EET homologs potently dilate coronary microvessels and activate BKCa channels

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 6 49-6, 2001, Pages

  Zhang, Yongde ^a   Oltman, Christine L ^b   Lu, Tong ^a   Lee, Hon Chi ^a,b   Dellsperger, Kevin C ^a,b   Vanrollins, Mike ^a  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Coronary microcirculation; Cytochrome P 450 epoxygenases; N 3 and n 6 polyunsaturated fatty acids

Indexed keywords

ARACHIDONIC ACID; EPOXYICOSATRIENOIC ACID; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; ENANTIOMER; ENDOTHELIUM CELL; HYPERPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; VASODILATATION;

EID: 0034979365     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.6.h2430     Document Type: Article

References (49)

1. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
2. Endothelium-derived hyperpolarizing factors and vascular cytochrome P-450 metabolites of arachidonic acid in the regulation of tone
3. Cytochrome P-450 arachidonic acid epoxygenase, Regulatory control of the renal epoxygenase by dietary salt loading
4. Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids
5. Synthesis of (±)-eicosa-cis-8,9-(11, 12- and 14,15-)epoxy-cis-11,14-(8,14- and 8,11-)dienoic acids and attempted bioconversion to prostaglandins
6. Fish consumption and the 30-year risk of fatal myocardial infarction
7. 3 cells
8. Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells
9. Cytochrome P-450 2C is an EDHF synthase in coronary arteries
10. Ca channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid
11. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle
12. An active site substitution, F87V, converts cytochrome P-450 BM-3 into a regio- and stereo-selective (14S,15R)-arachidonic acid epoxygenase
13. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
14. + channel in vascular smooth muscles by cytochrome P-450 metabolites of arachidonic acid
15. Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase
16. Arachidonic acid epoxygenase: Structural characterization and quantification of epoxyeicosatrienoates in plasma
17. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney
18. Urinary excretion of diols derived from eicosapentaenoic acid during n-3 fatty acid ingestion by man
19. Myogenic activity in isolated subepicardial and subendocardial coronary arterioles
20. Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes
21. + channels in coronary smooth muscle through a guanine nucleotide binding protein
22. Ca) channels
23. + channels in isolated coronary arterial myocytes
24. Anti-inflammatory properties of cytochrome P-450 epoxygenase-derived eicosanoids
25. Biosynthesis of prostaglandins from 17(18)epoxyeicosatetraenoic acid, a cytochrome P-450 metabolite of eicosapentaenoic acid
26. Metabolism of polyunsaturated (n-3) fatty acids by monkey seminal vesicles: Isolation and biosynthesis of ω-3 epoxides
27. Effects of glycosylated hemoglobin on vascular responses in vitro
28. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation
29. Is EDHF an epoxyeicosatrienoic acid?
30. ω-3 fatty acids in the prevention-management of cardiovascular disease
31. Ca channels in human coronary smooth muscle: Predominant α + β subunit complexes
32. Ca, a unique member of the voltage-gated K channel superfamily
33. Dietary fish oil and cytochrome P-450 monooxygenase activity in rat liver and kidney
34. Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis
35. Synthesis and characterization of cytochrome P-450 epoxygenase metabolites of eicosapentaenoic acid
36. Oxidation of docosahexaenoic acid by rat liver microsomes
37. Oxidation of 5,8,11,14,17-eicosapentaenoic acid by hepatic and renal microsomes
38. Arachidonic acid diols produced by cytochrome P-450 monooxygenases are incorporated into phospholipids of vascular endothelial cells
39. 14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells
40. Identification of arachidonate epoxides/diols by capillary chromatography-mass spectrometry
41. Optimization of epoxyeicosatrienoic acid synthases to test their effects on cerebral blood flow in vivo
42. + channels by endothelium-derived relaxing factors
43. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids
44. Molecular cloning and expression of CYP2J2, a human cytochrome P-450 arachidonic acid epoxygenase highly expressed in heart
45. Epoxyeicosatrienoic acid (EET) metabolism by cerebral endothelium
46. Reply: Cytochrome P-450-derived eicosanoids and the vascular wall
47. Direct resolution of epoxyeicosatrienoic acid enantiomers by chiral-phase high-performance liquid chromatography
48. Regio-specific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase
49. +-channel activity