BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway

Cancer Research

Volumn 59, Issue 7 SUPPL., 1999, Pages

  Chen, Jun Jie ^a   Silver, Daniel ^a   Cantor, Sharon ^a   Livingston, David M ^a   Scully, Ralph ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GENE PRODUCT; MESSENGER RNA;

BREAST CANCER; CANCER SUSCEPTIBILITY; CELL CYCLE; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; FAMILIAL CANCER; FEMALE; HUMAN; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOMATIC CELL GENETICS; TISSUE SPECIFICITY;

EID: 0033119506     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (33)

1. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
2. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J. Collins, N., Gregory, S., Gumbs, C., Micklen, G., et al. Identification of the breast cancer susceptibility gene, BRCA2. Nature (Lond.), 378: 789-792, 1995.
3. Smith, S. A., Easton, D. F., Evans, D. G. R., and Ponder, B. A. J. Allele losses in the region 17q12-q21 in familial breast and ovarian cancer non-randomly involve the wild-type chromosome Nat. Genet., 2: 128-131, 1992.
4. Neuhausen, S. L., and Marshall, C. J. Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res., 54: 6069-6072, 1994.
5. Shattuck-Eidens, D., McClure, M., Simard, J., Labrie, F., Narod, S., Couch, F., Hoskins, K., Weber, B., Castilla, L., Erdos, M., Brody, L., Friedman, L., Ostermeyer, E., Szabo, C., King, M-C., Jhanwar, S., Offit, K., Norton, L., Gilewski, T., Lubin, M., Osborne, M., Black, D., Boyd, M., and Steel, M. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. J. Am. Med. Assoc., 273: 535-541, 1995.
6. Friedman, L. S., Ostermeyer, E. A., Szabo, C. I., Dowd, P., Lynch, E. D., Rowell, S. E., and King, M-C. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat. Genet., 8: 399-404, 1994.
7. Koonin, V. F., Altschul, S. F., and Bork, P. BRCA1 protein products: functional motifs. Nat. Genet., 13: 266-267, 1996.
8. Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., and Koonin, E. V. A superfamily of conserved domains in DNA damage-responsive cell cycle check-point proteins. FASEB J., 11: 68-76, 1997.
9. Callebaut, I., and Mornon, J. P. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett., 400: 25-30, 1997.
10. Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M. C., Hwang, L. Y., Bowcock, A. M., and Baer, R. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet., 14: 430-40, 1996.
11. Chapman, M. S., and Verma, I. M. Transcriptional activation by BRCA1. Nature (Lond.), 382: 678-679, 1996.
12. Monteiro, A. N. A., August, A., and Hanafusa, H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA, 93: 13595-13599, 1996.
13. Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., and Parvin, J. D. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA, 94: 5605-5610, 1997.
14. Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H., Drapkin, R., Rickert, P., Lees, E., Anderson, C. W., Linn, S., and Reinberg, D. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature (Lond.), 381: 86-89, 1996.
15. Lane, T. F., Deng, C., Elson, A., Lyu, M. S., Kozak, C. A., and Leder, P. Expression of BRCA1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev., 9: 2712-2722, 1995.
16. Marquis, S. T., Rajan, J. V., Wynshaw-Boris, A., Xu, J., and Yin, G-Y. The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues. Nat. Genet., 11: 17-26, 1995.
17. Gudas, J. M., Li, T., Nguyen, H., Jensen, D., Rauscher, F. J. I., and Cowan, K. H. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ., 7: 717-723, 1996.
18. Hakem, R., de la Pomba, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., Firpo, E., Hui, C. C., Roberts, J., Rossant, J., and Mak, T. W. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell, 85: 1009-1023, 1996.
19. Liu, C. Y., Flesken-Nikitin, A., Li, S., Zeng, Y., and Lee, W-H. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev., 10: 1835-1843, 1996.
20. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. M. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.
21. Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D. M. Dynamic Changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell, 90: 425-435, 1997.
22. Scully, R., Ganesan, S., Brown, M., De Caprio, J. A., Cannistra, S. A., Feunteun, J., Schnitt, S., and Livingston, D. M. Location of BRCA1 in human breast and ovarian cell lines. Science (Washington DC), 272: 123-125, 1996.
23. Radding, C. M. Helical interactions in homologous pairing and strand exchange driven by RecA protein. J. Biol. Chem., 266: 5355-5358, 1991.
24. Sung, P. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein. Science (Washington DC), 265: 1241-1243, 1994.
25. Baumann, P., Benson, F. E., and West, S. C. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell, 87: 757-766, 1996.
26. Shinohara, A., Ogawa, H., and Ogawa, T. Rad51 protein involved in repair and recombination in Saccharomyces cerevisiae is a RecA-like protein. Cell, 69: 457-470, 1992.
27. Lim, D-S., and Hasty, P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a p53 mutation. Mol. Cell. Biol., 16: 7133-7143, 1996.
28. Chen, Y. M., Farmer, A. A., Chen, C. F., Jones, D. C., Chen, P. L., and Lee, W. H. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res., 56: 3168-3172, 1996.
29. Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A., Itie, A., Koo, W., Billia, P., Ho, A., Fukumoto, M., Hui, C. C., and Mak, T. W. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev., 11: 1242-1252, 1997.
30. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D-S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., and Bradley, A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking BRCA2. Nature (Lond.), 386: 804-810, 1997.
31. Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., and Scully, R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells Mol. Cell., 2: 317-328, 1998.
32. Friedberg, E. C., Walker, G. C., and Siede, W. (eds.). DNA Repair and Mutagenesis. Washington, D.C.: ASM Press, 1995.
33. Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A., and Venkitaraman, A. R. Involvement of Brca2 in DNA repair. Mol. Cell, 1: 347-357, 1998.