Human cytochrome P-450 metabolism of retinals to retinoic acids

Drug Metabolism and Disposition

Volumn 28, Issue 3, 2000, Pages 292-297

  Zhang, Qing Yu ^a   Dunbar, Deborah ^a   Kaminsky, Laurence ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; ETHOXYRESORUFIN DEETHYLASE; PHENACETIN O DEETHYLASE; RETINAL; RETINOIC ACID;

ARTICLE; DRUG ACTIVITY; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BENZOFLAVONES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RECOMBINANT PROTEINS; RETINALDEHYDE; TRETINOIN;

INSECTA;

EID: 0034090984     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Bhat PV and Samaha H (1999) Kinetic properties of the human liver cytosolic aldehyde dehydrogenase for retinal isomers. Biochem Pharmacol 57:195-197.
2. Blaner WS and Olson JA (1994) Retinol and retinoic acid metabolism, in The RETINOIDS: Biology, Chemistry, and Medicine, 2nd ed., pp 229-255, Raven Press, New York.
3. Crow JA and Ong DE (1985) Cell-specific immunohistochemical localization of a cellular retinol-binding protein (type two) in the small intestine of rat. Proc Natl Acad Sci USA 82:4707-4711.
4. Dew SE, Wardlaw SA and Ong DE (1993) Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes. Cancer Res 53:2965-2969.
5. Ding X, Spink DC, Bhama JK, Sheng JJ, Vaz ADN and Coon MJ (1996) Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes p450. Mol Pharmacol 49:1113-1121.
6. Dinoto R, Lopardo C, Schiavone EM, Ferrara F, Manzo C, Vacca C and Delvecchio L (1996) All-trans retinoic acid (ATRA) and the regulation of adhesion molecules in acute myeloid leukemia. Leuk Lymphoma 21:201-209.
7. Duester G (1996) Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 35:12221-12227.
8. Guengerich FP (1999) Cytochrome P-450 3A4: Regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1-17.
9. Han IS and Choi JH (1996) Highly specific cytochrome P450-like enzymes for all-trans-retinoic acid in T47D human breast cancer cells. J Clin Endocrinol Metab 81:2069-2075.
10. Kaminsky LS, Fraser JM, Seaman M and Dunbar D (1992) Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. Biochem Pharmacol 44:1829-1837.
11. Klyosov AA (1996) Kinetics and specificity of human liver aldehyde dehydrogenase toward aliphatic, aromatic, and fused polycyclic aldehydes. Biochemistry 35:4457-4467.
12. Leo MA, Lasker JM, Raucy JL, Kim C-I. Black M and Lieber CS (1989) Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8. Arch Biochem Biophys 269:305-312.
13. Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J and Kaminsky LS (1999) Characterization of human small intestinal cytochromes P-450. Drug Metab Dispos 27:804-809.
14. Zhang QY, Raner G, Ding X, Dunbar D, Coon MJ and Kaminsky LS (1998) Characterization of the cytochrome P450 CYP2J4: Expression in rat small intestine and role in retinoic acid biotransformation from retinal. Arch Biochem Biophys 353:257-264.