Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes

Journal of Nutrition

Volumn 129, Issue 1, 1999, Pages 92-97

  Satory, David L ^a   Smith, Stephen B ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

CLA; Differentiation; Mice; Obesity; Preadipocyte; Proliferation

Indexed keywords

ARACHIDONIC ACID; CONJUGATED LINOLEIC ACID; DNA; FATTY ACID; FATTY ACID DERIVATIVE; GLUCOSE; GLUTAMINE; LINOLEIC ACID; LIPID; PALMITIC ACID; PALMITOLEIC ACID; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; CULTURE MEDIUM; FETAL CALF SERUM; GROWTH INHIBITION; LIPOGENESIS; MOUSE; NONHUMAN; PROADIPOCYTE;

ANIMALIA; BOVINAE; CICONIIFORMES; MURINAE; TRITIUM;

EID: 0032901114     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.1.92     Document Type: Article

References (34)

1. Belury, M. A. & Kempa-Steczko, A. (1997) Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32: 199-204.
2. Belury, M. A., Locniskar, M. F. & Fischer, S. M. (1993) Modulation of phorbol ester associated events in cultured epidermal cells by linoleate and arachidonate. Lipids 28: 407-413.
3. Belury, M. A., Nickel, K., Bird, C. & Wu, Y. (1996) Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. Nutr. Cancer 26: 149-157.
4. Cesano, A., Visonneau, S., Scimeca, J. A., Kritchevshy, D. & Santoli, D. (1998) Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res. 18: 1429-1434.
5. Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L. & Pariza, M. (1992) Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J. Food Comp. Anal. 5: 185-197.
6. Chin, S. F., Storkson, J. & Pariza, M. (1993) Conjugated dienoic derivatives of linoleic acid, a new class of food derived anticarcinogens. J. Agric. Food Chem. 528: 262-271.
7. Christy, R. J., Kaestner, K. H., Geiman, D. E. & Lane, M. D. (1991) CCAAT/enhancer binding protein gene promoter binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Dev. Biol. 88: 2593-2597.
8. Christy, R. J., Yang, V. W., Ntambi, J. M., Geiman, D., Landschulz, W., Freidman, A. D., Nakabeppul, Y., Kelly, T. & Lane, M. D. (1989) Differentiation induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte specific genes. Genes Dev. 3: 1323-1335.
9. Cunningham, D., Harrison, L. & Schultz, T. (1997) Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. Anticancer Res. 17: 197-204.
10. Folch, J., Lees, M. & Sloane-Stanley, G. H. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509
11. Gurr, I. G. (1987) Isomeric fatty acids. Biochem. Soc. Trans. 15: 336-339.
12. Ha, Y., Grimm, N. & Pariza, M. (1989) Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J. Agric. Food Chem. 37: 75-78.
13. Ha, Y., Storkson, J. & Pariza, M. (1990) Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res. 50: 1097-1101.
14. Huang, Y. C., Leudecke, L. O. & Schultz, T. D. (1994) Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men. Nutr. Res. 14: 373-386.
15. Ip, C. (1997) Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. Am. J. Clin. Nutr. 66: 1523S-1529S.
16. Ip, C., Chin, S. F., Scimeca, J. & Pariza, M. (1991) Mammary cancer prevention by conjugated dienoic derivatives of linoleic acid. Cancer Res. 51: 6118-6124.
17. Kepler, C. R. & Tove, S. B. (1967) Biohydrogenation of unsaturated fatty acids. J. Biol. Chem. 242: 5686-5696.
18. Koohmaraie, M. (1987) The relationship between cell proliferation and phosphatidylinositol metabolism in skeletal muscle cells in culture. J. Anim. Sci. 64: 633-638.
19. Kramer, J. K., Sehat, N., Dugan, M. E., Mossoba, M. M., Yurawecz, M. P., Roach, J. A., Eulitz, K., Aalhus, J. L., Schaefer, A. L. & Ku, Y. (1998) Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatography. Lipids 33: 549-558.
20. 2 synthesis in murine keratinocytes. Cancer Lett. 127: 15-22.
21. Mandrup, S. & Lane, M. D. (1997) Regulating adipogenesis. J. Biol. Chem. 272: 5367-5370.
22. May, S. G., Savell, J. W., Lunt, D. K., Wilson, J. J., Laurenz, J. C. & Smith, S. B. (1994) Evidence for preadipocyte proliferation during culture of subcutaneous and intramuscular adipose tissues from Angus and Wagyu crossbred steers. J. Anim. Sci. 72: 3110-3117.
23. Morrison, W. R. & Smith, L. M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron flouride-methanol. J. Lipid Res. 5: 600-608.
24. 2α is a potent inhibitor of 3T3-L1 preadipocyte differentiation. FASEB J. 12: A515 (abs.).
25. Pariza, M., Ha, Y. L., Benjamin, H., Sword, J. T., Gruter, A., Chin, S. F., Storkson, J., Faith, N. & Albright, K. (1991) Formation and action of anticarcinogenic fatty acids. In: Nutritional and Toxicological Consequences of Food Processing (Friedman, M., ed.), pp. 269-272. Plenum Press, New York, NY.
26. Pariza, M., Park, Y., Cook, M., Albright, K. & Liu, W. (1996) Conjugated linoleic acid reduces body fat. FASEB J. 10: A560 (abs.).
27. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E. & Pariza, M. W. (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32: 853-858.
28. Schultz, T. D., Chew, B. P. & Seaman, W. R. (1992) Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res. 12: 2143-2146.
29. Sebedio, J. L. (1997) Conjugated linoleic acid metabolites in rat. Biochim. Biophys. Acta 1345: 35-42.
30. Sisk, M., Azain, M. J. & Hausman, D. B. (1998) Effect of conjugated linoleic acid on fat pad weights and cellularity in Sprague-Dawley and Zucker rats. FASEB J. 12: A536 (abs.).
31. Strutt, B., Khalil, W. & Killinger, D. (1996) Growth and differentiation of human adipose stromal cells in culture. In: Methods in Molecular Medicine: Cell Culture Protocols (Jones, G. E., ed.), pp. 41-51. Humana Press, Totowa, NJ.
32. Student, A. K., Hsu, R. Y. & Lane, M. D. (1980) Induction of fatty acid synthase synthesis in differentiating 3T3-L1 preadipocytes. J. Biol. Chem. 255: 4745-4750.
33. Umek, R., Freidman, A. & McKnight, S. (1990) CCAAT-enhancer binding protein: a component of a differentiation switch. Science (Washington, DC) 251:288-292.
34. Viviani, R. (1970) Metabolism of long-chain fatty acids in the rumen. Adv. Lipid Res. 8: 267-274.