Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes

Diabetes

Volumn 50, Issue 4, 2001, Pages 810-816

  Boden, Guenther ^a,b   Chen, Xinhua ^a   Capulong, Edwin ^a   Mozzoli, Maria ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOREGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCONEOGENESIS; GLYCOGENOLYSIS; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0035082482     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.4.810     Document Type: Article

References (32)

1. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
2. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
3. Effect of lipids on basal carbohydrate metabolism in normal men
4. Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men
5. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
6. Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans: Demonstration of hepatic autoregulation without a change in plasma glucose concentration
7. Non-esterified fatty acids in blood of obese and lean subjects
8. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
9. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
10. Quantifying gluconeogenesis during fasting
11. Contributions of gluconeogenesis to glucose production in the fasted state
12. 14C-labeled substrates
13. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
14. Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type 1 diabetic patients
15. Prehepatic insulin production in man: Kinetic analysis using peripheral connecting peptide behavior
16. 3H]glucose infusion
17. In vivo and in vitro effects of anti-insulin receptor antibodies
18. Measurement of size and turnover rate of body glucose pool by the isotope dilution method
19. Methods for the assessment of human body composition: Traditional and new
20. Gluconeogenesis (GNG) in moderately and severely hyperglycemic patients with type 2 diabetes
21. Increased rate of gluconeogenesis in type II diabetes mellitus
22. Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans
23. Examination of in vivo effects of nicotinic acid on basal and hormone-stimulated glycogenolysis, gluconeogenesis, ureogenesis and ketogenesis in the isolated perfused rat liver
24. Effects of growth hormone on insulin action in man: Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization
25. Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
26. 13C NMR
27. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
28. Increased lipolysis and its consequences on gluconeo-genesis in non-insulin-dependent diabetes mellitus
29. Effects of hepatic glycogen content on hepatic insulin action in humans: Alteration in the relative contributions of glycogenolysis and gluconeo-genesis to endogenous glucose production
30. Control of hepatic glycogenolysis
31. Thiazolidinediones in the treatment of insulin resistance and type II diabetes