A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 10, 2004, Pages 2671-2677

  Sun, Hongmao ^a   Greeley, David N ^a   Chu, Xin Jie ^a   Cheung, Adrian ^a   Danho, Waleed ^a   Swistok, Joseph ^a   Wang, Yao ^a   Zhao, Chunlin ^a   Chen, Li ^a   Fry, David C ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Cyclic peptides; MC4R; NMR; Pharmacophore model

Indexed keywords

LIGAND; MELANOCORTIN 4 RECEPTOR; PEPTIDE DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CYCLIZATION; DERIVATIZATION; DRUG ACTIVITY; DRUG DESIGN; DRUG FORMULATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; PREDICTION; REDUCTION KINETICS; STRUCTURE ACTIVITY RELATION;

HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 4; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144353624     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.017     Document Type: Article

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