and J. Milner Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses EMBO J. 22 2003 6068 6077
60. M.H. Wu, and B.Y. Yung UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA J. Biol. Chem. 277 2002 48234 48240
61. E. Colombo, J.C. Marine, D. Danovi, B. Falini, and P.G. Pelicci Nucleophosmin regulates the stability and transcriptional activity of p53 Nat. Cell Biol. 4 2002 529 533
62. D.A. Maiguel, L. Jones, D. Chakravarty, C. Yang, and F. Carrier Nucleophosmin sets a threshold for p53 response to UV radiation Mol. Cell. Biol. 24 2004 3703 3711
63. A. Kakizuka, W.H. Miller Jr., K. Umesono, R.P. Warrell Jr., S.R. Frankel, V.V. Murty, E. Dmitrovsky, and R.M. Evans Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML Cell 66 2001 663 674
64. H. de The, C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR Cell 66 2001 675 684
65. R. Bernardi, and P.P. Pandolfi Role of PML and the PML-nuclear body in the control of programmed cell death Oncogene 22 2003 9048 9057
66. K.L. Borden Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies Mol. Cell. Biol. 22 2002 5259 5269
67. G. Dellaire, and D.P. Bazett-Jones PML nuclear bodies: dynamic sensors of DNA damage and cellular stress Bioessays 26 2004 963 977
68. A. Guo, P. Salomoni, J. Luo, A. Shih, S. Zhong, W. Gu, and P. Paolo Pandolfi The function of PML in p53-dependent apoptosis Nat. Cell Biol. 2 2000 730 736
69. Z.G. Wang, D. Ruggero, S. Ronchetti, S. Zhong, M. Gaboli, R. Rivi, and P.P. Pandolfi PML is essential for multiple apoptotic pathways Nat. Genet. 20 1998 266 272
70. E. de Stanchina, E. Querido, M. Narita, R.V. Davuluri, P.P. Pandolfi, G. Ferbeyre, and S.W. Lowe PML is a direct p53 target that modulates p53 effector functions Mol. Cell 13 2004 523 535
71. F.M. Boisvert, M.J. Kruhlak, A.K. Box, M.J. Hendzel, and D.P. Bazett-Jones The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body J. Cell Biol. 152 2001 1099 1106
72. X. Wei, Z.K. Yu, A. Ramalingam, S.R. Grossman, J.H. Yu, D.B. Bloch, and C.G. Maki Physical and functional interactions between PML and MDM2 J. Biol. Chem. 278 2003 29288 29297
73. H. Zhu, L. Wu, and C.G. Maki MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53 J. Biol. Chem. 278 2003 49286 49292
74. I. Louria-Hayon, T. Grossman, R.V. Sionov, O. Alsheich, P.P. Pandolfi, and Y. Haupt The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation J. Biol. Chem. 278 2003 33134 33141
75. T. Unger, T. Juven-Gershon, E. Moallem, M. Berger, R. Vogt Sionov, G. Lozano, M. Oren, and Y. Haupt Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 EMBO J. 18 1999 1805 1814
76. G. D'Orazi, B. Cecchinelli, T. Bruno, I. Manni, Y. Higashimoto, S. Saito, M. Gostissa, S. Coen, A. Marchetti, G. Del Sal, G. Piaggio, M. Fanciulli, E. Appella, and S. Soddu Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis Nat. Cell Biol. 4 2002 11 19
77. T.G. Hofmann, A. Moller, H. Sirma, H. Zentgraf, Y. Taya, W. Droge, H. Will, and M.L. Schmitz Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 Nat. Cell Biol. 4 2002 1 10
78. A. Moller, H. Sirma, T.G. Hofmann, S. Rueffer, E. Klimczak, W. Droge, H. Will, and M.L. Schmitz PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains Cancer Res. 63 2003 4310 4314
79. P. Haluska Jr., A. Saleem, Z. Rasheed, F. Ahmed, E.W. Su, L.F. Liu, and E.H. Rubin Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein Nucleic Acids Res. 27 1999 2538 2544
80. R. Zhou, H. Wen, and S.Z. Ao Identification of a novel gene encoding a p53-associated protein Gene 235 1999 93 101
81. Z.A. Rasheed, A. Saleem, Y. Ravee, P.P. Pandolfi, and E.H. Rubin The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies Exp. Cell Res. 277 2002 152 160
82. R. Rajendra, D. Malegaonkar, P. Pungaliya, H. Marshall, Z. Rasheed, J. Brownell, L.F. Liu, S. Lutzker, A. Saleem, and E.H. Rubin Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 J. Biol. Chem. 279 2004 36440 36444
83. K. Iwabuchi, P.L. Bartel, B. Li, R. Marraccino, and S. Fields Two cellular proteins that bind to wild-type but not mutant p53 Proc. Natl. Acad. Sci. USA 91 1994 6098 6102
84. K. Iwabuchi, B. Li, H.F. Massa, B.J. Trask, T. Date, and S. Fields Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2 J. Biol. Chem. 273 1998 26061 26068
85. Y. Samuels-Lev, D.J. O'Connor, D. Bergamaschi, G. Trigiante, J.K. Hsieh, S. Zhong, I. Campargue, L. Naumovski, T. Crook, and X. Lu ASPP proteins specifically stimulate the apoptotic function of p53 Mol. Cell 8 2001 781 794
86. N. Takahashi, S. Kobayashi, X. Jiang, K. Kitagori, K. Imai, Y. Hibi, and T. Okamoto Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing Biochem. Biophys. Res. Commun. 315 2004 434 438
87. L. Naumovski, and M.L. Cleary The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M Mol. Cell. Biol. 16 1996 3884 3892
88. J.P. Yang, M. Hori, N. Takahashi, T. Kawabe, H. Kato, and T. Okamoto NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2 Oncogene 18 1999 5177 5186
89. C.D. Lopez, Y. Ao, L.H. Rohde, T.D. Perez, D.J. O'Connor, X. Lu, J.M. Ford, and L. Naumovski Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53 Mol. Cell. Biol. 20 2000 8018 8025
90. D. Bergamaschi, Y. Samuels, B. Jin, S. Duraisingham, T. Crook, and X. Lu ASPP1 and ASPP2: common activators of p53 family members Mol. Cell. Biol. 24 2004 1341 1350
91. D. Bergamaschi, Y. Samuels, N.J. O'Neil, G. Trigiante, T. Crook, J.K. Hsieh, D.J. O'Connor, S. Zhong, I. Campargue, M.L. Tomlinson, P.E. Kuwabara, and X. Lu iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human Nat. Genet. 33 2003 162 167
92. I. Rappold, K. Iwabuchi, T. Date, and J. Chen Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways J. Cell Biol. 153 2001 613 620
93. L.B. Schultz, N.H. Chehab, A. Malikzay, and T.D. Halazonetis p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks J. Cell Biol. 151 2000 1381 1390
94. I.M. Ward, K. Minn, K.G. Jorda, and J. Chen Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX J. Biol. Chem. 278 2003 19579 19582
95. B. Wang, S. Matsuoka, P.B. Carpenter, and S.J. Elledge 53BP1, a mediator of the DNA damage checkpoint Science 298 2002 1435 1438
96. P.G. Ard, C. Chatterjee, S. Kunjibettu, L.R. Adside, L.E. Gralinski, and S.B. McMahon Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complex Mol. Cell. Biol. 22 2002 5650 5661