Epoxidation of benzo[a]pyrene-7, 8-dihydrodiol by human CYP1A1 in reconstituted membranes: Effects of charge and nonbilayer phase propensity of the membrane

European Journal of Biochemistry

Volumn 269, Issue 7, 2002, Pages 1799-1805

  Kisselev, Pyotr ^a   Schwarz, Dieter ^a   Platt, Karl Ludwig ^b   Schunck, Wolf Hagen ^c   Roots, Ivar ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Benzo a pyrene; Benzo a pyrene 7, 8 diol; Epoxidation; Human cytochrome P4501A1; Vesicle reconstitution

Indexed keywords

7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; 7,8,9,10 TETRAHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; CYTOCHROME P450 1A1; MEMBRANE PHOSPHOLIPID; MUTAGENIC AGENT; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL VACUOLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PURIFICATION; EPOXIDATION; HUMAN; INSECT CELL; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; TONOPLAST;

ANIMALS; CYTOCHROME P-450 CYP1A1; DIHYDROXYDIHYDROBENZOPYRENES; EPOXY COMPOUNDS; HUMANS; MEMBRANES, ARTIFICIAL; PHOSPHOLIPIDS; RECOMBINANT PROTEINS;

INSECTA;

EID: 85047697899     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.02848.x     Document Type: Article

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