Conjugated linoleic acid: A novel therapeutic nutrient?

Nutrition Research Reviews

Volumn 14, Issue 1, 2001, Pages 173-187

  Roche, H M ^a   Noone, E ^a   Nugent, A ^a   Gibney, M J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

Author keywords

Conjugated linoleic acid; Coronary heart disease; Lipid metabolism

Indexed keywords

CHOLESTEROL; CYTOKINE; ICOSANOID; LINOLEIC ACID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ATHEROGENESIS; ATHEROSCLEROSIS; BODY COMPOSITION; CARCINOGENESIS; CELLULAR IMMUNITY; CHOLESTEROL BLOOD LEVEL; CHRONIC INFLAMMATION; CONJUGATION; CYTOKINE PRODUCTION; FAT INTAKE; GENETIC TRANSCRIPTION; HUMAN; ICOSANOID METABOLISM; INFLAMMATION; ISCHEMIC HEART DISEASE; ISOMER; LEAN BODY WEIGHT; LIPOPROTEIN METABOLISM; NONHUMAN; OBESITY; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA;

EID: 0034972713     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/095442201108729187     Document Type: Review

References (66)

1. Biosynthesis of conjugated linoleic acid in humans
2. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number
3. Conjugated linoleic acid induces lipid peroxidation in humans
4. Dietary conjugated linoleic acid induces peroxisone-specific enzyme accumulation and omithine decarboxylase activity in mouse liver
5. Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells
6. Distribution of Butyrivibrio fibrisolvens in nature
7. Experimental cancer cachexia: The role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 B1 background and eicosanoid-dependent cachexia
8. Effect of conjugated dieonic derivatives of linoleic acid and β-carotene in modulating lymphocyte and macrophage function
9. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognised class of anti-carcinogenesis
10. The trans- 10, cis- 12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes
11. Effects of different conjugated linoleic acid isomers on lipid variables in hamsters
12. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake
13. Peroxisome proliferator-activated receptor-alpha receptors regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
14. An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters
15. Trans-octadecenoic acids and mild fat depression in lactating dairy cows
16. Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR Mice
17. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans
18. The role of TNFalpha and TNF receptors in obesity and insulin resistance
19. Dietary conjugated linoleic acid normalises impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat
20. Effect of cheddar cheese consumption on the plasma conjugated linoleic acid concentration in men
21. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
22. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue
23. Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens
24. Roles of PPARs in health and disease
25. Structure and function of the uncoupling proteins from brown adipose tissue
26. Antimutagenic and some other effects of conjugated linoleic acid
27. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits
28. Conjugated linoleic acid and atherosclerosis in rabbits
29. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression
30. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
31. Survey of the conjugated linoleic acid contents of dairy products
32. PPARgamma: An essential regulator of adipogenesis and modulator of fat cell function
33. Conjugated linoleic acid and disease prevention: A review of current knowledge
34. Conjugated linoleic acid concentration of human milk and infant formula
35. The transcription factor NF-kappaB: Control of oncogenesis and cancer therapy resistance
36. Cytokine regulation of cellular adhesion molecule expression in inflammation
37. Conjugated linoleic acid supplementation in humans: Effects on circulating leptin concentrations and appetite
38. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection
39. Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid
40. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
41. Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model
42. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolaemic hamsters
43. Accumulation of LDL in rat arteries is associated with activation of tumor necrosis factor-alpha expression
44. Conjugated linoleic acid - The effect of supplementation on plasma lipid metabolism
45. The effect of conjugated linoleic acid on the inflammatory response in humans
46. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
47. Conjugated linoleic acid and the control of cancer and obesity
48. Effect of conjugated linoleic acid on body composition in mice
49. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice
50. High-fat dairy product consumption increases Δ9c, 11t-18:2 (rumenic acid) and total lipid concentrations of human milk
51. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives
52. The impact of postprandial lipaemia in accelerating atherothrombosis
53. Serum soluble tumor necrosis factor-alpha receptor 2 is elevated in obesity but is not related to insulin sensitivity: A study in identical twins discordant for obesity
54. Dietary trans fatty acids increase conjugated linoleic acid levels in human serum
55. Metabolites of conjugated isomers of linoleic acid (CLA) in the rat
56. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not PPARγ activators
57. A prospective Study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction
58. A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
59. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidised LDL
60. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice
61. Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio
62. Peroxisome proliferator-activated receptor - A critical link among fatty acids, gene expression and carcinogenesis
63. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse
64. Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice
65. 10 trans, 12 cis-linoleic acid reduces apolipoprotein B secretion in HepG2 cells
66. Conjugated linoleic acid supplementation in humans: Effects on body composition and energy expenditure