Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation

Journal of Biological Chemistry

Volumn 271, Issue 42, 1996, Pages 25864-25872

  He, Kan ^a   He, You Ai ^b   Szklarz, Grazyna D ^b   Halpert, James R ^b   Correia, Maria Almira ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; HEMOPROTEIN; N [5 (2 HYDROXYPROPYL) 5 (1 METHYLBUTYL)BARBITURIC ACID]PROTOPORPHYRIN; PROTOPORPHYRIN; SECOBARBITAL; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; DNA ADDUCT; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME KINETICS; EPOXIDATION; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ALKYLATION; ANIMALS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; EPOXY COMPOUNDS; HEME; MALE; MUTATION; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SECOBARBITAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ATOMIC; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ESCHERICHIA COLI;

EID: 0037905938     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.42.25864     Document Type: Article

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