Crystal structure of a conformation-selective casein kinase-1 inhibitor

Journal of Biological Chemistry

Volumn 275, Issue 26, 2000, Pages 20052-20060

  Mashhoon, Neda ^a   DeMaggio, Anthony J ^b   Tereshko, Valentina ^c   Bergmeier, Stephen C ^d   Egli, Martin ^d   Hoekstra, Merl F ^b   Kuret, Jeff ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(2,4,5 TRIMETHOXYPHENYL)METHYLIDENYL]INDOLIN 2 ONE; CASEIN KINASE I; IC 261; INDOLE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME STABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY;

CASEIN KINASES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INDOLES; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PHLOROGLUCINOL; PHOSPHOTRANSFERASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCES POMBE;

EID: 0034733572     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M001713200     Document Type: Article

References (55)

1. Gross, S. D., and Anderson, R. A. (1998) Cell. Signal. 10, 699-711
2. Vancura, A., Sessler, A., Leichus, B., and Kuret, J. (1994) J. Biol. Chem. 269, 19271-19278
3. Wang, P.-C., Vancura, A., Desai, A., Carmel, G., and Kuret, J. (1994) J. Biol. Chem. 269, 12014-12023
4. Gietzen, K. F., and Virshup, D. M. (1999) J. Biol. Chem. 274, 32063-32070
5. Hoekstra, M. F., Liskay, R. M., Ou, A. C., Demaggio, A. J., Burbee, D. G., and Heffron, F. (1991) Science 253, 1031-1034
6. Dhillon, N., and Hoekstra, M. F. (1994) EMBO J. 13, 2777-2787
7. Robinson, L. C., Menold, M. M., Garrett, S., and Culbertaon, M. R. (1993) Mol. Cell. Biol. 13, 2870-2881
8. Kloss, B., Price, J. L., Saez, L., Blau, J., Rothenfluh, A., Wesley, C. S., and Young, M. W. (1998) Cell 84, 97-107
9. Peters, J. M., McKay, R. M., McKay, J. P., and Graff, J. M. (1999) Nature 401, 345-350
10. Sakanaka, C., Leong, P., Xu, L., Harrison, S. D., and Williams, L. T. (1999) Proc. Natl. Acad. Sci. 96, 12548-12552
11. Decottignies, A., Owsianik, G., and Ghislain, M. (1999) J. Biol. Chem. 274, 37139-37146
12. Wang, X., Hoekstra, M. F., Demaggio, A. J., Dhillon, N., Vancura, A., Kuret, J., Johnston, G. C., and Singer, H. A. (1996) Mol. Cell. Biol. 16, 5375-5385
13. Panek, H. R., Stepp, J. D., Engle, H. M., Marks, K. M., Tan, P. K., Lemmon, S. K., and Robinson, L. C. (1996) EMBO J. 16, 4194-4204
14. Murakami, A., Kimura, K., and Nakano, A. (1998) J. Biol. Chem. 274, 3804-3810
15. Kuret, J., Johnson, G. S., Cha, D., Christenson, E. R., Demaggio, A. J., and Hoekstra, M. F. (1997) J. Neurochem. 69, 2506-2515
16. Ghoshal, N., Smiley, J. F., Demaggio, A. J., Hoekstra, M. F., Cochran, E. J., Binder, L. I., and Kuret, J. (1999) Am. J. Pathol. 155, 1163-1172
17. Schwab, C., Demaggio, A. J., Ghoshal, N., Binder, L. I., Kuret, J., and McGeer, P. L. (2000) Neurobiol. Aging 17, in press
18. Chyiwa, T., Hagiwara, M., and Hidaka, H. (1989) J. Biol. Chem. 264, 4924-4927
19. Hidaka, H., Hagiwara, M., and Chijiwa, T. (1991) Neurochem. Res. 15, 431-434
20. Meggio, P., Shugar, D., and Pinna, L. A. (1990) Eur. J. Biochem. 187, 89-94
21. Carmel, G., Leichus, B. Cheng, X., Patterson, S. D., Mirza, U., Chait, B. T., and Kuret, J. (1994) J. Biol. Chem. 269, 7304-7309
22. Xu, R., Carmel, G., Sweet, R. M., Kuret, J., and Cheng, X. (1995) EMBO J. 14, 1015-1023
23. Xu, R.-M., Carmel, G., Kuret, J., and Cheng, X. D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6308-6313
24. Kaczmarek, L. K., Jennings, K. R., Strumwasser, F., Nairn, A. C., Walter, U., Wilson, F. D., and Greengard, P. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 7487-7491
25. Mohammadi, M., Schlessinger, J., and Hubbard, S. R. (1996) Cell 86, 577-587
26. Hoekstra, M., Dhillon, N., Carmel, G., Demaggio, A. J., Lindberg, R. A., Hunter, T., and Kuret, J. (1994) Mol. Biol. Cell 5, 877-886
27. Casnellie, J. E. (1991) Methods Enzymol. 200, 115-120
28. Kemp, B. E., Graves, D. J., Benjamini, E., and Krebs, E. G. (1977) J. Biol. Chem. 252, 4888-4894
29. Beaudette, K. N., Lew, J., and Wang, J. H. (1993) J. Biol. Chem. 268, 20825-20830
30. Cheng, H. C., Nishio, H., Hatase, O., Ralph, S., and Wang, J. H. (1992) J. Biol. Chem. 267, 9248-9256
31. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
32. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
33. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
34. Brunger, A. T. (1992a) Nature 355, 472-475
35. Jones, T. A. (1985) Methods Enzymol. 115, 157-171
36. Cambillau, C., and Rossel, A. (1997) Turbo Fordo, Version OpenGL. 1, Universite Aaix-Marseille II, Marseille, France
37. Kleywegt, G. J., and Jones, T. A. (1997) Methods Enzymol. 277, 208-230
38. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
39. Brünger, A. T. (1992) X-PLOR, version 3.1, Yale University Press, New Haven, CT
40. Wriggers, W., and Schulten, K. (1997) Proteins Struct. Funct. Genet. 29, 1-14
41. Sreerama, N., and Woody, R. W. (1993) Anal. Biochem. 209, 32-44
42. Santoro, M. M., and Bolen, D. W. (1988) Biochemistry 27, 8063-8068
43. Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., and Schlessinger, J. (1997) Science 276, 955-960
44. Sun, L., Tran, N., Tang, F., App, H., Hirth, P., McMahon, G., and Tang, C. (1998) J. Med. Chem. 41, 2588-2603
45. Thomas, K. A., Smith, G. M., Thomas, T. B., and Feldman, R. J. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 4843-4847
46. Knippschild, U., Milne, D. M., Campbell, L. E., Demaggio, A. J., Christenson, E., Hoekstra, M. F., and Meek, D. W. (1997) Oncogene 15, 1727-1736
47. Engh, R. A., Girod, A., Kinzel, V., Huber, R., and Bossemeyer, D. (1996) J. Biol. Chem. 271, 26157-26164
48. Foster, B. A., Coffey, H. A., Morin, M. J., and Rastinejad, F. (1999) Science 286, 2507-2510
49. Williams, J. C., Weijland, A., Gonfloni, S., Thompson, A., Courneige, S. A., Superti-Furga, G., and Wierenga, R. K. (1997) J. Mol. Biol. 274, 757-775
50. Johnson, L. N., Lowe, E. D., Noble, M. E. M., and Owen, D. J. (1998) FEBS Lett. 430, 1-11
51. Longenecker, K. L., Roach, P. J., and Hurley, T. D. (1996) J. Mol. Biol. 257, 618-631
52. Zheng, J., Knighton, D. R., Xuong, N.-H., Taybr, S. S., Sowadski, J. M., and Ten Eyck, L. F. (1993) Protein Sci. 2, 1559-1573
53. Naryana, N., Cox, S., Nguyen-huu, X., Ten Eyck, L. F., and Taylor, S. S. (1997) Structure 5, 921-935
54. Prade, L., Engh, R. A., Girod, A., Kinzel, V., Huber, R., and Bossemeyer, D. (1997) Structure 5, 1627-1637
55. Penn, R. B., Parent, J.-L., Pronin, A. N., Panettieri, R. A., and Benovic, J. L. (1999) J. Pharmacol. Exp. Ther. 288, 428-437