Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

Journal of Molecular Biology

Volumn 348, Issue 5, 2005, Pages 1199-1210

  Chen, Qiang ^a   Liang, Yuhe ^a   Su, Xiaodong ^a   Gu, Xiaocheng ^a   Zheng, Xiaofeng ^a   Luo, Ming ^a,b  

^a PEKING UNIVERSITY   (China)

^b University of Alabama at Birmingham   (United States)

Author keywords

Crystal structure; Feedback inhibition; HGPRT; IMP; Thermostability

Indexed keywords

5' PHOSPHATE; ALPHA DEXTRO PHOSPHORIBOSYL 1 PYROPHOSPHATE; APOENZYME; ASPARTIC ACID; ENZYME; GLUTAMIC ACID; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINE PHOSPHATE; MAGNESIUM ION; PHOSPHATE; PHOSPHORIBOSYLTRANSFERASE; PYROPHOSPHORIC ACID DERIVATIVE; SERINE; TETRAMER; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; INHIBITION KINETICS; MEASUREMENT; MOLECULE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ANALYSIS; THERMOANAEROBACTER TENGCONGENSIS; THERMOPHILIC BACTERIUM; THERMOSTABILITY;

EID: 18044392590     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.02.064     Document Type: Article

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