A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing

Journal of Experimental Medicine

Volumn 185, Issue 10, 1997, Pages 1743-1752

  Cella, Marina ^a   Döhring, Christian ^a   Samaridis, Jacqueline ^a   Dessing, Mark ^a   Brockhaus, Manfred ^b   Lanzavecchia, Antonio ^a   Colonna, Marco ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; IMMUNOGLOBULIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; B-LYMPHOCYTES; BASE SEQUENCE; CALCIUM; CELL LINE; CLONING, MOLECULAR; DENDRITIC CELLS; DNA PRIMERS; HUMANS; IMMUNOGLOBULIN G; JURKAT CELLS; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; MONOCYTES; PHOSPHOTYROSINE; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES; TRANSFECTION;

EID: 1842335724     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.10.1743     Document Type: Article

References (63)

1. Cambier, J.C., C.M. Pleiman, and M.R. Clark. 1994. Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rep. Immunol. 12:457-486.
2. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
3. Letourneur, F., and R.D. Klausner. 1991. T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor C family proteins. Proc. Natl. Acad. Sci. USA. 88:8905-8909.
4. Letourneur, O., I.C. Kennedy, A.T. Brini, J.R. Ortaldo, J.J. O'Shea, and J.P. Kinet. 1991. Characterization of the family of dimers associated with Fc receptors (Fc∈ RI and Fcγ RIII). J. Immunol. 147:2652-2656.
5. Bonnerot, C., S. Amigorena, D. Choquet, R. Pavlovich, V. Choukroun, and W.H. Fridman. 1992. Role of associated γ-chain in tyrosine kinase activation via niurine FcγRIII. EMBO (Eur. Mol. Biol. Organ.) J. 11:2747-2757.
6. Daeron, M., O. Malbec, C. Bonnerot, S. Latour, D.M. Segal, and W.H. Fridman. 1994. Tyrosine-containing activation motif-dependent phagocytosis in mast cells. J. Immunol 152:783-792.
7. Amigorena, S., C. Bonnerot, J.R. Drake, D. Choquet, W. Hunziker, J.G. Guillet, P. Webster, C. Sautes, I. Mellman, and W.H. Fridman. 1992. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science (Wash. DC). 256:1808-1812.
8. Muta, T., T. Kurosaki, Z. Misulovin, M. Sanchez, M.C. Nussenzweig, and J.V. Ravetch. 1994. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature (Lond.). 368:70-73.
9. Daeron, M., S. Latour, O. Malbec, E. Espinosa, P. Pina, S. Pasmans, and W.H. Fridman. 1995. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity. 3:635-646.
10. Doody, G.M., L.B. Justement, C.C. Delibrias, R.J. Matthews, J. Lin, M.L. Thomas, and D.T. Fearon. 1995. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science (Wash. DC). 269:242-244.
11. Yokoyama, W.M., and W.E. Seaman. 1993. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11:613-635.
12. Lanier, L.L., and J.H. Phillips. 1996. Inhibitory MHC class I receptor on NK cells and T cells. Immunol. Today. 17:86-91.
13. Lazetic, S., C. Chang, J.P. Houchins, L.L. Lanier, and J.H. Phillips. 1996. Human natural killer cell receptors involved in MHC class I recognition are disulfide linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 157:4741-4745.
14. Katz, H.R., E. Vivier, M.C. Castells, M.J. McCormick, J.M. Chambers, and F.K. Austen. 1996. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc. Natl. Acad. Sci. USA. 93:10809-10814.
15. Wang, L.L., I.K. Mehta, P.A. LeBlanc, and W.M. Yokoyama. 1997. Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors. J. Immunol. 158:13-17.
16. Rojo, S., D.N. Burshtyn, E.O. Long, and N. Wagtmann. 1997. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J. Immunol. 158:9-12.
17. Thomas, M.L. 1995. Of ITAMs and ITIMs: turning on and off the B cell antigen receptor. J. Exp. Med. 181:1953-1956.
18. D'Ambrosio, D., K.L. Hippen, S.A. Minskoff, I. Mellman, G. Pani, K.A. Siminovitch, and J.C. Cambier. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1. Science (Wash. DC). 268:293-297.
19. Burshtyn, D.N., A.M. Scharenberg, N. Wagtmann, S. Rajagopalan, K. Berrada, T. Yi, J.P. Kinet, and E.O. Long. 1996. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity. 4:77-85.
20. Campbell, K.S., M. Dessing, M. Lopez Botet, M. Cella, and M. Colonna. 1996. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. J. Exp. Med. 184:93-100.
21. Olcese, L., P. Lang, F. Vely, A. Cambiaggi, D. Marguet, M. Blery, K.L. Hippen, R. Biassoni, A. Moretta, L. Moretta, J.C. Cambier, and E. Vivier. 1996. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol. 156:4531-4534.
22. Fry, A.M., L.L. Lanier, and A. Weiss. 1996. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J. Exp. Med. 184:295-300.
23. Binstadt, B.A., K.M. Brumbaugh, C.J. Dick, A.M. Scharenberg, B.L. Williams, M. Colonna, L.L. Lanier, J.-P. Kinet, R.T. Abraham, and P.J. Leibson. 1996. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 5:629-638.
24. Ono, M., S. Bolland, P. Tempst, and J.V. Ravetch. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature (Lond.). 383:263-266.
25. Samaridis, J., and M. Colonna. 1997. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27:660-665.
26. Zhang, G., J.R. Young, C.A. Tregaskes, P. Sopp, and C.J. Howard. 1995. Identification of a novel class of mammalian Fcγ receptor. J. Immunol. 155:1534-1541.
27. Arm, J.P., M.F. Gurish, D.S. Reynolds, H.C. Scott, C.S. Gartner, K.F. Austen, and H.R. Katz. 1991. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J. Biol. Chem. 266:15966-15973.
28. Colonna, M., and J. Samaridis. 1995. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science (Wash. DC). 268:405-408.
29. Wagtmann, N., R. Biassoni, C. Cantoni, S. Verdiani, M.S. Malnati, M. Vitale, C. Bottino, L. Moretta, A. Moretta, and E.O. Long. 1995. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra-and intracellular domains. Immunity. 2:439-449.
30. D'Andrea, A., C. Chang, K. Franz-Bacon, T. McClanahan, J.H. Phillips, and L.L. Lanier. 1995. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306-2310.
31. Maliszewski, C.R., C.J. March, M.A. Schoenborn, S. Gimpel, and L. Shen. 1990. Expression cloning of a human Fc receptor for IgA. J. Exp. Med. 172:1665-1672.
32. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109-1118.
33. Bender, A., M. Sapp, G. Schuler, R.M. Steinman, and N. Bhardwaj. 1996. Improved methods for the generation of dendritic cells from non proliferating progenitors in human blood J. Immunol. Methods. 196:121-135.
34. Romani, N., D. Reider, M. Heuer, S. Ebner, E. Kampgen, B. Eibl, D. Niederwieser, and G. Schuler. 1996. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods. 196:137-151.
35. Frohman, M.A., M.K. Dush, and G.R. Martin. 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc Natl. Acad. Sci. USA. 85:8998-9002.
36. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 8.11.
37. Traunecker, A., F. Oliven, and K. Karjalainen. 1991. Myeloma based expression system for production of large mammalian proteins. Trends Biotechnol. 9:109-113.
38. Dohring, C., and M. Colonna. 1996. Human natural killer cell inhibitory receptors bind to HLA class I molecules. Eur. J. Immunol. 26:365-369.
39. Reid, P.A., and C. Watts. 1990. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments. Nature (Lond.). 346:655-657.
40. Dohring, C., D. Scheidegger, J. Samaridis, M. Cella, and M. Colonna. 1996. A human killer inhibitory receptor specific for HLA-A. J. Immunol. 156:3098-3101.
41. Valitutti, S., M. Dessing, and A. Lanzavecchia. 1993. Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility. Eur. J. Immunol. 23:790-795.
42. Lanzavecchia, A., S. Abrignani, D. Scheidegger, R. Obrist, B. Dorken, and G. Moldenhauer. 1988. Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets. J. Exp. Med. 167:345-352.
43. Williams, A.F., and N.A. Barclay. 1988. The immunoglobulin superfamily-domains for cell surface recognition. Ann. Rev. Immunol. 6:381-405.
44. Zhou, L.J., and T.F. Tedder. 1995. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154:3821-3835.
45. Zhou, L.J., and T.F. Tedder. 1996. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl. Acad. Sci. USA. 93:2588-2592.
46. O'Doherty, U., R.M. Steinman, M. Peng, P.U. Cameron, S. Gezelter, I. Kopeloff, W.J. Swiggard, M. Pope, and N. Bhardwaj. 1993. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J. Exp. Med. 178:1067-1076.
47. Altieri, D.C., S.J. Stamnes, and C.G. Gahmberg. 1992. Regulated Ca2+ signalling through leukocyte CD11b/CD18 integrin. Biochem. J. 288:465-473.
48. Crockett-Torabi, E., B. Sulenbarger, C.W. Smith, and J.C. Fantone. 1995. Activation of human neutrophils through L-selectin and Mac-1 molecules. J. Immunol. 154:2291-2302.
49. Cambier, J.C., D.C. Morrison, M.M. Chien, and K.R. Lehmann. 1991. Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia crosslinking. J. Immunol. 146:2075-2082.
50. Cambier, J.C., and K.R. Lehmann. 1989. Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J. Exp. Med. 170:877-886.
51. Charron, D., S. Brick-Ghannam, R. Ramirez, and N. Mooney. 1991. HLA class-II-mediated B-lymphocyte activation: signal transduction and physiologic consequences. Res. Immunol. 142:467-474.
52. Cassatella, M.A., I. Anegon, M.C. Cuturi, P. Griskey, G. Trinchieri, and B. Perussia. 1989. FcγR(CD16) interaction with ligand induces Ca2+ mobilization and phosphoinositide turnover in human natural killer cells. Role of Ca2+ in FcγR (CD16)-induced transcription and expression of lymphokine genes. J. Exp. Med. 169:549-567.
53. Ravetch, J.V., and J.P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9:457-492.
54. Trowbridge, I.S., J.F. Collawn, and C.R. Hopkins. 1993. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell. Biol. 9:129-161.
55. Letourneur, F., and R.D. Klausner. 1992. A novel di-leucine motif and a tyrosine-based motif independendy mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69:1143-1157.
56. Sandoval, I.V., and O. Bakke. 1994. Targeting of membrane proteins to endosomes and lysosomes. Trends Cell Biol. 4: 292-297.
57. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
58. Jiang, W., W.J. Swiggard, C. Heufler, M. Peng, A. Mirza, R.M. Steinman, and M.C. Nussenzweig. 1995. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature (Lond.). 375:151-155.
59. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:389-400.
60. Bieber, T., H. de la Salle, A. Wollenberg, J. Hakimi, R. Chizzonite, J. Ring, D. Hanau, and C. de la Salle. 1992. Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc∈RI). J. Exp. Med. 175:1285-1290.
61. Porcelli, S.A. 1995. The CD1 family: a third lineage of antigen-presenting molecules. Adv. Immunol. 59:1-98.
62. Hashimoto, K., M. Hirai, and Y. Kurosawa. 1995. A gene outside the human MHC related to classical HLA class I genes Science (Wash. DC). 269:693-695.
63. Bahram, S., M. Bresnahan, D.E. Geraghty, and T. Spies. 1994. A second lineage of mammalian major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. USA. 91: 6259-6263.