Pondering the promyelocytic leukemia protein (PML) puzzle: Possible functions for PML nuclear bodies

Molecular and Cellular Biology

Volumn 22, Issue 15, 2002, Pages 5259-5269

  Borden, Katherine L B ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; RETINOIC ACID RECEPTOR ALPHA; TUMOR PROTEIN;

ANIMAL CELL; CELL NUCLEUS INCLUSION BODY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPLICATION; ELECTRON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; SENESCENCE; SHORT SURVEY; TRANSCRIPTION INITIATION;

ANIMALS; CELL DIVISION; CELL NUCLEUS; CELL NUCLEUS STRUCTURES; CYTOPLASM; DNA REPLICATION; GENE EXPRESSION REGULATION; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MACROMOLECULAR SUBSTANCES; NEOPLASM PROTEINS; NUCLEAR PROTEINS; ORGANELLES; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; ZINC FINGERS;

ANIMALIA;

EID: 0036318221     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.15.5259-5269.2002     Document Type: Short Survey

References (107)

1. Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication
2. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein
3. Identification of a novel nuclear domain
4. Accumulation and intranuclear distribution of unintegrated human immunodeficiency virus type 1 DNA
5. Exploring (novel) gene expression during retinoid-induced maturation and cell death of acute promyelocytic leukemia
6. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
7. Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA
8. RING domains: Master builders of molecular scaffolds?
9. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML
10. Two RING finger proteins, the oncoprotein PML and the arenavirus Z protein, colocalize with the nuclear fraction of the ribosomal P proteins
11. An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm
12. The promyelocytic leukemia protein PML has a pro-apoptotic activity mediated through its RING domain
13. In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML
14. The lymphocytic choriomeningitis virus RING protein Z associates with eukaryotic initiation factor 4E and selectively represses translation in a RING-dependent manner
15. Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase
16. Evidence for proteasome involvement in polyglutamine disease: Localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro
17. Cell-cycle regulation of DNA damage-induced expression of the suppressor gene PML
18. Induction of the PML protein by interferons in normal and APL cells
19. PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
20. Exclusion of Int-6 from PML nuclear bodies by binding to the HTLVA-I Tax oncoprotein
21. Role of the promyelocytic leukemia protein PML in the interferon sensitivity of lymphocytic choriomeningitis virus
22. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling
23. SUMO-1 modification of the acute promyelocytic leukaemia protein PML: Implications for nuclear localization
24. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
25. DNA viruses and viral proteins that interact with PML nuclear bodies
26. Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms
27. PML is induced by oncogenic ras and promotes premature senescence
28. Cell death induction by the acute promyelocytic leukemiaspecific PML/RARalpha fusion protein
29. Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: Immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia
30. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells
31. The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3′ splice site
32. Cajal bodies: The first 100 years
33. Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: Comparison with the Werner's syndrome helicase
34. Molecular cloning of a new interferon-induced PML nuclear body-associated protein
35. PML-containing nuclear bodies: Their spatial distribution in relation to other nuclear components
36. Characterization of the PML/RARα rearrangement associated with t(15;17) acute promyelocytic leukaemia
37. 2/M phase of the cell cycle
38. Effect of PML and PML-RAR on the transactivation properties and subcellular distribution of steroid hormone receptors
39. Immunohistochemical expression and pathogenesis of BLM in the human brain and visceral organs
40. Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies
41. Coupled transcription and translation within nuclei of mammalian cells
42. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
43. PML protein isoforms and the RBCC/TRIM motif
44. Combinatorial roles of the nuclear receptor corepressor in transcription and development
45. Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): Structural similarities with a new family of oncoproteins
46. Construction of macromolecular assemblages in eukaryotic processes and their role in human disease: Linking RINGs together
47. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E
48. Self-assembly properties of a model RING domain
49. Role of PML and PML-RARα in Mad-mediated transcriptional repression
50. The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA
51. 3-induced PML or PML/retinoic acid receptor alpha degradation
52. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body
53. Initiation factor eIF-4E of Saccharomyces cerevisiae. Distribution within the cell, binding to mRNA, and consequences of its overproduction
54. The acute promyelocytic leukaemia-associated PML gene is induced by interferon
55. Ras mediates translation initiation factor 4E-induced malignant transformation
56. 1 cell cycle arrest and apoptosis
57. Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML
58. A fraction of the mRNA 5′ cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus
59. Review: Properties and assembly mechanisms of ND10, PML bodies, or PODs
60. Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress
61. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
62. SUMO - Nonclassical ubiquitin
63. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
64. p53 binds selectively to the 5′-untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor β- and p53-mediated translational inhibition of cdk4
65. Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus
66. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold)
67. SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements
68. The XHex homeobox gene is expressed during development of the vascular endothelium: Overexpression leads to an increase in vascular endothelial cell number
69. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro
70. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
71. PML induces a novel caspase-independent death process
72. Role and fate of PML nuclear bodies in response to interferon and viral infections
73. PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator
74. PML and COP1 - Two proteins with much in common
75. The acute promyelocytic leukemia-specific PML/RARα fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells
76. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels
77. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E
78. Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: Nomenclature of cells and repertory of their known genetic alterations and phenotypes
79. Identification of the Ga14 suppressor Sug1 as a subunit of the yeast 26S proteasome
80. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: Immunocytochemical evidence for differential distribution during changes in functional states
81. Nuclear domains enriched in RNA 3′-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner
82. The PML nuclear bodies: Actors or extras?
83. PML bodies associate specifically with the MHC gene cluster in interphase nuclei
84. Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase
85. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
86. The mRNA 5′ cap-binding protein eIF4E and control of cell growth
87. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element
88. The emerging roles for nuclear translation factors
89. A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies
90. PML nuclear bodies are general targets for inflammation and cell proliferation
91. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: A RING may link hematopoiesis and growth control
92. Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E mRNA transport of cyclin D1 in a PML-dependent manner
93. Visualization of gene activity in living cells
94. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: Interference with early steps of viral replication
95. The distribution and expression of the Bloom's syndrome gene product in normal and neoplastic human cells
96. Transcriptional repression by the promyelocytic leukemia protein, PML
97. Nuclear distribution of prothymosin alpha and parathymosin: Evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication
98. Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1
99. Functional interaction of p53 and BLM DNA helicase in apoptosis
100. Role of PML in cell growth and the retinoic acid pathway
101. PML is essential for multiple apoptotic pathways
102. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
103. Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm
104. Nuclear structure in normal and Bloom syndrome cells
105. The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability
106. Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies
107. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body