Significance of glycine 478 in the metabolism of N-benzyl-1- aminobenzotriazole to reactive intermediates by cytochrome P450 2B1

Biochemistry

Volumn 36, Issue 39, 1997, Pages 11707-11716

  Kent, Ute M ^a   Hanna, Imad H ^a   Szklarz, Grazyna D ^b   Vaz, Alfin D N ^c   Halpert, James R ^b   Bend, John R ^d   Hollenberg, Paul F ^a,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTRIAZOLE DERIVATIVE; CYTOCHROME P450;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; INFRARED SPECTROMETRY; MALE; MASS SPECTROMETRY; MICROSOME MEMBRANE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; GLYCINE; HEME; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RATS; RATS, INBRED F344; RATS, WISTAR; TRIAZOLES;

ANIMALIA; FELIS CATUS;

EID: 0030865206     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971064y     Document Type: Article

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