Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase

Journal of Molecular Biology

Volumn 282, Issue 4, 1998, Pages 875-889

  Vos, Siska ^a   Parry, Ronald J ^b   Burns, Mark R ^b   De Jersey, John ^a   Martin, Jennifer L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RICE UNIVERSITY   (United States)

Author keywords

Enzyme ligand complexes; Phosphoribosyltransferases; Protein structure; Purine salvage; X ray crystallography

Indexed keywords

GUANINE; MAGNESIUM; PHOSPHORIBOSYLTRANSFERASE; PROTON; SULFATE; XANTHINE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0032475913     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2051     Document Type: Article

References (50)

1. Aldritt S.M., Wang C.C. Purification and characterisation of guanine phosphoribosyltransferase from Giardia lamblia. J. Biol. Chem. 261:1986;8528-8533
2. Allen T.E., Ullman B. Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma brucei. Nucl. Acids Res. 21:1993;5431-5438
3. Allen T.E., Ullman B. Molecular characterisation and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi. Mol. Biochem. Parasitol. 65:1994;233-245
4. Allen T., Henschel E.V., Coons T., Cross L., Conley J., Ullman B. Purification and characterisation of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani. Mol. Biochem. Parasitol. 33:1989;273-282
5. Bacon D.J., Anderson W.F. A fast algorithm for rendering space filling molecular pictures. J. Mol. Graph. 6:1988;219-222
6. Beck J.T., Wang C.C. The hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus has unique properties. Mol. Biochem. Parasitol. 60:1993;187-194
7. Bhat T.N., Cohen G.H. OMITMAP an electron density map suitable for the examination of errors in a macromolecular model. J. Appl. Crystallog. 17:1984;244-248
8. Brünger A.T. X-PLOR Version 3.1. A System for X-ray Crystallography and NMR. 1992;Yale University Press, New Haven, CT
9. Brünger A.T. The free R value a novel statistical quantity for assessing the accuracy of crystal structures. Nature. 355:1992;472-475
10. Chen S., Tomchick D.R., Wolle D., Hu P., Smith J.L., Switzer R.L., Zalkin H. Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides. Biochemistry. 36:1997;10718-10726
11. Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 269:1995;496-512
12. Deo S.S., Tseng W.C., Saini R., Coles R.S., Athwal R.S. Purification and characterisation of Escherichia coli xanthine-guanine phosphoribosyltransferase produced by plasmid pSV2gpt. Biochim. Biophys. Acta. 839:1985;233-239
13. Eads J.C., Scapin G., Xu Y., Grubmeyer C., Sacchettini J.C. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. Cell. 78:1994;325-334
14. Eads J.C., Ozturk D., Wexler T.B., Grubmeyer C., Sacchettini J.C. A new function for a common fold the crystal structure of quinolinic acid phosphoribosyltransferase. Structure. 5:1997;47-58
15. Evans S.V. SETOR hardware lighted three-dimensional solid model representations of macromolecules. J. Mol. Graph. 11:1993;134-138
16. Giacomello A., Salerno C. Human hypoxanthine-guanine phosphoribosyltransferase. Steady state kinetics of the forward and reverse reactions. J. Biol. Chem. 253:1978;6038-6044
17. 3H substrate kinetic isotope effects for some phosphoribosyltransferases. J. Biol. Chem. 253:1978;2963-2971
18. Henriksen A., Aghajari N., Jensen K.F., Gajhede M. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase. Biochemistry. 35:1996;3803-3809
19. Hershey H.V., Taylor M.W. Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes. Gene. 43:1986;287-293
20. Hooft R.W.W., Vriend G., Sander C., Abola E.E. Errors in protein structures. Nature. 381:1996;272
21. Hove-Jensen B., Harlow K.W., King C.J., Switzer R.L. Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene. J. Biol. Chem. 261:1986;6765-6771
22. Hutchinson E.G., Thornton J.M. PROMOTIF- a program to identify and analyse structural motifs in proteins. Protein Sci. 5:1996;212-220
23. Jardim A., Ullman B. The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity. J. Biol. Chem. 272:1997;8967-8973
24. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallog. sect. A. 47:1991;110-119
25. Kim J.H., Krahn J.M., Tomchick D.R., Smith J.L., Zalkin H. Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site. J. Biol. Chem. 271:1996;15549-15557
26. Krahn J.M., Kim J.H., Burns M.R., Parry R.J., Zalkin H., Smith J.L. Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site. Biochemistry. 36:1997;11061-11068
27. Kraulis P.J. MOLSCRIPT a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallog. 24:1991;946-950
28. Laskowski R.A., MacArthur M.W., Moss D.S., Thornton J.M. PROCHECK a program to check the stereochemical quality of protein structures. J. Appl. Crystallog. 26:1993;283-291
29. Luzzati V. Traitement statistique des erreurs dans la determination des structures cristallines. Acta Crystallog. 5:1952;802-810
30. Matthews B.W. Solvent content of protein crystals. J. Mol. Biol. 33:1968;491-497
31. Merritt E.A., Murphy M.E.P. Raster3D version 2.0. A program for photorealistic molecular graphics. Acta Crystallog. sect. D. 50:1994;869-873
32. Musick W.D.L. Structural features of the phosphoribosyltransferases and their relationship to the human deficiency disorders of purine and pyrimidine metabolism. CRC Crit. Rev. Biochem. 11:1981;1-34
33. Nygaard P. Utilization of preformed purine bases and nucleosides. Munch-Petersen A. Metabolism of Nucleotides, Nucleosides and Nucleobases in Microorganisms. 1983;41-54 Academic Press, London
34. Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Carter C.W. Jr, Sweet R.M. Methods in Enzymology. vol. 276:1997;307-326 Academic Press, New York
35. Ozturk D.H., Dorfman R.H., Scapin G., Sacchettini J.C., Grubmeyer C. Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase. Biochemistry. 34:1995;10755-10763
36. Ozturk D.H., Dorfman R.H., Scapin G., Sacchettini J.C., Grubmeyer C. Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase protein complementation reveals shared active sites. Biochemistry. 34:1995;10764-10770
37. Parry R.J., Burns M.R., Jiralerspong S., Alemany L. Synthesis of (+)-(1S)-1-pyrophosphoryl-(2R,3R)-2,3-dihydroxy-(4S)-4-(phosphoryloxymethyl) cyclopentane, a stable, optically-active carbocyclic analog of 5-phosphoribosyl-1-pyro phosphate (PRPP). Tetrahedron. 53:1997;7077-7088
38. Queen S.A., van der Jagt D., Reyes P. Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum. Mol. Biochem. Parasitol. 30:1988;123-134
39. Ramachandran G.N., Ramakrishnan C., Sasisekharan V. Stereochemistry of polypeptide chain conformations. J. Mol. Biol. 7:1963;95-99
40. Scapin G., Grubmeyer C., Sacchettini J.C. Crystal structure of orotate phosphoribosyltransferase. Biochemistry. 33:1994;1287-1294
41. Scapin G., Ozturk D.H., Grubmeyer C., Sacchettini J.C. The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and α-D-5-phosphoribosyl-1-pyrophosphate. Biochemistry. 34:1995;10744-10754
42. Schumacher M.A., Carter D., Roos D.S., Ullman B., Brennan R.G. Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. Nat. Struct. Biol. 3:1996;881-887
43. Smith J.L., Zaluzec E.J., Wery J.-P., Niu L., Switzer R.L., Zalkin H., Satow Y. Structure of the allosteric regulatory enzyme of purine biosynthesis. Science. 264:1994;1427-1433
44. Somoza J.R., Chin M.S., Focia P.J., Wang C.C., Fletterick R.J. Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry. 35:1996;7032-7040
45. Tao W., Grubmeyer C., Blanchard J.S. Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase. Biochemistry. 35:1996;14-21
46. Vos S., de Jersey J., Martin J.L. Crystallization and preliminary X-ray crystallographic studies of Escherichia coli xanthine phosphoribosyltransferase. J. Struct. Biol. 116:1996;330-334
47. Vos S., de Jersey J., Martin J.L. Crystal structure of Escherichia coli xanthine phosphoribosyltransferase. Biochemistry. 36:1997;4125-4134
48. Wang C.C., Simashkevich P.M. Purine metabolism in the protozoan parasite Eimeria tenella. Proc. Natl Acad. Sci. USA. 78:1981;6618-6622
49. Wriggers W., Schulten K. Protein domain movements detection of rigid domains and visualization of hinges in comparisons of atomic coordinates. Proteins: Struct. Funct. Genet. 29:1997;1-14
50. Xu Y., Grubmeyer C. Catalysis in human hypoxanthine-guanine phosphoribosyltransferase Asp-137 acts as a general acid/base. Biochemistry. 37:1998;4114-4124