Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: Insights into kinase mechanism

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10049-10055

  Till, Jeffrey H ^a   Ablooglu, Ararat J ^b   Frankel, Mark ^b   Bishop, Steven M ^b,c   Kohanski, Ronald A ^b   Hubbard, Stevan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; INSULIN; SUBSTRATES; VISCOSITY MEASUREMENT;

AUTOINHIBITION;

ENZYMES;

ADENOSINE TRIPHOSPHATE; ALANINE; ASPARTIC ACID; INSULIN RECEPTOR; INSULIN RECEPTOR TYROSINE KINASE; PEPTIDE; PHENYLALANINE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; GUANIDINE;

ALPHA HELIX; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; PRIORITY JOURNAL; PROTEIN MOTIF; STEREOCHEMISTRY; VISCOMETRY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; GENETICS; HYDROGEN BOND; KINETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN TERTIARY STRUCTURE; SPECTROFLUOROMETRY; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID MOTIFS; ANIMALS; ASPARTIC ACID; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GUANIDINE; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTATION; PHENYLALANINE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTOR, INSULIN; SPECTROMETRY, FLUORESCENCE;

EID: 0035971245     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010161200     Document Type: Article

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