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Volumn 49, Issue 5, 2000, Pages 701-707

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; DEUTERIUM; FATTY ACID; GLUCAGON; GLUCOSE; GLYCEROL; GROWTH HORMONE; HEPARIN; HYDROCORTISONE; INSULIN; INTRALIPID; LACTIC ACID;

EID: 0034072554     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.5.701     Document Type: Article
Times cited : (234)

References (49)
  • 2
    • 0024244339 scopus 로고
    • Measurement of plasma glucose free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD: Measurement of plasma glucose free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37:1020-1024, 1988
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.Y.3    Wu, M.S.4    Chen, Y.D.5
  • 3
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
    • Perseghin G, Ghosh S, Gerow K, Shulman GI: Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 46:1001-1009, 1997
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 4
    • 0026468362 scopus 로고
    • What if minkowski had been ageusic? An alternative angle on diabetes
    • McGarry JD: What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770, 1992
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 5
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:13-10, 1997
    • (1997) Diabetes , vol.46 , pp. 13-110
    • Boden, G.1
  • 6
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • Kelley DE, Mokan M, Simoneau JA, Mandarino LJ: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92:91-98, 1993
    • (1993) J Clin Invest , vol.92 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3    Mandarino, L.J.4
  • 9
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
    • Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D: Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest 74:1238-1246, 1984
    • (1984) J Clin Invest , vol.74 , pp. 1238-1246
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3    Reaven, G.4    Mott, D.5
  • 10
    • 0025963777 scopus 로고
    • The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes niellitus
    • Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA: The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes niellitus. J Clin Endocrinol Metab 72:96-107, 1991
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 96-107
    • Groop, L.C.1    Saloranta, C.2    Shank, M.3    Bonadonna, R.C.4    Ferrannini, E.5    DeFronzo, R.A.6
  • 14
    • 0025872319 scopus 로고
    • Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources
    • Yki-Järvinen H, Puhakainen I, Saloranta C, Groop L, Taskinen MR: Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. Am J Physiol 260:E680-E689, 1991
    • (1991) Am J Physiol , vol.260
    • Yki-Järvinen, H.1    Puhakainen, I.2    Saloranta, C.3    Groop, L.4    Taskinen, M.R.5
  • 15
    • 0025775034 scopus 로고
    • Effects of lipid on basal carbohydrate metabolism in normal men
    • Boden G, Jadali F: Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes 40:686-692, 1991
    • (1991) Diabetes , vol.40 , pp. 686-692
    • Boden, G.1    Jadali, F.2
  • 16
    • 0026005773 scopus 로고
    • In vivo evidence for hepatic autoregulation during FFA-stimulaled gluconeogenesis in normal humans
    • Clore JN, Glickman PS, Nestler JE, Blackard WG: In vivo evidence for hepatic autoregulation during FFA-stimulaled gluconeogenesis in normal humans. Am J Physiol 261:E425-E429, 1991
    • (1991) Am J Physiol , vol.261
    • Clore, J.N.1    Glickman, P.S.2    Nestler, J.E.3    Blackard, W.G.4
  • 17
    • 0026644792 scopus 로고
    • Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects
    • Fulcher GR, Walker M, Catalano C, Agius L, Alberti KG: Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects. Diabetes 41:1400-1408, 1992
    • (1992) Diabetes , vol.41 , pp. 1400-1408
    • Fulcher, G.R.1    Walker, M.2    Catalano, C.3    Agius, L.4    Alberti, K.G.5
  • 18
    • 0032905885 scopus 로고    scopus 로고
    • The effect of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
    • Chen X, Iqbal N, Boden G: The effect of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest 103:305-372, 1999
    • (1999) J Clin Invest , vol.103 , pp. 305-372
    • Chen, X.1    Iqbal, N.2    Boden, G.3
  • 19
    • 0025949378 scopus 로고
    • Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Skött P, Gall M-A, Richter EA, Beck-Nielsen H: Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 88:1282-1290, 199I
    • (1991) J Clin Invest , vol.88 , pp. 1282-1290
    • Vaag, A.1    Skött, P.2    Gall, M.-A.3    Richter, E.A.4    Beck-Nielsen, H.5
  • 20
    • 0027515569 scopus 로고
    • Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM
    • Puhakainen I, Yki-Järvinen H: Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM. Diabetes 42:1694-1699, 1993
    • (1993) Diabetes , vol.42 , pp. 1694-1699
    • Puhakainen, I.1    Yki-Järvinen, H.2
  • 22
    • 0027358353 scopus 로고
    • Gluconeogenesis in type 2 diabetes
    • Gerich JE, Nurjhan N: Gluconeogenesis in type 2 diabetes. Adv Exp Med Biol 334:253-258, 1993
    • (1993) Adv Exp Med Biol , vol.334 , pp. 253-258
    • Gerich, J.E.1    Nurjhan, N.2
  • 23
    • 0029897538 scopus 로고    scopus 로고
    • Role of fat-derived substrates in the regulation of gluconeogenesis during fasting
    • Fery F, Plat L, Melot C, Balasse EO: Role of fat-derived substrates in the regulation of gluconeogenesis during fasting. Am J Physiol 270:E822-E830, 1996
    • (1996) Am J Physiol , vol.270
    • Fery, F.1    Plat, L.2    Melot, C.3    Balasse, E.O.4
  • 24
    • 0019987653 scopus 로고
    • Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus
    • Waldhäusl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P: Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus. Diabelologia 23:6-15, 1982
    • (1982) Diabelologia , vol.23 , pp. 6-15
    • Waldhäusl, W.1    Bratusch-Marrain, P.2    Gasic, S.3    Korn, A.4    Nowotny, P.5
  • 25
    • 0027487855 scopus 로고
    • Estimating gluconeogenic rates in NIDDM
    • Landau BR: Estimating gluconeogenic rates in NIDDM. Adv Exp Med Biol 334:205-220, 1992
    • (1992) Adv Exp Med Biol , vol.334 , pp. 205-220
    • Landau, B.R.1
  • 32
    • 0018087989 scopus 로고
    • Combined 17- and 18-hydroxylase deficiency associated with complete male pseudohermaphroditism and hypoaldosteronism
    • Waldhäusl W, Herkner K, Nowotny P, Bratusch-Marrain P: Combined 17- and 18-hydroxylase deficiency associated with complete male pseudohermaphroditism and hypoaldosteronism. J Clin Endocrinol Metab 46:236-240, 1978
    • (1978) J Clin Endocrinol Metab , vol.46 , pp. 236-240
    • Waldhäusl, W.1    Herkner, K.2    Nowotny, P.3    Bratusch-Marrain, P.4
  • 33
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Cgen X, Rosner J, Barton M: Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44:1239-1242, 1995
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Cgen, X.2    Rosner, J.3    Barton, M.4
  • 34
    • 0014251318 scopus 로고
    • Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin
    • Pelkonen R, Miettinen TA, Taskinen M-R, Nikkila EA: Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin. Diabetes 17:76-82, 1968
    • (1968) Diabetes , vol.17 , pp. 76-82
    • Pelkonen, R.1    Miettinen, T.A.2    Taskinen, M.-R.3    Nikkila, E.A.4
  • 36
    • 0014789878 scopus 로고
    • Portal and peripheral vein immunoreactive insulin concentrations before and after glucose infusion
    • Blackard WG, Nelson NC: Portal and peripheral vein immunoreactive insulin concentrations before and after glucose infusion. Diabetes 19:302-306, 1970
    • (1970) Diabetes , vol.19 , pp. 302-306
    • Blackard, W.G.1    Nelson, N.C.2
  • 37
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus: Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA: Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus: evidence for multiple sites of insulin resistance. J Clin Invest 84:205-213, 1989
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    DeFronzo, R.A.7
  • 38
    • 0032902368 scopus 로고    scopus 로고
    • Effect of a selective rise in hepatic artery insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Igawa K, Chu CA, Balcom JH, Neal DW, Cherrington AD: Effect of a selective rise in hepatic artery insulin on hepatic glucose production in the conscious dog. Am J Physiol 276:E806-E813, 1999
    • (1999) Am J Physiol , vol.276
    • Sindelar, D.K.1    Igawa, K.2    Chu, C.A.3    Balcom, J.H.4    Neal, D.W.5    Cherrington, A.D.6
  • 40
    • 0023026312 scopus 로고
    • Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans
    • Nurjhan N, Campbell PJ, Kennedy FP, Miles JM, Gerich JE: Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans. Diabetes 35:1326-1331, 1986
    • (1986) Diabetes , vol.35 , pp. 1326-1331
    • Nurjhan, N.1    Campbell, P.J.2    Kennedy, F.P.3    Miles, J.M.4    Gerich, J.E.5
  • 41
    • 0032810949 scopus 로고    scopus 로고
    • A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo
    • Previs S, Cline GW, Shulman GI: A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo. Am J Physiol 277:E154-E160, 1999
    • (1999) Am J Physiol , vol.277
    • Previs, S.1    Cline, G.W.2    Shulman, G.I.3
  • 42
    • 0016583677 scopus 로고
    • Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus
    • Wahren J, Hagenfeldt L, Felig P: Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J Clin Invest 55:1303-1314, 1975
    • (1975) J Clin Invest , vol.55 , pp. 1303-1314
    • Wahren, J.1    Hagenfeldt, L.2    Felig, P.3
  • 43
    • 0031060687 scopus 로고    scopus 로고
    • In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase
    • Bahl JJ, Matsuda M, DeFronzo KA, Bressler R: In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase. Biochem Pharmacol 53:67-74, 1997
    • (1997) Biochem Pharmacol , vol.53 , pp. 67-74
    • Bahl, J.J.1    Matsuda, M.2    DeFronzo, K.A.3    Bressler, R.4
  • 44
    • 0025346223 scopus 로고
    • Enhancement of hepatic glycogen by gluconeogenic precursois: Substrate flux or metabolic control?
    • Youn H, Bergman RN: Enhancement of hepatic glycogen by gluconeogenic precursois: substrate flux or metabolic control? Am J Physiol 258:E899-E906, 1990
    • (1990) Am J Physiol , vol.258
    • Youn, H.1    Bergman, R.N.2
  • 45
    • 0032737027 scopus 로고    scopus 로고
    • Origins of the hydrogen bound to carbon 1 of glucose in fasting: Significance in gluconeogenesis quantitation
    • Chandramouli V, Ekberg K, Schumann WC, Wahren J, Landau BR: Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation. Am J Physiol 277:E717-E723, 1999
    • (1999) Am J Physiol , vol.277
    • Chandramouli, V.1    Ekberg, K.2    Schumann, W.C.3    Wahren, J.4    Landau, B.R.5
  • 46
    • 0032520870 scopus 로고    scopus 로고
    • Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
    • Peterson KF, Laurent D, Rothman DL, Cline GW, Shulman GI: Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 101:1203-1209, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1203-1209
    • Peterson, K.F.1    Laurent, D.2    Rothman, D.L.3    Cline, G.W.4    Shulman, G.I.5
  • 49
    • 0028825129 scopus 로고
    • Free fatty acids as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN: Free fatty acids as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045, 1995
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.