Reviewing the mechanism of peripheral tolerance in clinical transplantation

Contributions to Nephrology

Volumn 146, Issue , 2005, Pages 132-142

  Suciu Foca, Nicole ^a   Cortesini, Raffaello ^a  

^a Department of Pathology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUPPRESSOR FACTOR;

ALLOTRANSPLANTATION; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; FEMALE; GENETICS; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; MALE; METHODOLOGY; MOUSE; PHYSIOLOGY; PROSPECTIVE STUDY; REVIEW; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION TOLERANCE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNE TOLERANCE; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; MALE; MICE; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SUPPRESSOR FACTORS, IMMUNOLOGIC; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 16544385544     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (63)

1. Hoffmann MW, Heath WR, Ruschmeyer D, Miller JF: Deletion of high-avidity T cells by thymic epithelium. Proc Natl Acad Sci USA 1995;92:9851-9855.
2. Janssen O, Sanzenbacher R, Kabelitz D: Regulation of activation-induced cell death of mature T-lymphocyte populations. Cell Tissue Res 2000;301:85-99.
3. Nguyen T, Russell J: The regulation of FasL expression during activation-induced cell death (AICD). Immunology 2001;103:426-434.
4. Conroy LA, Alexander DR: The role of intracellular signalling pathways regulating thymocyte and leukemic T cell apoptosis. Leukemia 1996;10:1422-1435.
5. Oberg HH, Lengl-Janssen B, Kabelitz D, Janssen O: Activation-induced T cell death: Resistance or susceptibility correlate with cell surface fas ligand expression and T helper phenotype. Cell Immunol 1997;181:93-100.
6. Oberg HH, Sanzenbacher R, Lengl-Janssen B, Dobmeyer T, Flindt S, Janssen O, Kabelitz D: Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression. J Immunol 1997;159:5742-5749.
7. Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA: Molecular basis of T cell inactivation by CTLA-4. Science 1998;282:2263-2266.
8. Wells AD, Walsh MC, Bluestone JA, Turka LA: Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 2001;108:895-903.
9. Chambers CA, Allison JP: Costimulatory regulation of T cell function. Curr Opin Cell Biol 1999;11:203-210.
10. Suciu-Foca N, Manavalan JS, Cortesini R: Generation and function of antigen-specific suppressor and regulatory T cells. Transpl Immunol 2003;11:235-244.
11. Sutmuller RP, Offringa R, Melief CJ: Revival of the regulatory T cell: New targets for drug development. Drug Discov Today 2004;9:310-316.
12. Nagler-Anderson C, Bhan AK, Podolsky DK, Terhorst C: Control freaks: Immune regulatory cells. Nat Immunol 2004;5:119-122.
13. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-1164.
14. Shevach EM, McHugh RS, Piccirillo CA, Thornton AM: Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev 2001;182:58-67.
15. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001;182:18-32.
16. Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S: Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999;162:5317-5326.
17. Shevach EM: Regulatory T cells in autoimmmunity*. Annu Rev Immunol 2000;18:423-449.
18. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061.
19. Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S: Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998;10:1969-1980.
20. Thornton AM, Donovan EE, Piccirillo CA, Shevach EM: Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004;172: 6519-6523.
21. Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA, Naji A, Caton AJ: Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-306.
22. Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF: Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003;112:1437-1443.
23. Read S, Malmstrom V, Powrie F: Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
24. Kingsley CI, Karim M, Bushell AR, Wood KJ: CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and LL-10-dependent immunoregulation of alloresponses. J Immunol 2002;168:1080-1086.
25. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S: Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-142.
26. McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC: CD4(+)CD25(+) Immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002;16:311-323.
27. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742.
28. Bacchetta R, Bigler M, Touraine JL, Parkman R, Tovo PA, Abrams J, de Waal Malefyt R, de Vries JE, Roncarolo MG: High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994;179:493-502.
29. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F: An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999;190:995-1004.
30. Kitani A, Chua K, Nakamura K, Strober W: Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells. J Immunol 2000;165:691-702.
31. Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL: A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996;183:2669-2674.
32. Levings MK, Sangregorio R, Galbiati F, Squadrone S, de Waal Malefyt R, Roncarolo MG: IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001;166:5530-5539.
33. Dieckmann D, Bruett CH, Ploettner H, Lutz MB, Schuler G: Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med 2002;196:247-253.
34. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH: Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002;196:255-260.
35. Liu Z, Tugulea S, Cortesini R, Suciu-Foca N: Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells. Int Immunol 1998;10:775-783.
36. Ciubotariu R, Colovai AI, Pennesi G, Liu Z, Smith D, Berlocco P, Cortesini R, Suciu-Foca N: Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28-regulatory T cells. J Immunol 1998;161:5193-5202.
37. Jiang S, Tugulea S, Pennesi G, Liu Z, Mulder A, Lederman S, Harris P, Cortesini R, Suciu-Foca N: Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro. Hum Immunol 1998;59:690-699.
38. Colovai AI, Liu Z, Ciubotariu R, Lederman S, Cortesini R, Suciu-Foca N: Induction of xenoreactive CD4+ T-cell anergy by suppressor CD8+CD28- T cells. Transplantation 2000;69:1304-1310.
39. Liu Z, Tugulea S, Cortesini R, Lederman S, Suciu-Foca N: Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells. Hum Immunol 1999;60:568-574.
40. Li J, Liu Z, Jiang S, Cortesini R, Lederman S, Suciu-Foca N: T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC. J Immunol 1999;163:6386-6392.
41. Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N: Tolerization of dendritic cells by T(S) cells: The crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002;3:237-243.
42. Suciu-Foca Cortesini N, Piazza F, Ho E, Ciubotariu R, LeMaoult J, Dalla-Favera R, Cortesini R: Distinct mRNA microarray profiles of tolerogenic dendritic cells. Hum Immunol 2001;62:1065-1072.
43. Cortesini R, LeMaoult J, Ciubotariu R, Cortesini NS: CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity. Immunol Rev 2001;182:201-206.
44. Colovai AI, Mirza M, Vlad G, Wang S, Ho E, Cortesini R, Suciu-Foca N: Regulatory CD8+CD28- T cells in heart transplant recipients. Hum Immunol 2003;64:31-37.
45. Ciubotariu R, Vasilescu R, Ho E, Cinti P, Cancedda C, Poli L, Late M, Liu Z, Berloco P, Cortesini R, Suciu-Foca Cortesini N: Detection of T suppressor cells in patients with organ allografts. Hum Immunol 2001;62:15-20.
46. Cortesini R, Renna-Molajoni E, Cinti P, Pretagostini R, Ho E, Rossi P, Suciu-Foca Cortesini N: Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells. Hum Immunol 2002;63:1010-1018.
47. Manavalan JS, Rossi PC, Vlad G, Piazza F, Yarilina A, Cortesini R, Mancini D, Suciu-Foca N: High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 2003;11:245-258.
48. Manavalan JS, Kim-Schulze S, Scotto L, Naiyer AJ, Vlad G, Colombo P, Marboe C, Mancini D, Cortesini R, Suciu-Foca N: Alloantigen specific CD8+ CD28- FOXP3+ T suppressors cells induce tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol DOI:10.1159/000063858.
49. Stephens LA, Mason D: CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25-subpopulations. J Immunol 2000;165:3105-3110.
50. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S: Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-142.
51. Fu S, Yopp AC, Mao X, Chen D, Zhang N, Mao M, Ding Y, Bromberg JS: CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 2004;4:65-78.
52. Takeda I, Ine S, Killeen N, Ndhlovu LC, Murata K, Satomi S, Sugamura K, Ishii N: Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol 2004;172:3580-3589.
53. Choi BK, Bae JS, Choi EM, Kang WJ, Sakaguchi S, Vinay DS, Kwon BS: 4-1 BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells. J Leukoc Biol 2004;75:785-791.
54. Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P: Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med 2002;196:379-387.
55. Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V Brunner M, Scheffold A, Hamann A: Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci USA 2002;99:13031-13036.
56. Suciu-Foca N, Manavalan JS, Scotto L, Kim-Schulze S, Galluzzo S, Naiyer AJ, Fan J, Vlad G, Cortesini R: Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: Review. Int J Immunopharmacol; in press.
57. Colonna M, Nakajima H, Navarro F, Lopez-Botet M: A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J Leukoc Biol 1999;66:375-381.
58. Colonna M, Nakajima H, Cella M: A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin Immunol 2000;12:121-127.
59. Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol 1998;160:3096-3100.
60. Ravetch JV, Lanier LL: Immune inhibitory receptors. Science 2000;290:84-89.
61. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M: A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med 1997;185:1743-1751.
62. Waldmann H, Cobbold S: Regulating the immune response to transplants. A role for CD4+ regulatory cells? Immunity 2001;14:399-406.
63. Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ: Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest 2003;112:1037-1048.