Phylogenetic and functional classification of mitogen- and stress- activated protein kinases

Journal of Molecular Evolution

Volumn 46, Issue 5, 1998, Pages 571-588

  Kültz, Dietmar ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Evolution; Extracellular signal regulated kinase; Mitogen activated protein kinase; Phosphorylation; Signal transduction; Signature sequence; Stress activated protein kinase; Structure

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

AMINO ACID SEQUENCE; ARTICLE; DNA SEQUENCE; ENZYME STRUCTURE; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING; PHYLOGENY; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CONSERVED SEQUENCE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHYLOGENY; PROTEIN CONFORMATION; RATS; SEQUENCE ALIGNMENT;

EID: 0031900639     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00006338     Document Type: Article

References (89)

1. Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee JD (1996) Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem 271:16586-16590
2. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
3. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389-3402
4. Appel RD, Bairoch A, Hochstrasser DF (1994) A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server. Trends Biochem Sci 19:258-260
5. Bokemeyer D, Sorokin A, Yan MH, Ahn NG, Templeton DJ, Dunn MJ (1996) Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts. J Biol Chem 271:639-642
6. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, Depinho RA, Panayotatos N, Cobb MH, Yancopoulos GD (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675
7. Brunet A, Pouyssegur J (1996) Identification of MAP kinase domains by redirecting stress signals into growth factor responses. Science 272:1652-1655
8. Burg MB, Kwon ED, Kültz D (1996) Osmotic regulation of gene expression. FASEB J 10:1598-1606
9. Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ (1997) Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 90:859-869
10. Charest DL, Mordret G, Harder KW, Jirik F, Pelech SL (1993) Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44ERK1. Mol Cell Biol 13:4679-4690
11. Cheng M, Boulton TG, Cobb MH (1996a) ERK3 is a constitutively nuclear protein kinase. J Biol Chem 271:8951-8958
12. Cheng M, Zhen E, Cobb MH (1996b) Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3. J Biol Chem 271:12057-12062
13. Clark-Lewis I, Sanghera JS, Pelech SL (1991) Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. J Biol Chem 266: 15180-15184
14. Cobb MH, Goldsmith EJ (1995) How MAP kinases are regulated. J Biol Chem 270:14843-14846
15. Cohen P (1997) The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 7:353-361
16. Cuenda A, Cohen P, Bueé-Scherrer V, Goedert M (1997) Activation of stress-activated protein kinase 3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6): comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 16:295-305
17. Dayhoff MO, Schwartz RM, Orcutt BC (1978) Atlas of protein sequence and structure. National Biomedical Research Foundation, Washington DC
18. Decroocq-Ferrant V, Decroocq S, Van WJ, Schmidt E, Kreis M (1995) A homologue of the MAP/ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida. Plant Mol Biol 27:339-350
19. Dérijard B, Hibi M, Wu I-H, Barrett T, Su B, Deng T, Karin M, Davis RJ (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037
20. Ferrell JE Jr (1996) MAP kinases in mitogenesis and development. Curr Top Dev Biol 33:1-60
21. Fukunaga R, Hunter T (1997) Mnk1, a new MAP kinase-activated protein-kinase, isolated by a novel expression screening method for identifying protein-kinase substrates. EMBO J 16:1921-1933
22. Galcheva-Gargova Z, Dérijard B, Wu IH, Davis RJ (1994) An osmosensing signal transduction pathway in mammalian cells. Science 265:806-808
23. Gartner A, Nasmyth K, Ammerer G (1992) Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1. Genes Dev 6:1280-1292
24. Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (1997a) Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6): comparison of its substrate-specificity with that of other SAP kinases. EMBO J 16:3563-3571
25. Goedert M, Hasegawa J, Craxton M, Leversha MA, Clegg S (1997b) Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. Genomics 41:501-502
26. Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992) Heterogeneous expression of four MAP kinase isoforms in human tissues. FEBS Lett 304:170-178
27. Gotoh Y, Nishida E, Shimanuki M, Toda T, Imai Y, Yamamoto M (1993) Schizosaccharomyces pombe SPK1 is a tyrosinephosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. Mol Cell Biol 13:6427-6434
28. Guex N (1996) Swiss-Pdb Viewer: A new fast and easy to use PDB viewer for the Macintosh. Experientia 52:A26
29. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 15:2760-2770
30. Han J, Lee JD, Bibbs L, Ulevitch RJ (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811
31. Han J, Richter B, Li Z, Kravchenko V, Ulevitch RJ (1995) Molecular cloning of human p38 MAP kinase. Biochim Biophys Acta 1265: 224-227
32. Hanks SK, Hunter T (1995) The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9:576-596
33. Hanks SK, Quinn AM, Hunter T (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52
34. Henikoff S, Henikoff JG (1992) Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA 89:10915-10919
35. Higgins DG, Thompson JD, Gibson TJ (1996) Using CLUSTAL for multiple sequence alignments. Methods Enzymol 266:383-402
36. Huttly AK, Phillips AL (1995) Gibberellin-regulated expression in oat aleurone cells of two kinases that show homology to MAP kinase and a ribosomal protein kinase. Plant Mol Biol 27:1043-1052
37. Jiang Y, Chen CH, Li ZJ, Guo W, Gegner JA, Lin SC, Han JH (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J Biol Chem 271:17920-17926
38. Jiang Y, Li ZJ, Schwarz EM, Lin AN, Guan KL, Ulevitch RJ, Han JH (1997) Structure-function studies of p38 mitogen-activated protein kinase: loop 12 influences substrate-specificity and autophosphorlation, but not upstream kinase selection. J Biol Chem 272:11096-11102
39. Johnson LN, Noble MEM, Owen DJ (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85:149-158
40. Jonak C, Pay A, Bogre L, Hirt H, Heberle-Bors E (1993) The plant homologue of MAP kinase is expressed in a cell cycle-dependent and organ-specific manner. Plant J 3:611-617
41. Jonak C, Kiegerl S, Ligterink W, Barker PJ, Huskisson NS, Hirt H (1996) Stress signaling in plants: a mitogen-activated protein kinase pathway is activated by cold and drought. Proc Natl Acad Sci USA 93:11274-11279
42. Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 8:2996-3007
43. Karin M (1996) The regulation of AP-1 activity by mitogen-activated protein kinases. Philos Trans R Soc Lond [Biol] 351:127-134
44. Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge
45. Krisak L, Strich R, Winters RS, Hall JP, Mallory MJ, Kreitzer D, Tuan RS, Winter E (1994) SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae, Genes Dev 8:2151-2161
46. Kültz D, Garcia-Perez A, Ferraris JD, Burg MB (1997) Distinct regulation of osmoprotective genes in yeast and mammals: aldose reductase osmotic response element is induced independent of p38 and SAPK/JNK in rabbit kidney cells. J Biol Chem 272:13165-13170
47. Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR (1997) Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 235:533-538
48. Kyriakis JM, Avruch J (1996) Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18:567-577
49. Lechner C, Zahalka MA, Giot JF, Moller NP, Ullrich A (1996) ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc Natl Acad Sci USA 93:4355-4359
50. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746
51. Lee JD, Ulevitch RJ, Han J (1995) Primary structure of BMK1: a new mammalian MAP kinase. Biochem Biophys Res Commun 213: 715-724
52. Li Z, Jiang Y, Ulevitch RJ, Han J (1996) The primary structure of p38γ: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun 228:334-340
53. 2 is phosphorylated and activated by MAP kinase. Cell 72: 269-278
54. LoGrasso PV, Frantz B, Rolando AM, O'Keefe SJ, Hermes JD, O'Neill EA (1997) Kinetic mechanism for p38 MAP kinase. Biochemistry 36:10422-10427
55. Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185
56. Mazzoni C, Zarov P, Rambourg A, Mann C (1993) The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae. J Cell Biol 123:1821-1833
57. Mewes HW, Albermann K, Bahr M, Frishman D, Gleissner A, Hani J, Heumann K, Kleine K, Maierl A, Oliver SG, Pfeiffer F, Zollner A (1997) Overview of the yeast genome. Nature 387:7-65
58. Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M (1994) c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 14:6683-6688
59. Mizoguchi T, Gotoh Y, Nishida E, Yamaguchi-Shinozaki K, Hayashida N, Iwasaki T, Kamada H, Shinozaki K (1994) Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells. Plant J 5:111-122
60. Mohit AA, Martin JH, Miller CA (1995) p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14:67-78
61. Navarro-Garcia F, Sanchez M, Pla J, Nombela C (1995) Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity. Mol Cell Biol 15:2197-2206.
62. Nishida E, Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128-131
63. Northwood IC, Gonzalez FA, Wartmann M, Raden DL, Davis RJ (1991) Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669. J Biol Chem 266:15266-15276
64. Ogiwara A, Uchiyama I, Takagi T, Kanehisa M (1996) Construction and analysis of a profile library characterizing groups of structurally known proteins. Prot Sci 5:1991-1999
65. Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD (1992) Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. Biochem Biophys Res Commun 182:1416-1422
66. Page RDM (1996) Treeview: an application to display phylogenetic trees on personal computers. CABIOS 12:357-358
67. Peitsch MC (1996) ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans 24: 274-279
68. Ray LB, Sturgill TW (1987) Rapid stimulation by insulin of a serine/ threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc Natl Acad Sci USA 84: 1502-1506
69. Rossomando AJ, Payne DM, Weber MJ, Sturgill TW (1989) Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc Natl Acad Sci USA 86:6940-6943
70. Saitou N, Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425
71. Seo S, Okamoto M, Seto H, Ishizuka K, Sano H, Ohashi Y (1995) Tobacco MAP kinase: a possible mediator in wound signal transduction pathways. Science 270:1988-1992
72. Sluss HK, Barrett T, Dérijard B, Davis RJ (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 14:8376-8384
73. Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997) p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem 272:19509-19517
74. Taylor SS, Radzio-Andzelm E (1994) Three protein kinase structures define a common motif. Structure 2:345-355
75. Tong L, Pav S, White DM, Rogers S, Crane KM, Cywin CL, Brown ML, Pargcllis CA (1997) A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nature Struct Biol 4:311-316
76. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205-215
77. Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z (1997) Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J Biol Chem 272: 23668-23674
78. Wang ZL, Harkins PC, Ulevitch RJ, Han JH, Cobb MH, Goldsmith EJ (1997) The structure of mitogen-activated protein kinase p38 at 2.1 Å resolution. Proc Natl Acad Sci USA 94:2327-2332
79. Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997) Mitogen-activated protein kinases activate the serine-threonine kinases MNK1 and MNK2. EMBO J 16:1909-1920
80. Wilson C, Heberlebors E, Vicente O (1997) A conserved motif at the carhoxy-terminus of MAP kinase. J Mol Evol 44:683-685
81. Wilson KP, Fitzgibbon MJ, Caron PN, Griffith JP, Chen WY, McCaffrey PG, Chambers SP, Su MSS (1996) Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem 271:27696-27700
82. Woodgett JR, Kyriakis JM, Avruch J, Zon LI, Zanke B, Templeton DJ (1996) Reconstitution of novel signalling cascades responding to cellular stresses. Philos Trans R Soc Lond [Biol] 351:135-141
83. Wurgler-Murphy SM, Saito H (1997) Two-component signal transducers and MAPK cascades. Trends Biochem Sci 22:172-176
84. Xu JR, Hamer JE (1996) MAP kinase and cAMP signaling regulate infection structure formation and pathogenic growth in the rice blast fungus Magnaporthe grisea. Genes Dev 10:2696-2706
85. Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL, Lee JC (1997) Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase hind in the ATP site. J Biol Chem 272:12116-12121
86. Zervos AS, Faccio L, Gatto JP, Kyriakis JM, Brent R (1995) Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc Natl Acad Sci USA 92:10531-10534
87. Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ (1994) Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution. Nature 367:704-711
88. Zhou G, Bao ZQ, Dixon JE (1995) Components of a new human protein kinase signal transduction pathway. J Biol Chem 270: 12665-12669
89. Zhu AX, Zhao Y, Moller DE, Flier JS (1994) Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. Mol Cell Biol 14:8202-8211