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Volumn 284, Issue 2 47-2, 2003, Pages

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites

Author keywords

Glucokinase; Glucose cycling; Glucose 6 phosphatase; Total glucose output

Indexed keywords

C PEPTIDE; FATTY ACID; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLYCEROL; HEPARIN; INSULIN; INTRALIPID; SODIUM CHLORIDE; TRIACYLGLYCEROL;

EID: 0037303077     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00332.2002     Document Type: Article
Times cited : (131)

References (51)
  • 2
    • 0031049330 scopus 로고    scopus 로고
    • Binding and translocation of glucokinase in hepatocytes
    • Agius L and Peak M. Binding and translocation of glucokinase in hepatocytes. Biochem Soc Trans 25: 145-150, 1997.
    • (1997) Biochem Soc Trans , vol.25 , pp. 145-150
    • Agius, L.1    Peak, M.2
  • 3
    • 0027358817 scopus 로고
    • Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin
    • Barzilai N and Rossetti L. Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin. J Biol Chem 268: 25019-25025, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 25019-25025
    • Barzilai, N.1    Rossetti, L.2
  • 4
    • 0022857823 scopus 로고
    • Assessment of insulin action in insulin- dependent diabetes mellitus using [6(14)C]glucose, [3(3)H]glucose, and [2(3)H]glucose. Differences in the apparent pattern of insulin resistance depending on the isotope used
    • Bell PM, Firth RG, and Rizza RA. Assessment of insulin action in insulin- dependent diabetes mellitus using [6(14)C]glucose, [3(3)H]glucose, and [2(3)H]glucose. Differences in the apparent pattern of insulin resistance depending on the isotope used. J Clin Invest 78: 1479-1486, 1986.
    • (1986) J Clin Invest , vol.78 , pp. 1479-1486
    • Bell, P.M.1    Firth, R.G.2    Rizza, R.A.3
  • 5
    • 0027500306 scopus 로고
    • Effects of fatty acid oxidation on glucose utilization by isolated hepatocytes
    • Berry MN, Phillips JW, Henly DC, and Clark DG. Effects of fatty acid oxidation on glucose utilization by isolated hepatocytes. FEBS Lett 319: 26-30, 1993.
    • (1993) FEBS Lett , vol.319 , pp. 26-30
    • Berry, M.N.1    Phillips, J.W.2    Henly, D.C.3    Clark, D.G.4
  • 6
    • 0030847364 scopus 로고    scopus 로고
    • Meal-induced changes in hepatic glycogen of fasted rats
    • Beverly JL, Yang ZJ, Koseki M, and Meguid MM. Meal-induced changes in hepatic glycogen of fasted rats. Physiol Behav 62: 1093-1098, 1997.
    • (1997) Physiol Behav , vol.62 , pp. 1093-1098
    • Beverly, J.L.1    Yang, Z.J.2    Koseki, M.3    Meguid, M.M.4
  • 7
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 8
    • 0017889365 scopus 로고
    • Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone
    • Bontemps F, Hue L, and Hers HG. Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone. Biochem J 174: 603-611, 1978.
    • (1978) Biochem J , vol.174 , pp. 603-611
    • Bontemps, F.1    Hue, L.2    Hers, H.G.3
  • 9
    • 0027085687 scopus 로고
    • Regulation of free fatty acid metabolism by insulin in humans: Role of lipolysis and reesterification
    • Campbell PJ, Carlson MG, Hill JO, and Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol Endocrinol Metab 263: E1063-E1069, 1992.
    • (1992) Am J Physiol Endocrinol Metab , vol.263
    • Campbell, P.J.1    Carlson, M.G.2    Hill, J.O.3    Nurjhan, N.4
  • 10
    • 0026005773 scopus 로고
    • In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans
    • Clore JN, Glickman PS, Nestler JE, and Blackard WG. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol Endocrinol Metab 261: E425-E429, 1991.
    • (1991) Am J Physiol Endocrinol Metab , vol.261
    • Clore, J.N.1    Glickman, P.S.2    Nestler, J.E.3    Blackard, W.G.4
  • 11
    • 0033972763 scopus 로고    scopus 로고
    • Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats
    • Corsetti JP, Sparks JD, Peterson RG, Smith RL, and Sparks CE. Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis 148: 231-241, 2000.
    • (2000) Atherosclerosis , vol.148 , pp. 231-241
    • Corsetti, J.P.1    Sparks, J.D.2    Peterson, R.G.3    Smith, R.L.4    Sparks, C.E.5
  • 12
    • 0020684724 scopus 로고
    • Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man
    • DeFronzo RA, Ferrannini E, Hendler R, Felig P, and Wahren J. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32: 35-45, 1983.
    • (1983) Diabetes , vol.32 , pp. 35-45
    • DeFronzo, R.A.1    Ferrannini, E.2    Hendler, R.3    Felig, P.4    Wahren, J.5
  • 14
    • 0023928903 scopus 로고
    • Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity
    • Efendic S, Karlander S, and Vranic M. Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity. J Clin Invest 81:1953-1961, 1988.
    • (1988) J Clin Invest , vol.81 , pp. 1953-1961
    • Efendic, S.1    Karlander, S.2    Vranic, M.3
  • 15
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, and Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36: 914-924, 1987.
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 16
    • 0030851975 scopus 로고    scopus 로고
    • Effect of feeding, fasting, and diabetes on liver glycogen synthase activity, protein, and mRNA in rats
    • Gannon MC and Nuttall FQ. Effect of feeding, fasting, and diabetes on liver glycogen synthase activity, protein, and mRNA in rats. Diabetologia 40: 758-763, 1997.
    • (1997) Diabetologia , vol.40 , pp. 758-763
    • Gannon, M.C.1    Nuttall, F.Q.2
  • 17
    • 0027370115 scopus 로고
    • The role of glucose-6- phosphatase in the action of insulin on hepatic glucose production in the rat
    • Gardner LB, Liu Z, and Barrett EJ. The role of glucose-6-phosphatase in the action of insulin on hepatic glucose production in the rat. Diabetes 42: 1614-1620, 1993.
    • (1993) Diabetes , vol.42 , pp. 1614-1620
    • Gardner, L.B.1    Liu, Z.2    Barrett, E.J.3
  • 18
    • 0021989805 scopus 로고
    • A comparison of the influence of diets high in saturated versus unsaturated fatty acids on lipid composition and glucose-6-phosphatase activity of rat liver microsomes
    • Garg ML, Sabine JR, and Snoswell AM. A comparison of the influence of diets high in saturated versus unsaturated fatty acids on lipid composition and glucose-6-phosphatase activity of rat liver microsomes. Biochem Int 10: 585-595, 1985.
    • (1985) Biochem Int , vol.10 , pp. 585-595
    • Garg, M.L.1    Sabine, J.R.2    Snoswell, A.M.3
  • 19
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, and Vranic M. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90: 1769-1777, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.J.2    Shi, Z.Q.3    Gupta, R.4    Lickley, H.L.5    Vranic, M.6
  • 20
    • 0031671077 scopus 로고    scopus 로고
    • Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia
    • Giacca A, Groenewoud Y, Tsui E, McClean P, and Zinman B. Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes 47: 1763-1770, 1998.
    • (1998) Diabetes , vol.47 , pp. 1763-1770
    • Giacca, A.1    Groenewoud, Y.2    Tsui, E.3    McClean, P.4    Zinman, B.5
  • 21
    • 0026020099 scopus 로고
    • Hormonal regulation of liver phosphoenolpyruvate carboxykinase and glucokinase gene expression at weaning in the rat
    • Girard J, Perdereau D, Narkewicz M, Coupe C, Ferre P, Decaux JF, and Bossard P. Hormonal regulation of liver phosphoenolpyruvate carboxykinase and glucokinase gene expression at weaning in the rat. Biochimie 73: 71-76, 1991.
    • (1991) Biochimie , vol.73 , pp. 71-76
    • Girard, J.1    Perdereau, D.2    Narkewicz, M.3    Coupe, C.4    Ferre, P.5    Decaux, J.F.6    Bossard, P.7
  • 23
    • 0029282573 scopus 로고
    • Impaired muscle fat metabolism: A cause or effect of visceral obesity?
    • Henry RR. Impaired muscle fat metabolism: a cause or effect of visceral obesity? J Clin Invest 95: 1427-1428, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 1427-1428
    • Henry, R.R.1
  • 24
    • 0028214097 scopus 로고
    • Coordinate regulation of glycolytic and lipogenic gene expression by polyun-saturated fatty acids
    • Jump DB, Clarke SD, Thelen A, and Liimatta M. Coordinate regulation of glycolytic and lipogenic gene expression by polyun-saturated fatty acids. J Lipid Res 35: 1076-1084, 1994.
    • (1994) J Lipid Res , vol.35 , pp. 1076-1084
    • Jump, D.B.1    Clarke, S.D.2    Thelen, A.3    Liimatta, M.4
  • 25
    • 0018257924 scopus 로고
    • A method for the determination of glucose- 6- phosphatase activity in rat liver with [U-14C]glucose 6-phosphate as substrate
    • Kitcher SA, Siddle K, and Luzio JP. A method for the determination of glucose- 6- phosphatase activity in rat liver with [U-14C]glucose 6-phosphate as substrate. Anal Biochem 88: 29-36, 1978.
    • (1978) Anal Biochem , vol.88 , pp. 29-36
    • Kitcher, S.A.1    Siddle, K.2    Luzio, J.P.3
  • 28
    • 0028287877 scopus 로고
    • Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP
    • Lange AJ, Argaud D, el Maghrabi MR, Pan W, Maitra SR, and Pilkis SJ. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem Biophys Res Commun 201: 302-309, 1994.
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 302-309
    • Lange, A.J.1    Argaud, D.2    El Maghrabi, M.R.3    Pan, W.4    Maitra, S.R.5    Pilkis, S.J.6
  • 29
    • 0033627857 scopus 로고    scopus 로고
    • Glycogen content in rat liver. Importance for CT and MR imaging
    • Leander P, Mansson S, and Pettersson G. Glycogen content in rat liver. Importance for CT and MR imaging. Acta Radiol 41: 92-96, 2000.
    • (2000) Acta Radiol , vol.41 , pp. 92-96
    • Leander, P.1    Mansson, S.2    Pettersson, G.3
  • 30
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229, 2002.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 31
    • 0033766420 scopus 로고    scopus 로고
    • Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats
    • Mason TM, Gupta N, Goh T, El Bahrani B, Zannis J, van de Werve G, and Giacca A. Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats. Metabolism 49:1411-1416, 2000.
    • (2000) Metabolism , vol.49 , pp. 1411-1416
    • Mason, T.M.1    Gupta, N.2    Goh, T.3    El Bahrani, B.4    Zannis, J.5    Van de Werve, G.6    Giacca, A.7
  • 32
  • 33
    • 0031882245 scopus 로고    scopus 로고
    • Glucose-fatty acid interactions in health and disease
    • McGarry JD. Glucose-fatty acid interactions in health and disease. Am J Clin Nutr 67: 500S-504S, 1998.
    • (1998) Am J Clin Nutr , vol.67
    • McGarry, J.D.1
  • 34
    • 0028811226 scopus 로고
    • Liver glucose- 6 phosphatase activity is inhibited by refeeding in rats
    • Minassian C, Daniele N, Bordet JC, Zitoun C, and Mithieux G. Liver glucose-6 phosphatase activity is inhibited by refeeding in rats. J Nutr 125: 2727-2732, 1995.
    • (1995) J Nutr , vol.125 , pp. 2727-2732
    • Minassian, C.1    Daniele, N.2    Bordet, J.C.3    Zitoun, C.4    Mithieux, G.5
  • 35
    • 0032523023 scopus 로고    scopus 로고
    • Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin
    • Minassian C, Tarpin S, and Mithieux G. Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin. Biochem Pharmacol 55: 1213-1219, 1998.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1213-1219
    • Minassian, C.1    Tarpin, S.2    Mithieux, G.3
  • 36
    • 0030049678 scopus 로고    scopus 로고
    • Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphatase in intact and detergent-treated rat liver microsomes
    • Mithieux G and Zitoun C. Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphatase in intact and detergent-treated rat liver microsomes. Eur J Biochem 235: 799-803, 1996.
    • (1996) Eur J Biochem , vol.235 , pp. 799-803
    • Mithieux, G.1    Zitoun, C.2
  • 37
    • 0012756635 scopus 로고
    • Types of photometer
    • edited by Bergmeyer HU. San Diego, CA: Academic
    • a. Netheler HG. Types of photometer. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. San Diego, CA: Academic, 1974, p. 184-185.
    • (1974) Methods of Enzymatic Analysis , pp. 184-185
    • Netheler, H.G.1
  • 38
    • 0017154480 scopus 로고
    • Substrate cycles in metabolic regulation and in heat generation
    • Newsholme EA and Crabtree B. Substrate cycles in metabolic regulation and in heat generation. Biochem Soc Symp 41: 61-109, 1976.
    • (1976) Biochem Soc Symp , vol.41 , pp. 61-109
    • Newsholme, E.A.1    Crabtree, B.2
  • 39
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, and Kraegen EW. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46: 1768-1774, 1997.
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 40
    • 0029049346 scopus 로고
    • A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
    • Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, and Ravussin E. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38: 1213-1217, 1995.
    • (1995) Diabetologia , vol.38 , pp. 1213-1217
    • Paolisso, G.1    Tataranni, P.A.2    Foley, J.E.3    Bogardus, C.4    Howard, B.V.5    Ravussin, E.6
  • 41
    • 0037013275 scopus 로고    scopus 로고
    • Polyunsaturated fatty acyl coenzyme A suppress the glucose-6- phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha
    • Rajas F, Gautier A, Bady I, Montano S, and Mithieux G. Polyunsaturated fatty acyl coenzyme A suppress the glucose-6- phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha. J Biol Chem 277: 15736- 15744, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 15736-15744
    • Rajas, F.1    Gautier, A.2    Bady, I.3    Montano, S.4    Mithieux, G.5
  • 43
    • 0027199061 scopus 로고
    • Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes
    • Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest 92: 1126-1134, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 1126-1134
    • Rossetti, L.1    Giaccari, A.2    Barzilai, N.3    Howard, K.4    Sebel, G.5    Hu, M.6
  • 45
    • 0028586027 scopus 로고
    • Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog
    • Shi ZQ, Giacca A, Fisher S, Vidal H, van de Werve G, and Vranic M. Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog. Diabetes 43: 1284-1290, 1994.
    • (1994) Diabetes , vol.43 , pp. 1284-1290
    • Shi, Z.Q.1    Giacca, A.2    Fisher, S.3    Vidal, H.4    Van de Werve, G.5    Vranic, M.6
  • 46
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Balcom JH, Chu CA, Neal DW, and Cherrington AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604, 1996.
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 47
    • 0019837530 scopus 로고
    • Hormone-induced effects on the rat liver microsomal glucose-6-phosphatase system in vitro
    • Speth M and Schulze HU. Hormone-induced effects on the rat liver microsomal glucose-6-phosphatase system in vitro. Biochem Biophys Res Commun 99: 134-141, 1981.
    • (1981) Biochem Biophys Res Commun , vol.99 , pp. 134-141
    • Speth, M.1    Schulze, H.U.2
  • 48
    • 0000992063 scopus 로고
    • Rates of glucose oxidation in normal and diabetic rats
    • Stetten DW, Welt ID, Ingle DJ, and Morley EH. Rates of glucose oxidation in normal and diabetic rats. J Biol Chem 192: 817-830, 1951.
    • (1951) J Biol Chem , vol.192 , pp. 817-830
    • Stetten, D.W.1    Welt, I.D.2    Ingle, D.J.3    Morley, E.H.4
  • 49
    • 0020479806 scopus 로고
    • Specific inhibition of glucokinase by long chain acyl coenzyme A below the critical micelle concentration
    • Tippett PS and Neet KE. Specific inhibition of glucokinase by long chain acyl coenzyme A below the critical micelle concentration. J Biol Chem 257: 12839-12845, 1982.
    • (1982) J Biol Chem , vol.257 , pp. 12839-12845
    • Tippett, P.S.1    Neet, K.E.2
  • 50
    • 0024522508 scopus 로고
    • Liver glucose-6-phosphatase activity is modulated by physiological intracellular Ca2 + concentrations
    • Van de Werve G. Liver glucose-6-phosphatase activity is modulated by physiological intracellular Ca2 + concentrations. J Biol Chem 264:6033-6036, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 6033-6036
    • Van de Werve, G.1


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