Animal Nutrition and Metabolism Group Symposium on 'Fatty acids, forages and food quality': Conjugated linoleic acid and its effects on animal products and health in single-stomached animals

Proceedings of the Nutrition Society

Volumn 62, Issue 2, 2003, Pages 319-328

  Azain, Michael J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Animal health; Animal products; Conjugated linoleic acid; Single stomached animals

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; ICOSANOID; LINOLEIC ACID; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; CONJUGATED LINOLEIC ACID; IMMUNOLOGICAL ADJUVANT;

ANIMAL HEALTH; ANIMAL PRODUCT; ANTIBIOTIC THERAPY; CIS TRANS ISOMERISM; CONFERENCE PAPER; CYTOKINE PRODUCTION; DIETARY INTAKE; FOOD QUALITY; FORAGE; GENE EXPRESSION; IMMUNOMODULATION; LIVESTOCK; METABOLISM; NONHUMAN; NUTRITIONAL STATUS; OBESITY; RODENT; SPECIES DIFFERENCE; SWINE; VACCINATION; ADIPOSE TISSUE; ANIMAL; ANIMAL FOOD; ANIMAL WELFARE; CHEMISTRY; FISH; HUMAN; ISOMERISM; PHYSIOLOGY; POULTRY; REVIEW;

ANIMALIA; RODENTIA; SUS SCROFA;

ADIPOSE TISSUE; ADJUVANTS, IMMUNOLOGIC; ANIMAL FEED; ANIMAL NUTRITION PHYSIOLOGY; ANIMAL WELFARE; ANIMALS; ANTI-OBESITY AGENTS; ANTINEOPLASTIC AGENTS; FISHES; HUMANS; ISOMERISM; LINOLEIC ACIDS, CONJUGATED; POULTRY; SPECIES SPECIFICITY; SWINE;

EID: 1542751690     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2003240     Document Type: Conference Paper

References (85)

1. Averette-Gatlin L, See MT, Larick DK, Lin X & Odle J (2002) Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. Journal of Nutrition 32, 3105-3112.
2. Aydin R, Pariza MW & Cook ME (2001) Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. Journal of Nutrition 131, 800-806.
3. Azain MJ & Chi F (2001) The anti-obesity effects of conjugated linoleic acid in the rat are accounted for by the trans-10, cis-12 isomer, but are gender dependent. Proceedings of the Nutrition Society 60, 214A.
4. Azain MJ, Hausman DB, Sisk MB, Flatt WP & Jewell DE (2000) Dietary conjugated linoleic acid reduces rat adipose tissue cell size. Journal of Nutrition 130, 1548-1554.
5. Bartlett JC & Chapman DG (1961) Detection of hydrogenated fats in butter by measurement of cis-trans conjugated unsaturation. Journal of Agricultural and Food Chemistry 9, 50-53.
6. Bassaganya-Riera J, Hontecillas-Margarzo R, Bregendahl K, Wannemuehler MJ & Zimmerman DR (2001) Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition and immune competence. Journal of Animal Science 79, 714-721.
7. Baumgard LH, Sangster JK & Bauman DE (2001) Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). Journal of Nutrition 131, 1764-1769.
8. Bee G (2000) Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. Journal of Nutrition 130, 2981-2989.
9. Bee G (2001) Dietary conjugated linoleic acids affect tissue lipid composition but not de novo lipogenesis in finishing pigs. Animal Research 50, 383-389.
10. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J & Gudmundsen O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Journal of Nutrition 130, 2943-2948.
11. Brodie AE, Manning VA, Ferguson KR, Jewell DE & Hu CY (1999) Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. Journal of Nutrition 129, 602-606.
12. Bulgarella JA, Patton D & Bull AW (2001) Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers. Lipids 36, 407-412.
13. Chamruspollert M & Sell J (1999) Transfer of dietary conjugated linoleic acid to egg yolks of chickens. Poultry Science 78, 1138-1150.
14. Chin SF, Lui W, Storkson JM, Ha YL & Pariza MW (1992) Dietary sources of conjugated diene isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis 5, 185-197.
15. Chin SF, Storkson JM, Albright KJ, Cook ME & Pariza MW (1994a) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. Journal of Nutrition 124, 2344-2349.
16. Chin SF, Storkson JM, Liu W, Albright KJ & Pariza MW (1994b) Conjugated linoleic acid (9, 11- and 10, 12-octadecanoic acid) is produced in conventional but not germ-free rats fed linoleic acid. Journal of Nutrition 124, 694-701.
17. Cook ME, Miller CC, Park Y & Pariza M (1993) Immune modulation by altered nutrient metabolism: Nutritional control of immune-induced growth depression. Poultry Science 72, 1301-1305.
18. 9-desaturase in the production of cis-9, trans-11 CLA. Journal of Nutritional Biochemistry 12, 622-630.
19. DeLany JP, Blohm F, Truett AA, Scimeca JA & West DB (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. American Journal of Physiology 276, R1172-R1179.
20. Du M & Ahn DU (2002) Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. Poultry Science 81, 428-433.
21. Dugan MER, Aalus JL, Lien KA, Schaefer AL & Kramer JKG (1997) The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Canadian Journal of Animal Science 77, 723-725.
22. Dugan MER, Aalus JL, Lien KA, Schaefer AL & Kramer JKG (2001) Effects of feeding different levels of conjugated linoleic acid and total oil to pigs on live animal performance and carcass composition. Canadian Journal of Animal Science 81, 505-510.
23. Eggert JM, Belury MA, Kempa-Steczko A, Mills SE & Schinkel AP (2001) Effects of conjugated linoleic acid on the belly firmness and fatty acid composition of genetically lean pigs. Journal of Animal Science 79, 2866-2872.
24. Glaser KR, Scheeder MRL & Wenk C (2000) Dietary C18:1 trans fatty acids increase conjugated linoleic acid in adipose tissue of pigs. European Journal of Lipid Science and Technology 102, 684-686.
25. Ha YL, Grimm NK & Pariza MW (1989) Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed chesses. Journal of Agricultural and Food Chemistry 37, 75-81.
26. Hayek MG, Han SN, Wu D, Watkins BA, Meydani M, Dorsey JL, Smith DE & Meydani SN (1999) Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCr1BR mice. Journal of Nutrition 129, 32-38.
27. Hjartaker A, Laake P & Lund E (2001) Childhood and adult milk consumption and risk of premenopausal breast cancer in a cohort of 48,884 women - The Norwegian women and cancer study. International Journal of Cancer 93, 888-893.
28. Ip C, Banni S, Angioni E, Carta G, McGinley J, Thompson HJ, Barbano D & Bauman D (1999) Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. Journal of Nutrition 129, 2135-2142.
29. Ip C, Dong Y, lp MM, Banni S, Carta G, Angioni E, Murru E, Spada S, Melis MP & Saebo A (2002) Conjugated linoleic acid isomers and mammary cancer prevention. Nutrition and Cancer 43, 52-58.
30. Ip C, Scimeca JA & Thompson HJ (1994) Conjugated linoleic acid: A powerful anticarcinogen from animal sources. Cancer 74, Suppl., 1050-1054.
31. Jahreis G, Fritsche J, Mockel P, Schone F & Moller U (1999) The potential anticarcinogenic, conjugated cis-9, trans-11 C18:2, in milk of different species: cow, goat, ewe, sow, mare, woman. Nutrition Research 19, 1541-1549.
32. Jarvinen R, Knect P, Seppanen R & Teppo L (1997) Diet and breast cancer risk in a cohort of Finnish women. Cancer Letters 114, 251-253.
33. Kamlage B, Hartmann L, Gruhl B & Blaut M (1999) Intestinal microorganisms do not supply associated gnotobiotic rats with conjugated linoleic acid. Journal of Nutrition 129, 2212-2217.
34. Kelly DS, Taylor PC, Rudolph IL, Benito P, Nelson GJ, Mackey BE & Erickson KL (2000) Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids 35, 1065-1071.
35. Kepler CR, Hirons HP, McNeill JJ & Tove SB (1966) Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio flibrisolvens. Journal of Biological Chemistry 242, 3612-3620.
36. Kritchevsky D (2000) Antimutagenic and some other effects of conjugated linoleic acid. British Journal of Nutrition 83, 459-465.
37. Leskanich CO, Matthews KR, Warkup CC, Noble RC & Hazzledine M (1997) The effect of dietary oil containing (n-3) fatty acids on the fatty acid, physiochemical, and organoleptic characteristics of pig meat and fat. Journal of Animal Science 75, 673.
38. Lin H, Boylston TD, Chang MJ, Luedecke LO & Shultz TD (1995) Survey of the conjugated linoleic acid contents of dairy products. Journal of Dairy Science 78, 2358-2365.
39. Masters N, McGuire MA, Beerman KA, Dasgupta N & McGuire MK (2002) Maternal supplementation with CLA decreases milk fat in humans. Lipids 37, 133-138.
40. Miller CC, Park Y, Pariza MW & Cook ME (1994) Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochemical and Biophysical Research Communications 198, 1107-1112.
41. Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, Tsigilis N & Nikolaidis M (2001) Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. Journal of Nutritional Biochemistry 12, 585-594.
42. Moya-Camarena, SY & Belury MA (1999) Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid. Nutrition Reviews 57, 336-340.
43. Muller HL, Stangl GI & Kirchessner M (1998) Energy balance of conjugated linoleic acid treated pigs. Journal of Animal Physiology and Animal Nutrition 81, 150-156.
44. National Cattlemans' Beef Association (2002) National Cattlemans' Beef Association. CBB/NCBA Human Nutrition Research Program. http://www.beefnutrition.org/research/
45. National Dairy Council (2002) National Dairy Council web site. http://www.nationaldairycouncil.org/
46. O'Quinn PR, Andrews BS, Goodband RD, Unruh JA, Nelssen, JL, Woodworth JC, Tokach MD & Owen KQ (2000b) Effects of modified tall oil and creatine monohydrate on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. Journal of Animal Science 78, 2376-2382.
47. O'Quinn PR, Nelssen, JL, Goodband RD, Unruh JA, Woodworth JC, Smith JS & Tokach MD (2000a) Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs. Journal of Animal Science 78, 2359-2368.
48. Ostrowska E, Muralitharan M, Cross RF, Bauman DE & Dunshea FR (1999) Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. Journal of Nutrition 129, 2037-2042.
49. Overland M, Taugbol O, Haug A & Sundstol E (1996) Effect of fish-oil on growth performance, carcass characteristics, sensory parameters, and fatty acid composition in pigs. Acta Agriculturae Scandinavica 46, 11-17.
50. Palombo JD, Ganguly A, Bistrian BR & Menard MP (2002) The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Letters 177, 163-172.
51. Pariza MW, Park Y & Cook ME (2001) The biologically active isomers of conjugated linoleic acid. Progress in Lipid Research 40, 283-298.
52. Park HS, Ryu JH, Ha YL & Park JHY (2001) Dietary conjugated linoleic acid induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: a possible mechanism for the anticarcinogenic effect of CLA. British Journal of Nutrition 86, 549-555.
53. Park Y, Albright KL, Liu W, Storkson JM, Cook ME & Pariza MW (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32, 853-858.
54. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME & Pariza MW (1999a) Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34, 243-248.
55. Park Y & Pariza MW (2001) Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochimica et Biophysica Acta 1534, 27-33.
56. Park Y, Storkson JM, Albright KJ, Liu W & Pariza MW (1999b) Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34, 235-241.
57. Poulos SP, Azain MJ & Hausman GJ (2000) In utero dietary conjugated linoleic acid alters body composition and growth rate in newborn pigs. Journal of Animal Science 78, Suppl. 1, 136.
58. Poulos SP, Sisk M, Hausman DB, Azain MJ & Hausman GJ (2001) Pre- and post-natal dietary conjugated linoleic acid (CLA) alters adipose tissue development, body weight gain and body composition in Sprague-Dawley rats. Journal of Nutrition 131, 2722-2731.
59. Ramsay TG, Evock-Clover CM, Steele NC & Azain MJ (2001) Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. Journal of Animal Science 79, 2152-2161.
60. Riserus U, Berglund L & Vessby B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle aged men with signs of the metabolic syndrome, A randomized controlled trial. International Journal of Obesity 25, 1129-1135.
61. Roche HM, Noone E, Nugent A & Gibney MJ (2001) Conjugated linoleic acid, a novel therapeutic nutrient? Nutrition Research Reviews 14, 173-187.
62. Santora JE, Palmquist DL & Roehrig KL (2000) Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. Journal of Nutrition 130, 208-215.
63. Satory D & Smith SB (1999) Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. Journal of Nutrition 129, 92-97.
64. Scollan ND, Dhanoa MS, Choi NJ, Maeng WJ, Enser M & Wood JD (2001) Biohydrogenation and digestion of long chain fatty acids in steers fed on different sources of lipid. Journal of Agricultural Science, Cambridge 136, 345-355.
65. Sisk M, Hausman DB, Martin RJ & Azain MJ (2001) Dietary conjugated linoleic acid reduces adiposity in lean, but not obese Zucker rats. Journal of Nutrition 131, 1668-1674.
66. Sugano M, Tsujita A, Yamasaki M, Noguchi M & Yamada K (1998) Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 33, 521-527.
67. Szymczyk B, Pisulewski PM, Szczurek W & Hanczakowski P (2001) Effects of conjugated linoleic acid on growth performance, feed conversion efficiency and subsequent carcass quality in broiler chickens. British Journal of Nutrition 85, 465-473.
68. Takahashi K, Kawamata K, Akiba Y, Iwata T & Kasai M (2002) Influence of dietary conjugated linoleic acid isomers on early inflammatory responses in male broiler chickens. British Poultry Science 43, 47-53.
69. Taugbol O (1993) Omega-3 fatty acid incorporation in fat and muscle tissues of growing pigs fed supplements of fish oil. Journal of Veterinary Medicine 40, 93-101.
70. Terpstra AHM (2001) Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: Role of metabolic rate. Journal of Nutrition 131, 2067-2068.
71. Terpstra AHM, Beynen AC, Everts H, Kocsis S, Katan MB & Zock PL (2002) The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in excreta. Journal of Nutrition 132, 940-945.
72. Thiel-Cooper RL, Farrish FC, Sparks JC, Wigand BR & Ewan RC (2001) Conjugated linoleic acid changes swine performance and carcass composition. Journal of Animal Science 79, 1821-1828.
73. Thom E, Wadstein J & Gudmundsen O (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. Journal of International Medical Research 29, 392-396.
74. Tischendorf F, Schone F, Kirchheim U & Jarhreis G (2002) Influence of a conjugated linoleic acid mixture on growth, organ weights, carcass traits and meat quality in growing pigs. Journal of Animal Physiology and Animal Nutrition 86, 117-128.
75. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim H-J, Tange T, Okuyama H, Kasai M, Ikemoto S & Ezaki O (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 1534-1542.
76. Turek JJ, Li Y, Schoenlein IA, Allen KGD & Watkins BA (1998) Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio. Journal of Nutritional Biochemistry 9, 258-266.
77. Twibell RG, Watkins BA & Brown PB (2001) Dietary conjugated linoleic acids and lipid source alter fatty acid composition of juvenile yellow perch, Perca falvescens. Journal of Nutrition 131, 2322-2328.
78. Twibell RG, Watkins BA, Rogers L & Brown PB (2000) Effects of conjugated linoleic acids on hepatic and muscle lipids in hybrid striped bass. Lipids 35, 155-161.
79. Waylan AT, O'Quinn PR, Unruh JA, Nelssen JL, Goodband RD, Woodworth JC, Tocah MD & Koo SI (2002) Effects of modified tall oil and vitamin E on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. Journal of Animal Science 80, 1575-1585.
80. Weber TE, Schinkel AP, Housekneckt KL & Richert BT (2001) Evaluation of conjugated linoleic acid and dietary antibiotics as growth promotants in weanling pigs. Journal of Animal Science 79, 2542-2549.
81. West DB, Delany JP, Camet PM, Blohm F, Truet AA & Scimeca J (1998) Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. American Journal of Physiology 275, R667-R672.
82. Whigham LD, Cook ME & Atkinson RL (2000) Conjugated linoleic acid: Implications for human health. Pharmacological Research 42, 503-510.
83. Whigham LD, Higbee A, Bjorling DE, Park Y, Pariza MW & Cook ME (2002) Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. American Journal of Physiology 282, R1104-R1112.
84. Wiegand BR, Sparks JC, Parrish FC & Zimmerman DR (2002) Duration of feeding conjugated linoleic acid influences growth performance, carcass traits, and meat quality of finishing barrows. Journal of Animal Science 80, 637-643.
85. Zambell KL, Klein NL, Van Loan MD, Gale B, Benito P, Kelley DS & Nelson GJ (2000) Conjugated linoleic acid supplementation in humans: Effects on body composition and energy expenditure. Lipids 35, 777-782.