A TPR motif cofactor contributes to p300 activity in the p53 response

Molecular Cell

Volumn 8, Issue 1, 2001, Pages 71-84

  Demonacos, Constantinos ^a   Krstic Demonacos, Marija ^a   La Thangue, Nicholas B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; PROTEIN MDM2; PROTEIN P300; PROTEIN P53; PROTEIN STRAP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IONIZING RADIATION; MOUSE; NONHUMAN; NUCLEOTIDE REPEAT; OSTEOSARCOMA CELL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; STRESS; ULTRAVIOLET RADIATION;

ANIMALIA;

EID: 0034892854     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00277-5     Document Type: Article

References (54)

1. waf1/cip1 and Mdm2 by etoposide: Etoposide inhibits the p53-Mdm2 autoregulatory feedback loop
2. Recruitment of p300/CBP in p53-dependent signal pathways
3. The tetratricopeptide repeat: A structural motif mediating protein-protein interactions
4. Chaperone function of Hsp90-associated proteins
5. Molecular and functional characterisation of E2F-5, a new member of the E2F family
6. Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53
7. Interactions of p60, a mediator of progesterone receptor assembly with heat shock proteins hsp90 and hsp70
8. Crystal structure of a p53 tumour suppressor-DNA complex: Understanding tumorigenic mutations
9. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
10. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor
11. WAF1, a potential mediator of p53 tumor suppression
12. The complexity of p53 modulation: Emerging patterns from divergent signals
13. Mutations in the p53 tumour suppressor gene: Clues to cancer etiology and molecular pathogenesis
14. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
15. Synergistic activation of transcription by CBP and p53
16. Mdm2 promotes the rapid degradation of p53
17. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
18. Cell death induced by topoisomerase-targeted drugs: More questions than answers
19. Ssn6-Tup1 is a general repressor of transcription in yeast
20. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
21. p53: Puzzle and paradigm
22. Regulation of p53 stability by Mdm2
23. Regulation of p53 in response to DNA damage
24. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis
25. Tetratrico peptide repeat interactions: To TPR or not to TPR
26. Stress-inducible, murine protein mST1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases
27. Functional interplay between p53 and E2F through co-activator p300
28. p53, the cellular gatekeeper for growth and division
29. Binding and modulation of p53 by p300/CBP co-activators
30. Several hydrophobic amino acids in the p53 amino-terminal domains are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
31. Apoptotic and growth-promoting activity of E2F modulated by MDM2
32. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
33. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
34. Mdm2: Keeping p53 under control
35. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90
36. DNA damage activates p53 through a phosphorylation-acetylation cascade
37. Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
38. The PCAF acetylase complex as a potential tumor suppressor
39. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
40. The human homologues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage inducible sites
41. The p300/CBP family: Integrating signals with transcription factors and chromatin
42. A novel co-factor for p300 that regulates the p53 response
43. Functional interaction between nucleosome assembly proteins and p300/CBP co-activators
44. Protein phosphatase 5 is a major component of glucocorticoid receptor hsp90 complexes with properties of an FK506-binding immunophilin
45. The tetratricopeptide repeat domain and a C-terminal region control the activity of Ser/Thr protein phosphatase 5
46. The tetratricopeptide repeats of Ssn6 interact with the homeo domain of α2
47. Functional interaction between DP-1 and p53
48. A role for ATR in the DNA damage induced phosphorylation of p53
49. Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex
50. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 co-repressor complex to differentially regulated promoters
51. Mammalian Ras interacts directly with the serine threonine kinase Raf
52. The p53-mdm2 autoregulatory feedback loop
53. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
54. Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor