Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: Highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid

Biochemical Pharmacology

Volumn 67, Issue 8, 2004, Pages 1445-1457

  Schwarz, Dieter ^a   Kisselev, Pyotr ^b   Ericksen, Spencer S ^c   Szklarz, Grazyna D ^c   Chernogolov, Alexey ^a,e,f   Honeck, Horst ^d   Schunck, Wolf Hagen ^d   Roots, Ivar ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e BELARUSIAN STATE UNIVERSITY   (Belarus)

^f LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

AA; Arachidonic acid (eicosatetraenoic acid); CYP; CYP1A1; Cytochrome P450; EET; Eicosapentaenoic acid; EPA; Epoxyeicosatrienoic acid; HETE; Human cytochrome P450 1A1; Human NADPH cytochrome P450 reductase; P450 reductase; Sf9; Spodoptera frugiperda insect cells

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; CARBON; CYTOCHROME P450 1A1; EPOXYICOSATRIENOIC ACID; HYDROGEN; ICOSAPENTAENOIC ACID; OXYGENASE; POLYUNSATURATED FATTY ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CHEMICAL BOND; ENZYME PURIFICATION; EPOXIDATION; HUMAN; HYDROXYLATION; INSECT CELL; LEPIDOPTERA; METABOLITE; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; STEREOCHEMISTRY;

EID: 1642372110     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.12.023     Document Type: Article

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