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Volumn 4, Issue 2, 2004, Pages 169-188

Breast cancer biomarkers and molecular medicine: Part II

Author keywords

Biomarkers; Breast cancer; ER; Heat shock proteins; Matrix metalloproteases; MDR; Microarrays; Oncogenes; P53; Pharmacogenetics; Pharmacogenomics; Plasminogen; PR proteases; Prognosis; Telomerase; Transcriptional profiling; Tumor suppressor genes

Indexed keywords

AMONAFIDE; ANASTROZOLE; ANTHRACYCLINE; AROMATASE INHIBITOR; AZACITIDINE; BEVACIZUMAB; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; CETUXIMAB; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ERLOTINIB; EXEMESTANE; FLAVOPIRIDOL; FLUOROURACIL; GEFITINIB; IRINOTECAN; LETROZOLE; MARIMASTAT; MATRIX METALLOPROTEINASE; MERCAPTOPURINE; MULTIDRUG RESISTANCE PROTEIN 1; OBLIMERSEN; PACLITAXEL; PROTEASOME INHIBITOR; TAMOXIFEN; TRASTUZUMAB;

EID: 1542358118     PISSN: 14737159     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737159.4.2.169     Document Type: Review
Times cited : (45)

References (236)
  • 1
  • 2
    • 0034538306 scopus 로고    scopus 로고
    • C-myc amplification in breast cancer: A meta-analysis of its occurrence and prognostic relevance
    • Deming SL, Nass SJ, Dickson RB et al. C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance. Br. J. Cancer 83, 1688-1695 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 1688-1695
    • Deming, S.L.1    Nass, S.J.2    Dickson, R.B.3
  • 3
    • 0029555045 scopus 로고
    • N-myc protein expression in human breast carcinoma: Prognostic implications
    • Mizukami Y, Nonomura A, Takizawa T et al. N-myc protein expression in human breast carcinoma: prognostic implications. Anticancer Res. 15, 2899-2905 (1995).
    • (1995) Anticancer Res. , vol.15 , pp. 2899-2905
    • Mizukami, Y.1    Nonomura, A.2    Takizawa, T.3
  • 4
    • 0038024096 scopus 로고    scopus 로고
    • C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer
    • Schlotter CM, Vogt U, Bosse U et al. C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer. Breast Cancer Res. 5, R30-R36 (2003).
    • (2003) Breast Cancer Res. , vol.5
    • Schlotter, C.M.1    Vogt, U.2    Bosse, U.3
  • 5
    • 0024501187 scopus 로고
    • Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer
    • Rochlitz CF, Scott GK, Dodson JM et al. Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer. Cancer Res. 49, 357-360 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 357-360
    • Rochlitz, C.F.1    Scott, G.K.2    Dodson, J.M.3
  • 6
    • 0033190671 scopus 로고    scopus 로고
    • H-ras gene amplification or mutation is not common in human primary breast cancer
    • Schondorf T, Andrack A, Niederacher D et al. H-ras gene amplification or mutation is not common in human primary breast cancer. Oncol. Rep. 6, 1029-1033 (1999).
    • (1999) Oncol. Rep. , vol.6 , pp. 1029-1033
    • Schondorf, T.1    Andrack, A.2    Niederacher, D.3
  • 7
    • 0029054770 scopus 로고
    • Oncogene protein coexpression. Value of H-ras, c-myc, c-fos and p53 as prognostic discriminants for breast carcinoma
    • Bland KI, Konstadoulakis MM, Vezeridis MP et al. Oncogene protein coexpression. Value of H-ras, c-myc, c-fos and p53 as prognostic discriminants for breast carcinoma. Ann. Surg. 221, 706-720 (1995).
    • (1995) Ann. Surg. , vol.221 , pp. 706-720
    • Bland, K.I.1    Konstadoulakis, M.M.2    Vezeridis, M.P.3
  • 8
    • 0025174653 scopus 로고
    • Strong association between c-myb and estrogen-receptor expression in human breast cancer
    • Guerin M, Sheng ZM, Andrieu N et al. Strong association between c-myb and estrogen-receptor expression in human breast cancer. Oncogene 5, 131-135 (1990).
    • (1990) Oncogene , vol.5 , pp. 131-135
    • Guerin, M.1    Sheng, Z.M.2    Andrieu, N.3
  • 9
    • 0029094872 scopus 로고
    • Immunocytochemical localization of Fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy
    • Gee JM, Ellis IO, Robertson JF et al. Immunocytochemical localization of Fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy, Int. J. Cancer 64, 269-273 (1995).
    • (1995) Int. J. Cancer , vol.64 , pp. 269-273
    • Gee, J.M.1    Ellis, I.O.2    Robertson, J.F.3
  • 10
    • 0344629812 scopus 로고    scopus 로고
    • Jun activation domain binding protein 1 expression is associated with low p27(Kip1) levels in node-negative breast cancer
    • Esteva FJ, Sahin AA, Rassidakis GZ et al. Jun activation domain binding protein 1 expression is associated with low p27(Kip1) levels in node-negative breast cancer. Clin. Cancer Res. 9, 5652-5659 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5652-5659
    • Esteva, F.J.1    Sahin, A.A.2    Rassidakis, G.Z.3
  • 11
    • 0034688957 scopus 로고    scopus 로고
    • Biological and clinical associations of c-jun activation in human breast cancer
    • Gee JM, Barroso AF, Ellis IO et al. Biological and clinical associations of c-jun activation in human breast cancer. Int. J. Cancer 89, 177-186 (2000).
    • (2000) Int. J. Cancer , vol.89 , pp. 177-186
    • Gee, J.M.1    Barroso, A.F.2    Ellis, I.O.3
  • 12
    • 0037567489 scopus 로고    scopus 로고
    • Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1)
    • Kouvaraki MA, Rassidakis GZ, Tian L et al. Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Cancer Res. 63, 2977-2981 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2977-2981
    • Kouvaraki, M.A.1    Rassidakis, G.Z.2    Tian, L.3
  • 13
    • 0036272911 scopus 로고    scopus 로고
    • p53 gene mutations: Case study of a clinical marker for solid tumors
    • Liu MC, Gelmann, EP. p53 gene mutations: case study of a clinical marker for solid tumors. Semin. Oncol. 29, 246-257 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 246-257
    • Liu, M.C.1    Gelmann, E.P.2
  • 14
    • 0036129489 scopus 로고    scopus 로고
    • The p53 pathway in breast cancer
    • Gasco M, Shami S, Crook T. The p53 pathway in breast cancer. Breast Cancer Res. 4, 70-76 (2002). Overview of p53 status and correlation with other parameters.
    • (2002) Breast Cancer Res. , vol.4 , pp. 70-76
    • Gasco, M.1    Shami, S.2    Crook, T.3
  • 15
    • 0027316146 scopus 로고
    • Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer
    • Lohmann D, Ruhri C, Schmitt M et al. Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer. Diagn. Mol. Pathol. 2, 36-41 (1993).
    • (1993) Diagn. Mol. Pathol. , vol.2 , pp. 36-41
    • Lohmann, D.1    Ruhri, C.2    Schmitt, M.3
  • 16
    • 0028417998 scopus 로고
    • The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer
    • Bhargava V, Thor A, Deng G et al. The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer. Mod. Pathol. 7, 361-368 (1994).
    • (1994) Mod. Pathol. , vol.7 , pp. 361-368
    • Bhargava, V.1    Thor, A.2    Deng, G.3
  • 17
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumors to evaluate clinical outcome
    • Soussi T, Beroud C. Assessing TP53 status in human tumors to evaluate clinical outcome. Nature Rev. Cancer 1, 233-240 (2001). Thorough review of p53 testing in clinical samples: cautions against the use of immunohistochemistry (IHC).
    • (2001) Nature Rev. Cancer , vol.1 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 18
    • 0037221767 scopus 로고    scopus 로고
    • TP53 and breast cancer
    • Borresen-Dale AL. TP53 and breast cancer. Hum. Mutat. 21, 292-300 (2003).
    • (2003) Hum. Mutat. , vol.21 , pp. 292-300
    • Borresen-Dale, A.L.1
  • 19
    • 0026724877 scopus 로고
    • p53 tumor suppressor gene: An independent marker of prognosis in breast cancers
    • Thor AD, Moore DH, Edgerron SM et al. p53 tumor suppressor gene: an independent marker of prognosis in breast cancers. J. Natl Cancer Inst. 84, 845-855 (1992).
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 845-855
    • Thor, A.D.1    Moore, D.H.2    Edgerron, S.M.3
  • 20
    • 0028670132 scopus 로고
    • p53 gene expression in node positive breast cancer relationship to DNA ploidy and prognosis
    • Cunningham JM, Ingle JN, Jung SH et al. p53 gene expression in node positive breast cancer relationship to DNA ploidy and prognosis. J. Natl Cancer Inst. 86, 1871-1873 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1871-1873
    • Cunningham, J.M.1    Ingle, J.N.2    Jung, S.H.3
  • 21
    • 0028173703 scopus 로고
    • p53 gene mutations and steroid receptor status in breast carcinoma. Clinical pathologic correlations and prognostic assessment
    • Caleffi M, Teague MW, Jensen RA et al. p53 gene mutations and steroid receptor status in breast carcinoma. Clinical pathologic correlations and prognostic assessment. Cancer 73, 2147-2156 (1994).
    • (1994) Cancer , vol.73 , pp. 2147-2156
    • Caleffi, M.1    Teague, M.W.2    Jensen, R.A.3
  • 22
    • 0028209683 scopus 로고
    • Overexpression of p53 and Her-2/neu proteins as prognostic markers in early stage breast cancer
    • Marks JR, Humphrey PA, Wu K et al. Overexpression of p53 and Her-2/neu proteins as prognostic markers in early stage breast cancer. Ann. Surg. 219, 332-341 (1994).
    • (1994) Ann. Surg. , vol.219 , pp. 332-341
    • Marks, J.R.1    Humphrey, P.A.2    Wu, K.3
  • 23
    • 0028936940 scopus 로고
    • Usefulness of immunohistochemical staining for p53 in the prognosis of breast carcinomas: Correlation with established prognosis parameters and with the proliferation marker, MIB-1
    • Beck T, Weller EE, Weikel W et al. Usefulness of immunohistochemical staining for p53 in the prognosis of breast carcinomas: correlation with established prognosis parameters and with the proliferation marker, MIB-1. Gynecol. Oncol. 57, 96-104 (1995).
    • (1995) Gynecol. Oncol. , vol.57 , pp. 96-104
    • Beck, T.1    Weller, E.E.2    Weikel, W.3
  • 24
    • 0029073858 scopus 로고
    • Prognostic significance of p53 overexpression in primary breast cancer: A novel luminometric immunoassay applicable on steroid receptor cytosols
    • Borg A, Lennerstand J, Stenmark-Askmalm M et al. Prognostic significance of p53 overexpression in primary breast cancer: a novel luminometric immunoassay applicable on steroid receptor cytosols. Br. J. Cancer 71, 1013-1017 (1995).
    • (1995) Br. J. Cancer , vol.71 , pp. 1013-1017
    • Borg, A.1    Lennerstand, J.2    Stenmark-Askmalm, M.3
  • 25
    • 0029054770 scopus 로고
    • Oncogene protein co-expression. Value of H-ras, c-myc, c-fos and p53 as prognostic discriminants for breast carcinoma
    • Bland KI, Konstadoulakis MM, Vezeridis MP et al. Oncogene protein co-expression. Value of H-ras, c-myc, c-fos and p53 as prognostic discriminants for breast carcinoma. Ann. Surg. 221, 706-718 (1995).
    • (1995) Ann. Surg. , vol.221 , pp. 706-718
    • Bland, K.I.1    Konstadoulakis, M.M.2    Vezeridis, M.P.3
  • 26
    • 0028897737 scopus 로고
    • Prognostic significance of circulating p53 antibodies in patients undergoing surgery for local regional breast cancer
    • Peyrat J-P, Bonneterre J, Lubin R et al. Prognostic significance of circulating p53 antibodies in patients undergoing surgery for local regional breast cancer. Lancet 345, 621-622 (1995).
    • (1995) Lancet , vol.345 , pp. 621-622
    • Peyrat, J.-P.1    Bonneterre, J.2    Lubin, R.3
  • 27
    • 0029901997 scopus 로고    scopus 로고
    • p53 protein expression in human breast carcinoma: Lack of prognostic potential for recurrence of the disease
    • Katoh A, Breier S, Stemmler N et al. p53 protein expression in human breast carcinoma: lack of prognostic potential for recurrence of the disease. Anticancer Res. 16, 1301-1304 (1996).
    • (1996) Anticancer Res. , vol.16 , pp. 1301-1304
    • Katoh, A.1    Breier, S.2    Stemmler, N.3
  • 28
    • 1542303510 scopus 로고    scopus 로고
    • Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer
    • Soong R, Iacopetta BJ, Harvey JM et al. Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer. Clin. Cancer Res. 6, 443-451 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 443-451
    • Soong, R.1    Iacopetta, B.J.2    Harvey, J.M.3
  • 29
    • 0031919283 scopus 로고    scopus 로고
    • p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer
    • Clahsen PC, van de Velde CJ, Duval C et al. p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. J. Clin. Oncol. 16, 470-479 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 470-479
    • Clahsen, P.C.1    Van De Velde, C.J.2    Duval, C.3
  • 30
    • 0032548879 scopus 로고    scopus 로고
    • No significant predictive value of c-erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer
    • Rozan S, Vincent-Salomon A, Zafrani B et al. No significant predictive value of c-erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer. Int. J. Cancer 79, 27-33 (1998).
    • (1998) Int. J. Cancer , vol.79 , pp. 27-33
    • Rozan, S.1    Vincent-Salomon, A.2    Zafrani, B.3
  • 31
    • 0031929625 scopus 로고    scopus 로고
    • Prognostic value of p53 and urokinase-type plasminogen activator in node-negative human breast cancers
    • Peyrat JP, Vanlemmens L, Fournier et al. Prognostic value of p53 and urokinase-type plasminogen activator in node-negative human breast cancers. Clin. Cancer Res. 4, 189-196 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 189-196
    • Peyrat, J.P.1    Vanlemmens, L.2    Fournier3
  • 32
    • 0031927693 scopus 로고    scopus 로고
    • Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: A prognostic factor in a large breast cancer cohort
    • Levesque MA, Yu H, Clark GM, Diamandis EP. Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: a prognostic factor in a large breast cancer cohort. J. Clin. Oncol. 16, 2641-2650 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2641-2650
    • Levesque, M.A.1    Yu, H.2    Clark, G.M.3    Diamandis, E.P.4
  • 33
    • 0032441703 scopus 로고    scopus 로고
    • Relevance of the expression of bcl-2 in combination with p53 as a prognostic factor in breast cancer
    • Jansen RL Joosten-Achjanie SR, Volovics A et al. Relevance of the expression of bcl-2 in combination with p53 as a prognostic factor in breast cancer. Anticancer Res. 18, 4455-4462 (1998).
    • (1998) Anticancer Res. , vol.18 , pp. 4455-4462
    • Jansen, R.L.1    Joosten-Achjanie, S.R.2    Volovics, A.3
  • 34
    • 0032944657 scopus 로고    scopus 로고
    • Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-Year median follow-up
    • Harbeck N, Dettmar P, Thomssen C et al. Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-year median follow-up. Br. J. Cancer 80, 419-426 (1999).
    • (1999) Br. J. Cancer , vol.80 , pp. 419-426
    • Harbeck, N.1    Dettmar, P.2    Thomssen, C.3
  • 35
    • 0032938496 scopus 로고    scopus 로고
    • Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: A multicentre study
    • Broet P, Spyratos F, Romain S et al. Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicentre study. Br. J. Cancer 80, 536-545 (1999).
    • (1999) Br. J. Cancer , vol.80 , pp. 536-545
    • Broet, P.1    Spyratos, F.2    Romain, S.3
  • 36
    • 0034651899 scopus 로고    scopus 로고
    • The prognostic value of p53 and c-erb Bcl-2 immunostaining is overrated for patients with lymph node negative breast carcinoma: A multivariate analysis of prognostic factors in 613 patients with a follow-up of 14-30 years
    • Reed W, Hannisdal E, Boehler PJ et al. The prognostic value of p53 and c-erb Bcl-2 immunostaining is overrated for patients with lymph node negative breast carcinoma: a multivariate analysis of prognostic factors in 613 patients with a follow-up of 14-30 years. Cancer 88, 804-813 (2000).
    • (2000) Cancer , vol.88 , pp. 804-813
    • Reed, W.1    Hannisdal, E.2    Boehler, P.J.3
  • 37
    • 17744403009 scopus 로고    scopus 로고
    • Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer
    • Berns EM, Foekens JA, Vossen R et al. Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer. Cancer Res. 60, 2155-2162 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2155-2162
    • Berns, E.M.1    Foekens, J.A.2    Vossen, R.3
  • 38
    • 0034029990 scopus 로고    scopus 로고
    • P53 determination alongside classical prognostic factors in node-negative breast cancer: An evaluation at more than 10-year follow-up
    • Ferrero JM, Ramaioli A, Formento JL et al. P53 determination alongside classical prognostic factors in node-negative breast cancer: an evaluation at more than 10-year follow-up. Ann. Oncol. 11, 393-397 (2000).
    • (2000) Ann. Oncol. , vol.11 , pp. 393-397
    • Ferrero, J.M.1    Ramaioli, A.2    Formento, J.L.3
  • 39
    • 0033926876 scopus 로고    scopus 로고
    • p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients
    • Bottini A, Berruti A, Bersiga A et al. p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients. Clin. Cancer Res. 6, 2751-2758 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2751-2758
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3
  • 40
    • 0035866772 scopus 로고    scopus 로고
    • Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
    • Geisler S, Lonning PE, Aas T et al. Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res. 61, 2505-2512 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2505-2512
    • Geisler, S.1    Lonning, P.E.2    Aas, T.3
  • 41
    • 0034853143 scopus 로고    scopus 로고
    • Prognostic value of cytosolic p53 protein in breast cancer
    • Montero S, Guzman C, Vargas C et al. Prognostic value of cytosolic p53 protein in breast cancer. Tumour Biol 22, 337-344 (2001).
    • (2001) Tumour Biol. , vol.22 , pp. 337-344
    • Montero, S.1    Guzman, C.2    Vargas, C.3
  • 42
    • 0035225608 scopus 로고    scopus 로고
    • Prognostic value of p53 protein expression in breast cancer an immunohistochemical analysis of frozen sections in 514 Japanese women
    • Tsutsui S, Ohno S, Murakam S et al. Prognostic value of p53 protein expression in breast cancer an immunohistochemical analysis of frozen sections in 514 Japanese women. Breast Cancer 8, 194-201 (2001).
    • (2001) Breast Cancer , vol.8 , pp. 194-201
    • Tsutsui, S.1    Ohno, S.2    Murakam, S.3
  • 43
    • 0036491857 scopus 로고    scopus 로고
    • An immunohistochemical study of p21 and p53 expression in primary node-positive breast carcinoma
    • O'Hanlon DM, Kiely M, MacConmara M et al. An immunohistochemical study of p21 and p53 expression in primary node-positive breast carcinoma. Eur J. Surg. Oncol. 28, 103-107 (2002).
    • (2002) Eur J. Surg. Oncol. , vol.28 , pp. 103-107
    • O'Hanlon, D.M.1    Kiely, M.2    MacConmara, M.3
  • 44
    • 0034880884 scopus 로고    scopus 로고
    • p53 mutation in plasma DNA and its prognostic value in breast cancer patients
    • Shao ZM, Wu J, Shen ZZ et al. p53 mutation in plasma DNA and its prognostic value in breast cancer patients. Clin. Cancer Res. 7, 2222-2227 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2222-2227
    • Shao, Z.M.1    Wu, J.2    Shen, Z.Z.3
  • 45
    • 0036329331 scopus 로고    scopus 로고
    • p53, mitosis, apoptosis and necrosis as prognostic indicators of long-term survival in breast cancer
    • Kato T, Kameoka S, Kimura T et al. p53, mitosis, apoptosis and necrosis as prognostic indicators of long-term survival in breast cancer. Anticancer Res. 22, 1105-1112 (2002).
    • (2002) Anticancer Res. , vol.22 , pp. 1105-1112
    • Kato, T.1    Kameoka, S.2    Kimura, T.3
  • 46
    • 0027325267 scopus 로고
    • Prediction of early relapse and shortened survival in patients with breast cancer by proliferating cell nuclear antigen score
    • Tahan SR, Neuberg DS, Dieffenbach A et al. Prediction of early relapse and shortened survival in patients with breast cancer by proliferating cell nuclear antigen score. Cancer 71, 3552-3559 (1993).
    • (1993) Cancer , vol.71 , pp. 3552-3559
    • Tahan, S.R.1    Neuberg, D.S.2    Dieffenbach, A.3
  • 47
    • 0036725482 scopus 로고    scopus 로고
    • p53 and c-erbB-2 but not bcl-2 are predictive of metastasis-free survival in breast cancer patients receiving post-mastectomy adjuvant radiotherapy in Taiwan
    • Chen HH, Su WC, Guo HR et al. p53 and c-erbB-2 but not bcl-2 are predictive of metastasis-free survival in breast cancer patients receiving post-mastectomy adjuvant radiotherapy in Taiwan. Jpn. J. Clin. Oncol. 32, 332-339 (2002).
    • (2002) Jpn. J. Clin. Oncol. , vol.32 , pp. 332-339
    • Chen, H.H.1    Su, W.C.2    Guo, H.R.3
  • 48
    • 0027316146 scopus 로고
    • Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer
    • Lohmann D, Ruhri C, Schmitt M et al. Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer. Diagn. Mol. Pathol. 2, 36-41 (1993).
    • (1993) Diagn. Mol. Pathol. , vol.2 , pp. 36-41
    • Lohmann, D.1    Ruhri, C.2    Schmitt, M.3
  • 49
    • 0028417998 scopus 로고
    • The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer
    • Bhargava V, Thor A, Deng G et al. The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer. Mod. Pathol. 7, 361-368 (1994).
    • (1994) Mod. Pathol. , vol.7 , pp. 361-368
    • Bhargava, V.1    Thor, A.2    Deng, G.3
  • 50
    • 0029020615 scopus 로고
    • Mutant p53 expression and DNA analysis in human breast cancer. Comparison with conventional clinicopathological parameters
    • Rosanelli GP, Steindorfer P, Wirnsberger GH et al. Mutant p53 expression and DNA analysis in human breast cancer. Comparison with conventional clinicopathological parameters. Anticancer Res. 15, 581-586 (1995).
    • (1995) Anticancer Res. , vol.15 , pp. 581-586
    • Rosanelli, G.P.1    Steindorfer, P.2    Wirnsberger, G.H.3
  • 51
    • 0028145704 scopus 로고
    • Expression of proliferating cell nuclear antigen, Ki-67 antigen, estrogen receptor protein and tumor suppressor p53 gene in cytologic samples of breast cancer: An immunochemical study with clinical, pathobiological, and histologic correlations
    • Pelosi G, Bresaola E, Rodella S et al. Expression of proliferating cell nuclear antigen, Ki-67 antigen, estrogen receptor protein and tumor suppressor p53 gene in cytologic samples of breast cancer: an immunochemical study with clinical, pathobiological, and histologic correlations. Diagn. Cytopathol. 11, 131-140 (1994).
    • (1994) Diagn. Cytopathol. , vol.11 , pp. 131-140
    • Pelosi, G.1    Bresaola, E.2    Rodella, S.3
  • 52
    • 0032763581 scopus 로고    scopus 로고
    • Biological markers as indicators of response to primary and adjuvant chemotherapy in breast cancer
    • Daidone MG, Veneroni S, Benini E et al. Biological markers as indicators of response to primary and adjuvant chemotherapy in breast cancer. Int. J. Cancer 84, 580-586 (1999).
    • (1999) Int. J. Cancer , vol.84 , pp. 580-586
    • Daidone, M.G.1    Veneroni, S.2    Benini, E.3
  • 53
    • 0033971806 scopus 로고    scopus 로고
    • TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients
    • Kandioler-Eckersberger D, Ludwig C, Rudas M et al. TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin. Cancer Res. 6, 50-56 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 50-56
    • Kandioler-Eckersberger, D.1    Ludwig, C.2    Rudas, M.3
  • 54
    • 0037077831 scopus 로고    scopus 로고
    • Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy
    • Bertheau P, Plassa F, Espie M et al. Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet 360, 852-854 (2002).
    • (2002) Lancet , vol.360 , pp. 852-854
    • Bertheau, P.1    Plassa, F.2    Espie, M.3
  • 55
    • 0343517136 scopus 로고    scopus 로고
    • Predictive value of p53, mdm-2, p21 and mib-1 for chemotherapy response in advanced breast cancer
    • Sjostrom J, Blomqvist C, Heikkila P et al. Predictive value of p53, mdm-2, p21 and mib-1 for chemotherapy response in advanced breast cancer. Clin. Cancer Res. 6, 3103-3110 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3103-3110
    • Sjostrom, J.1    Blomqvist, C.2    Heikkila, P.3
  • 56
    • 0036569471 scopus 로고    scopus 로고
    • Assessment of molecular markers of clinical sensitivity to single-agent taxane therapy for metastatic breast cancer
    • Van Poznak C, Tan L, Panageas KS et al. Assessment of molecular markers of clinical sensitivity to single-agent taxane therapy for metastatic breast cancer. J. Clin. Oncol. 20, 2319-2926 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2319-2926
    • Van Poznak, C.1    Tan, L.2    Panageas, K.S.3
  • 57
    • 0034309153 scopus 로고    scopus 로고
    • A study of the value of p53, HER2 and Bcl-2 in the prediction of response to doxorubicin and paclitaxel as single agents in metastatic breast cancer: A companion study to EORTC 10923
    • Hamilton A, Larsiniont D, Paridaens R et al. A study of the value of p53, HER2 and Bcl-2 in the prediction of response to doxorubicin and paclitaxel as single agents in metastatic breast cancer: a companion study to EORTC 10923. Clin. Breast Cancer 1, 233-240 (2000).
    • (2000) Clin. Breast Cancer , vol.1 , pp. 233-240
    • Hamilton, A.1    Larsiniont, D.2    Paridaens, R.3
  • 58
    • 0035879210 scopus 로고    scopus 로고
    • Value of epidermal growth factor receptor, HER2, p53 and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients
    • Knoop AS, Bentzen SM, Nielsen MM et al. Value of epidermal growth factor receptor, HER2, p53 and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients. J. Clin. Oncol. 19, 3376-3384 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3376-3384
    • Knoop, A.S.1    Bentzen, S.M.2    Nielsen, M.M.3
  • 59
    • 0027993963 scopus 로고
    • MDM2 gene amplification in human breast cancer
    • Quesnel B, Preudhomme C, Fournier J et al. MDM2 gene amplification in human breast cancer. Eur. J. Cancer 30A, 982-984 (1994).
    • (1994) Eur. J. Cancer , vol.30 A , pp. 982-984
    • Quesnel, B.1    Preudhomme, C.2    Fournier, J.3
  • 60
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDMp53 protein status
    • McCann AH, Kirley A, Carney DN et al. Amplification of the MDM2 gene in human breast cancer and its association with MDMp53 protein status. Br. J. Cancer 71, 981-985 (1995).
    • (1995) Br. J. Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1    Kirley, A.2    Carney, D.N.3
  • 62
    • 0030667191 scopus 로고    scopus 로고
    • p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis
    • Jiang M, Shao ZM, Wu J et al. p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis. Int. J. Cancer 74, 529-534 (1997).
    • (1997) Int. J. Cancer , vol.74 , pp. 529-534
    • Jiang, M.1    Shao, Z.M.2    Wu, J.3
  • 63
    • 0034181941 scopus 로고    scopus 로고
    • Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with anthracycline
    • Mathoulin-Portier MP, Viens P, Cowen D et al. Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with anthracycline. Oncol. Rep. 7, 675-680 (2000).
    • (2000) Oncol. Rep. , vol.7 , pp. 675-680
    • Mathoulin-Portier, M.P.1    Viens, P.2    Cowen, D.3
  • 64
    • 0034652452 scopus 로고    scopus 로고
    • Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
    • Cuny M, Kramar A, Courjal F et al. Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations. Cancer Res. 60, 1077-1083 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1077-1083
    • Cuny, M.1    Kramar, A.2    Courjal, F.3
  • 65
    • 0343628888 scopus 로고    scopus 로고
    • Clinical relevance of immunohistochemical expression of p53-targeted gene products mdm-2, p21 and bcl-2 in breast carcinoma
    • Bankfalvi A, Tory K, Kemper M et al. Clinical relevance of immunohistochemical expression of p53-targeted gene products mdm-2, p21 and bcl-2 in breast carcinoma. Pathol. Res. Pract. 196, 489-501 (2000).
    • (2000) Pathol. Res. Pract. , vol.196 , pp. 489-501
    • Bankfalvi, A.1    Tory, K.2    Kemper, M.3
  • 66
    • 0025615654 scopus 로고
    • The retinoblastoma gene: Its role in human malignancies
    • Benedict WF, Xu H-J, Takahashi R. The retinoblastoma gene: its role in human malignancies. Cancer Invest. 8, 535-540 (1990).
    • (1990) Cancer Invest. , vol.8 , pp. 535-540
    • Benedict, W.F.1    Xu, H.-J.2    Takahashi, R.3
  • 67
    • 0024309158 scopus 로고
    • The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumors
    • Varley JM, Armour J, Swallow JE et al. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumors. Oncogene 4, 725-729 (1989).
    • (1989) Oncogene , vol.4 , pp. 725-729
    • Varley, J.M.1    Armour, J.2    Swallow, J.E.3
  • 68
    • 0028918906 scopus 로고
    • Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival
    • Berns EM, de Klein A, van Putten WL et al. Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival. Int. J. Cancer 64, 140-145 (1995).
    • (1995) Int. J. Cancer , vol.64 , pp. 140-145
    • Berns, E.M.1    De Klein, A.2    Van Putten, W.L.3
  • 70
    • 0007831448 scopus 로고    scopus 로고
    • Analysis of nm23-H 1 expression in breast cancer. Correlation with p53 expression and clinicopathologic findings
    • Duenas-Gonzalez A, Abad-Hernandez MM, Garcia-Mata J et al. Analysis of nm23-H1 expression in breast cancer. Correlation with p53 expression and clinicopathologic findings. Cancer Lett. 101, 137-142 (1996).
    • (1996) Cancer Lett. , vol.101 , pp. 137-142
    • Duenas-Gonzalez, A.1    Abad-Hernandez, M.M.2    Garcia-Mata, J.3
  • 71
    • 0035286373 scopus 로고    scopus 로고
    • Loss of nm23 expression predicts distal metastases and poorer survival for breast cancer
    • Mao H, Liu H, Fu X et al. Loss of nm23 expression predicts distal metastases and poorer survival for breast cancer. Int. J. Oncol. 18, 587-591 (2001).
    • (2001) Int. J. Oncol. , vol.18 , pp. 587-591
    • Mao, H.1    Liu, H.2    Fu, X.3
  • 72
    • 17044449230 scopus 로고    scopus 로고
    • Decreased nm23 expression but not Ki-67 labeling index, is significantly correlated with lymph node metastasis of breast invasive ductal carcinoma
    • Terasaki-Fukuzawa Y, Kijima H, Suto A et al. Decreased nm23 expression but not Ki-67 labeling index, is significantly correlated with lymph node metastasis of breast invasive ductal carcinoma. Int. J. Mol. Med 9, 25-29 (2002).
    • (2002) Int. J. Mol. Med. , vol.9 , pp. 25-29
    • Terasaki-Fukuzawa, Y.1    Kijima, H.2    Suto, A.3
  • 73
    • 0036834180 scopus 로고    scopus 로고
    • Lack of prognostic significance of nm23 expression in human primary breast cancer
    • Gohring UJ, Eustermann I, Becker M et al. Lack of prognostic significance of nm23 expression in human primary breast cancer. Oncol. Rep. 9, 1205-1208 (2002).
    • (2002) Oncol. Rep. , vol.9 , pp. 1205-1208
    • Gohring, U.J.1    Eustermann, I.2    Becker, M.3
  • 74
    • 0036354295 scopus 로고    scopus 로고
    • Nm23 gene product expression in invasive breast cancer: Immunohistochemical analysis and clinicopathological correlation
    • Belev B, Aleric I, Vrbanec D et al. Nm23 gene product expression in invasive breast cancer: immunohistochemical analysis and clinicopathological correlation. Acta Oncol 41, 355-361 (2002).
    • (2002) Acta Oncol. , vol.41 , pp. 355-361
    • Belev, B.1    Aleric, I.2    Vrbanec, D.3
  • 75
    • 0035193372 scopus 로고    scopus 로고
    • Negative regulators of cyclin-dependent kinases and their roles in cancers
    • Lee MH, Yang HY. Negative regulators of cyclin-dependent kinases and their roles in cancers. Cell. Mol. Life Sci. 58, 1907-1922 (2001).
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 1907-1922
    • Lee, M.H.1    Yang, H.Y.2
  • 76
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • Sherr CJ. The INK4a/ARF network in tumour suppression. Nature Rev. Mol. Cell. Biol. 2, 731-737 (2001).
    • (2001) Nature Rev. Mol. Cell. Biol. , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 77
    • 0037068312 scopus 로고    scopus 로고
    • CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future
    • Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 21, 5427-5440 (2002).
    • (2002) Oncogene , vol.21 , pp. 5427-5440
    • Esteller, M.1
  • 78
    • 0033926203 scopus 로고    scopus 로고
    • INK4a gene expression and methylation in primary breast cancer: Overexpression of p 16INK4a messenger RNA is a marker of poor prognosis
    • Hui R, Macmillan RD, Kenny FS et al. INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis. Clin. Cancer. Res. 6, 2777-2787 (2000).
    • (2000) Clin. Cancer. Res. , vol.6 , pp. 2777-2787
    • Hui, R.1    Macmillan, R.D.2    Kenny, F.S.3
  • 79
    • 0035672499 scopus 로고    scopus 로고
    • P16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy
    • Han S, Ahn SH, Park K et al. P16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy. Breast Cancer Res. Treat. 70, 205-212 (2001).
    • (2001) Breast Cancer Res. Treat. , vol.70 , pp. 205-212
    • Han, S.1    Ahn, S.H.2    Park, K.3
  • 80
    • 0034895071 scopus 로고    scopus 로고
    • Overexpression of the p 16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype
    • Milde-Langosch K, Bamberger AM, Rieck G et al. Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res. Treat. 67, 61-70 (2001).
    • (2001) Breast Cancer Res. Treat. , vol.67 , pp. 61-70
    • Milde-Langosch, K.1    Bamberger, A.M.2    Rieck, G.3
  • 81
    • 0030862422 scopus 로고    scopus 로고
    • Expression of p16 and cyclin-dependent kinase 4 proteins in primary breast carcinomas
    • Ito Y, Kobayashi T, Takeda T et al. Expression of p16 and cyclin-dependent kinase 4 proteins in primary breast carcinomas. Oncology 54, 508-515 (1997).
    • (1997) Oncology , vol.54 , pp. 508-515
    • Ito, Y.1    Kobayashi, T.2    Takeda, T.3
  • 82
    • 0037028211 scopus 로고    scopus 로고
    • Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer
    • Span PN, Manders P, Heuvel JJ et al. Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer. Oncogene 21, 8506-8509 (2002).
    • (2002) Oncogene , vol.21 , pp. 8506-8509
    • Span, P.N.1    Manders, P.2    Heuvel, J.J.3
  • 83
    • 0035168724 scopus 로고    scopus 로고
    • The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumori genesis, prognosis and therapy
    • Mills GB, Lu Y, Fang X et al. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis and therapy. Semin. Oncol. 28, 125-141 (2001).
    • (2001) Semin. Oncol. , vol.28 , pp. 125-141
    • Mills, G.B.1    Lu, Y.2    Fang, X.3
  • 84
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo LD, Donner DB. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem. Sci. 27, 462-467 (2002).
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 85
    • 0034920457 scopus 로고    scopus 로고
    • Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
    • Depowski PL, Rosenthal SI, Ross JS. Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod. Pathol. 14, 672-676 (2001).
    • (2001) Mod. Pathol. , vol.14 , pp. 672-676
    • Depowski, P.L.1    Rosenthal, S.I.2    Ross, J.S.3
  • 86
    • 0034777184 scopus 로고    scopus 로고
    • Decline in the expression of the serine proteinase inhibitor maspin is associated with tumor progression in ductal carcinomas of the breast
    • Maas N, Teffner M, Rosel F et al. Decline in the expression of the serine proteinase inhibitor maspin is associated with tumor progression in ductal carcinomas of the breast. J. Pathol. 195, 321-326 (2001).
    • (2001) J. Pathol. , vol.195 , pp. 321-326
    • Maas, N.1    Teffner, M.2    Rosel, F.3
  • 87
    • 0036681258 scopus 로고    scopus 로고
    • Expression of maspin predicts poor prognosis in breast cancer patients
    • Umekita Y, Ohi Y, Sagara Y et al. Expression of maspin predicts poor prognosis in breast cancer patients. Int. J. Cancer 100, 452-455 (2002).
    • (2002) Int. J. Cancer , vol.100 , pp. 452-455
    • Umekita, Y.1    Ohi, Y.2    Sagara, Y.3
  • 88
    • 0035702477 scopus 로고    scopus 로고
    • Maspin and mammaglobin genes are specific markers for RT-PCR detection of minimal residual disease in patients with breast cancer
    • Corradini P, Voena C, Astolfi M et al. Maspin and mammaglobin genes are specific markers for RT-PCR detection of minimal residual disease in patients with breast cancer. Ann. Oncol. 12, 1693-1698 (2001).
    • (2001) Ann. Oncol. , vol.12 , pp. 1693-1698
    • Corradini, P.1    Voena, C.2    Astolfi, M.3
  • 89
    • 0344406870 scopus 로고    scopus 로고
    • Maspin expression in invasive breast cancer association with other prognostic factors
    • Mohsin SK, Zhang M, Clark GM et al. Maspin expression in invasive breast cancer association with other prognostic factors. J. Pathol 199, 432-435 (2003).
    • (2003) J. Pathol. , vol.199 , pp. 432-435
    • Mohsin, S.K.1    Zhang, M.2    Clark, G.M.3
  • 90
    • 26144471190 scopus 로고    scopus 로고
    • Hypermethylation of BRCA1 promoter in sporadic breast cancer: Comparison with BRCA1 associated breast cancer
    • Abstract 26
    • Wei M, Grushko T, Hagos F et al. Hypermethylation of BRCA1 promoter in sporadic breast cancer: comparison with BRCA1 associated breast cancer. Breast Cancer Res. Treat. 76(Suppl. 1), S35 (2002) (Abstract 26).
    • (2002) Breast Cancer Res. Treat. , vol.76 , Issue.SUPPL. 1
    • Wei, M.1    Grushko, T.2    Hagos, F.3
  • 91
    • 0034484047 scopus 로고    scopus 로고
    • Adhesion molecules in cancer biology
    • Ohene-Abuakwa Y, Pignatelli M. Adhesion molecules in cancer biology. Adv. Exp. Med. Biol. 465, 115-126 (2000). Overview of cell adhesion molecule biology in cancer and potential roles in invasion and metastasis.
    • (2000) Adv. Exp. Med. Biol. , vol.465 , pp. 115-126
    • Ohene-Abuakwa, Y.1    Pignatelli, M.2
  • 92
    • 0036369890 scopus 로고    scopus 로고
    • Adhesion molecules
    • Skubitz AP. Adhesion molecules. Cancer Treat. Res. 107, 305-329 (2002).
    • (2002) Cancer Treat. Res. , vol.107 , pp. 305-329
    • Skubitz, A.P.1
  • 93
    • 0034852853 scopus 로고    scopus 로고
    • The E-cadherin/catenin complex: An important gatekeeper in breast cancer tumorigenesis and malignant progression
    • Berx G, Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res. 3, 289-293 (2001).
    • (2001) Breast Cancer Res. , vol.3 , pp. 289-293
    • Berx, G.1    Van Roy, F.2
  • 94
    • 0033777043 scopus 로고    scopus 로고
    • Catenins, Wnt signaling and cancer
    • Barker N, Clevers H. Catenins, Wnt signaling and cancer. Bioassays 22, 961-965 (2000).
    • (2000) Bioassays , vol.22 , pp. 961-965
    • Barker, N.1    Clevers, H.2
  • 95
    • 0033930954 scopus 로고    scopus 로고
    • E-cadherin/catenin cell-cell adhesion complex and human cancer
    • Wijnhoven BP, Dinjens WN, Pignatelli M. E-cadherin/catenin cell-cell adhesion complex and human cancer. Br. J. Surg. 87, 992-1005 (2000).
    • (2000) Br. J. Surg. , vol.87 , pp. 992-1005
    • Wijnhoven, B.P.1    Dinjens, W.N.2    Pignatelli, M.3
  • 96
    • 0033853424 scopus 로고    scopus 로고
    • The E-cadherin-catenin complex in tumour metastasis: Structure, function and regulation
    • Beavon IR. The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. Eur. J. Cancer 36, 1607-1620 (2000).
    • (2000) Eur. J. Cancer , vol.36 , pp. 1607-1620
    • Beavon, I.R.1
  • 97
    • 0031948671 scopus 로고    scopus 로고
    • Reduced E-cadherin immunohistochemical expression in node-negative breast carcinomas correlates with 10-year survival
    • Charpin C, Garcia S, Bonnier P et al. Reduced E-cadherin immunohistochemical expression in node-negative breast carcinomas correlates with 10-year survival. Am. J. Clin. Pathol 109, 431-438 (1998).
    • (1998) Am. J. Clin. Pathol. , vol.109 , pp. 431-438
    • Charpin, C.1    Garcia, S.2    Bonnier, P.3
  • 98
    • 0035555657 scopus 로고    scopus 로고
    • E-cadherin as a prognostic indicator in primary breast cancer
    • Parker C, Rampaul RS, Pinder SE et al. E-cadherin as a prognostic indicator in primary breast cancer. Br. J. Cancer 85, 1958-1963 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 1958-1963
    • Parker, C.1    Rampaul, R.S.2    Pinder, S.E.3
  • 99
    • 0035286576 scopus 로고    scopus 로고
    • The loss of E-cadherin, α- and β-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer
    • Yoshida R, Kimura N, Harada Y et al. The loss of E-cadherin, α- and β-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer. Int. J. Oncol. 18, 513-520 (2001).
    • (2001) Int. J. Oncol. , vol.18 , pp. 513-520
    • Yoshida, R.1    Kimura, N.2    Harada, Y.3
  • 100
    • 0035068950 scopus 로고    scopus 로고
    • Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast
    • Gillett CE, Miles DW, Ryder K et al. Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast. J. Pathol. 193, 433-441 (2001).
    • (2001) J. Pathol. , vol.193 , pp. 433-441
    • Gillett, C.E.1    Miles, D.W.2    Ryder, K.3
  • 101
    • 0035963314 scopus 로고    scopus 로고
    • Mechanisms of inactivation of E-cadherin in breast carcinoma: Modification of the two-hit hypothesis of tumor suppressor gene
    • Cheng CW, Wu PE, Yu JC et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20, 3814-3823 (2001).
    • (2001) Oncogene , vol.20 , pp. 3814-3823
    • Cheng, C.W.1    Wu, P.E.2    Yu, J.C.3
  • 102
    • 85067959762 scopus 로고    scopus 로고
    • Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast
    • Reis-Filho JS, Cancela Paredes J, Milanezi F et al. Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast. Cancer 94, 2114-2115 (2002).
    • (2002) Cancer , vol.94 , pp. 2114-2115
    • Reis-Filho, J.S.1    Cancela Paredes, J.2    Milanezi, F.3
  • 103
    • 0035347391 scopus 로고    scopus 로고
    • Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast
    • Chan JK, Wong CS. Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast. Adv. Anat. Pathol. 8, 165-172 (2001).
    • (2001) Adv. Anat. Pathol. , vol.8 , pp. 165-172
    • Chan, J.K.1    Wong, C.S.2
  • 104
    • 0035031712 scopus 로고    scopus 로고
    • Persistent E-cadherin expression in inflammatory breast cancer
    • Kleer CG, van Golen KL, Braun T et al. Persistent E-cadherin expression in inflammatory breast cancer. Mod. Pathol. 14, 458-464 (2001).
    • (2001) Mod. Pathol. , vol.14 , pp. 458-464
    • Kleer, C.G.1    Van Golen, K.L.2    Braun, T.3
  • 105
    • 0035404863 scopus 로고    scopus 로고
    • CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    • Burguignon LY. CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression. J. Mammary Gland Biol. Neoplasia 6, 287-297 (2001).
    • (2001) J. Mammary Gland Biol. Neoplasia , vol.6 , pp. 287-297
    • Burguignon, L.Y.1
  • 106
    • 0027725152 scopus 로고
    • Glycoprotein CD44 expression and its association with survival in breast cancer
    • Joensuu H, Klemi PJ, Toikkanen S et al. Glycoprotein CD44 expression and its association with survival in breast cancer. Am. J. Pathol. 143, 866-874 (1993).
    • (1993) Am. J. Pathol. , vol.143 , pp. 866-874
    • Joensuu, H.1    Klemi, P.J.2    Toikkanen, S.3
  • 107
    • 0033064550 scopus 로고    scopus 로고
    • Prognostic value of CD44 variant expression in primary breast cancer
    • Foekens JA, Dall P, Klijn JG et al. Prognostic value of CD44 variant expression in primary breast cancer. Int. J. Cancer 84, 209-215 (1999).
    • (1999) Int. J. Cancer , vol.84 , pp. 209-215
    • Foekens, J.A.1    Dall, P.2    Klijn, J.G.3
  • 108
    • 0030849265 scopus 로고    scopus 로고
    • CD44 isoforms with exon v6 and metastasis of primary N0M0 breast carcinomas
    • Guriec N, Gairard B, Marcellin L et al. CD44 isoforms with exon v6 and metastasis of primary N0M0 breast carcinomas. Breast Cancer Res. Treat. 44, 261-268 (1997).
    • (1997) Breast Cancer Res. Treat. , vol.44 , pp. 261-268
    • Guriec, N.1    Gairard, B.2    Marcellin, L.3
  • 109
    • 0029987561 scopus 로고    scopus 로고
    • A CD44 variant exon 6 epitope as a prognostic indicator in breast cancer
    • Schumacher U, Horny HP, Horst HA et al. A CD44 variant exon 6 epitope as a prognostic indicator in breast cancer. Eur. J. Surg. Oncol. 22, 259-261 (1996).
    • (1996) Eur. J. Surg. Oncol. , vol.22 , pp. 259-261
    • Schumacher, U.1    Horny, H.P.2    Horst, H.A.3
  • 110
    • 0034853807 scopus 로고    scopus 로고
    • The prognostic significance of CD44s and CD44v6 expression in Stage II breast carcinoma: An immunohistochemical study
    • Morris SF, O'Hanlon DM, McLaughlin R et al. The prognostic significance of CD44s and CD44v6 expression in Stage II breast carcinoma: an immunohistochemical study. Eur. J. Surg. Oncol. 27, 527-531 (2001).
    • (2001) Eur. J. Surg. Oncol. , vol.27 , pp. 527-531
    • Morris, S.F.1    O'Hanlon, D.M.2    McLaughlin, R.3
  • 111
    • 0031928853 scopus 로고    scopus 로고
    • CD44v6 is not a prognostic factor in primary breast cancer
    • Jansen RH, Joosten-Achjanie SR, Arends JW et al. CD44v6 is not a prognostic factor in primary breast cancer. Ann. Oncol 9, 109-111 (1998).
    • (1998) Ann. Oncol. , vol.9 , pp. 109-111
    • Jansen, R.H.1    Joosten-Achjanie, S.R.2    Arends, J.W.3
  • 112
    • 0032696397 scopus 로고    scopus 로고
    • Evaluation of the prognostic value of serum soluble CD44 in patients with breast cancer
    • Sheen-Chen SM, Chen WJ, Eng HL et al. Evaluation of the prognostic value of serum soluble CD44 in patients with breast cancer. Cancer Invest. 17, 581-585 (1999).
    • (1999) Cancer Invest. , vol.17 , pp. 581-585
    • Sheen-Chen, S.M.1    Chen, W.J.2    Eng, H.L.3
  • 113
    • 0035162461 scopus 로고    scopus 로고
    • Predictive relevance of soluble CD44v6 serum levels for the responsiveness to second line hormone- or chemotherapy in patients with metastatic breast cancer
    • Kopp R, Classen S, Wolf H et al. Predictive relevance of soluble CD44v6 serum levels for the responsiveness to second line hormone- or chemotherapy in patients with metastatic breast cancer. Anticancer Res. 21, 2995-3000 (2001).
    • (2001) Anticancer Res. , vol.21 , pp. 2995-3000
    • Kopp, R.1    Classen, S.2    Wolf, H.3
  • 114
    • 0033969626 scopus 로고    scopus 로고
    • Adhesion receptors and cell invasion: Mechanisms of integrin-guided degradation of extracellular matrix
    • Ivaska J, Heino J. Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix. Cell. Mol. Life Sci. 57, 16-24 (2000).
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 16-24
    • Ivaska, J.1    Heino, J.2
  • 115
    • 0025271455 scopus 로고
    • Independent prognostic value on laminin receptor expression in breast cancer survival
    • Marques LA, Franco ELF, Tortoni H et al. Independent prognostic value on laminin receptor expression in breast cancer survival. Cancer Res. 50, 1479-1483 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 1479-1483
    • Marques, L.A.1    Franco, E.L.F.2    Tortoni, H.3
  • 116
    • 0026131489 scopus 로고
    • Augmentation of Type IV collagenase laminin receptor and ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression
    • D-Errico A, Garbisa S, Liotta LA et al. Augmentation of Type IV collagenase laminin receptor and ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression. Mod. Pathol. 4, 239-246 (1991).
    • (1991) Mod. Pathol. , vol.4 , pp. 239-246
    • D-Errico, A.1    Garbisa, S.2    Liotta, L.A.3
  • 117
    • 0025894118 scopus 로고
    • Laminin receptors, collagenase IV and prognosis in node-negative breast cancers
    • Daidone MG, Silvestrini R, D'Errico A et al. Laminin receptors, collagenase IV and prognosis in node-negative breast cancers. Int. J. Cancer 48, 529-532 (1991).
    • (1991) Int. J. Cancer , vol.48 , pp. 529-532
    • Daidone, M.G.1    Silvestrini, R.2    D'Errico, A.3
  • 118
    • 0026131489 scopus 로고
    • Augmentation of Type IV collagenase laminin receptor and ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression
    • D-Errico A, Garbisa S, Liotta LA et al. Augmentation of Type IV collagenase laminin receptor and ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression. Mod. Pathol. 4, 239-246 (1991).
    • (1991) Mod. Pathol. , vol.4 , pp. 239-246
    • D-Errico, A.1    Garbisa, S.2    Liotta, L.A.3
  • 119
    • 0031724191 scopus 로고    scopus 로고
    • Vascular integrin α(v)β 3, a new prognostic indicator in breast cancer
    • Gasparini G, Brooks PC, Biganzoli E et al. Vascular integrin α(v)β3, a new prognostic indicator in breast cancer. Clin. Cancer Res. 4, 2625-2634 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2625-2634
    • Gasparini, G.1    Brooks, P.C.2    Biganzoli, E.3
  • 120
    • 0031914189 scopus 로고    scopus 로고
    • Prognostic value of α6β 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells
    • Tagliabue E, Ghirelli C, Squicciarini P et al. Prognostic value of α6β4 integrin expression in breast carcinomas is affected by laminin production from tumor cells. Clin. Cancer Res. 4, 407-410 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 407-410
    • Tagliabue, E.1    Ghirelli, C.2    Squicciarini, P.3
  • 121
    • 0028813315 scopus 로고
    • High expression level of α 6 integrin in human breast carcinoma is correlated with reduced survival
    • Friedrichs Y, Ruiz P, Franke F et al. High expression level of α6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res. 55, 901-906 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 901-906
    • Friedrichs, Y.1    Ruiz, P.2    Franke, F.3
  • 122
    • 0034627152 scopus 로고    scopus 로고
    • Ep-CAM overexpression in breast cancer as a predictor of survival
    • Gastl G, Spizzo G, Obrist P et al. Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 356, 1981-1982 (2000).
    • (2000) Lancet , vol.356 , pp. 1981-1982
    • Gastl, G.1    Spizzo, G.2    Obrist, P.3
  • 123
    • 0032412620 scopus 로고    scopus 로고
    • Prognostic significance of micrometastatic bone marrow involvement
    • Braun S, Pantel K. Prognostic significance of micrometastatic bone marrow involvement. Breast Cancer Res. Treat. 52, 201-216 (1998).
    • (1998) Breast Cancer Res. Treat. , vol.52 , pp. 201-216
    • Braun, S.1    Pantel, K.2
  • 124
    • 0034812866 scopus 로고    scopus 로고
    • Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma
    • Schwartzberg LS. Clinical experience with edrecolomab: a monoclonal antibody therapy for colorectal carcinoma. Crit. Rev. Oncol. Hematol. 40, 17-24 (2001).
    • (2001) Crit. Rev. Oncol. Hematol. , vol.40 , pp. 17-24
    • Schwartzberg, L.S.1
  • 125
    • 0034991631 scopus 로고    scopus 로고
    • Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells
    • Rochefort H, Chalbos D, Cunat S et al. Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells. J. Steroid. Biochem. Mol. Biol. 76, 119-124 (2001).
    • (2001) J. Steroid. Biochem. Mol. Biol. , vol.76 , pp. 119-124
    • Rochefort, H.1    Chalbos, D.2    Cunat, S.3
  • 126
    • 0024439007 scopus 로고
    • Association between high concentration of M52,000 cathepsin D and poor prognosis in primary breast cancer
    • Thorpe SM, Rocheford H, Garcia M et al. Association between high concentration of M52,000 cathepsin D and poor prognosis in primary breast cancer. Cancer Res. 49, 6008-6014 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 6008-6014
    • Thorpe, S.M.1    Rocheford, H.2    Garcia, M.3
  • 127
    • 0025008839 scopus 로고
    • Cathepsin D and prognosis in breast cancer
    • Tandon AK, Clank GM, Chamness GC et al. Cathepsin D and prognosis in breast cancer. N. Engl. J. Med. 322, 297-302 (1990). Initial interest in cathepsin D testing faded when it became clear that the assay was only useful when performed on fresh tissue or protein extracts.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 297-302
    • Tandon, A.K.1    Clank, G.M.2    Chamness, G.C.3
  • 128
    • 0026726643 scopus 로고
    • Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays
    • Kute TE, Shao ZM, Sugg NK et al. Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays. Cancer Res. 52, 5198-5203 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 5198-5203
    • Kute, T.E.1    Shao, Z.M.2    Sugg, N.K.3
  • 129
    • 0025156864 scopus 로고
    • Prognostic significance of the estrogen regulated protein, cathepsin D, in breast cancer. An immunohistochemical study
    • Henry JA, McCarthy AI, Angus B et al. Prognostic significance of the estrogen regulated protein, cathepsin D, in breast cancer. An immunohistochemical study. Cancer 65, 265-271 (1990).
    • (1990) Cancer , vol.65 , pp. 265-271
    • Henry, J.A.1    McCarthy, A.I.2    Angus, B.3
  • 130
    • 0027597695 scopus 로고
    • Immunohistologic evaluation on invasion-associated proteases in breast carcinoma
    • Visscher DW, Sarkar F, LoRusso P et al. Immunohistologic evaluation on invasion-associated proteases in breast carcinoma. Mod. Pathol. 6, 302-306 (1993).
    • (1993) Mod. Pathol. , vol.6 , pp. 302-306
    • Visscher, D.W.1    Sarkar, F.2    LoRusso, P.3
  • 131
    • 0034793454 scopus 로고    scopus 로고
    • Recent advances in breast cancer (the 37th ASCO meeting, May 2001)
    • Mokbel K, Elkak A. Recent advances in breast cancer (the 37th ASCO meeting, May 2001). Curr. Med. Res. Opin. 17, 116-122 (2001).
    • (2001) Curr. Med. Res. Opin. , vol.17 , pp. 116-122
    • Mokbel, K.1    Elkak, A.2
  • 132
    • 0036695216 scopus 로고    scopus 로고
    • Clinical utility of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 determination in primary breast cancer tissue for individualized therapy concepts
    • Harbeck N, Schmitt M, Kates RE et al. Clinical utility of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 determination in primary breast cancer tissue for individualized therapy concepts. Clin. Breast Cancer 3, 196-200 (2002).
    • (2002) Clin. Breast Cancer , vol.3 , pp. 196-200
    • Harbeck, N.1    Schmitt, M.2    Kates, R.E.3
  • 133
    • 0037102368 scopus 로고    scopus 로고
    • Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424)
    • Harbeck N, Kates RE, Look MP et al. Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424). Cancer Res. 62, 4617-4622 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4617-4622
    • Harbeck, N.1    Kates, R.E.2    Look, M.P.3
  • 134
    • 0036329424 scopus 로고    scopus 로고
    • Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: From pilot to level 1 evidence studies
    • Duffy MJ. Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to level 1 evidence studies. Clin. Chem. 48, 1194-1197 (2002).
    • (2002) Clin. Chem. , vol.48 , pp. 1194-1197
    • Duffy, M.J.1
  • 135
    • 0037083657 scopus 로고    scopus 로고
    • Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualized therapy decisions in primary breast cancer is greatest when used in combination
    • Harbeck N, Kates RE, Schmitt M. Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualized therapy decisions in primary breast cancer is greatest when used in combination. J. Clin. Oncol. 20, 1000-1007 (2002). The plasminogen proteases are reliable and accurate prognostic factors, but are limited by their current requirement for fresh protein extracts for testing.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1000-1007
    • Harbeck, N.1    Kates, R.E.2    Schmitt, M.3
  • 136
    • 1542333510 scopus 로고    scopus 로고
    • Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease
    • Qin W, Zhu W, Wagner-Mann C. Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease. Ann. Surg. Oncol. 10, 948-953 (2003).
    • (2003) Ann. Surg. Oncol. , vol.10 , pp. 948-953
    • Qin, W.1    Zhu, W.2    Wagner-Mann, C.3
  • 137
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer 2, 161-74 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 138
    • 0036516460 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A tail of a frog that became a prince
    • Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nature Rev. Mol. Cell. Biol. 3, 207-214 (2002).
    • (2002) Nature Rev. Mol. Cell. Biol. , vol.3 , pp. 207-214
    • Brinckerhoff, C.E.1    Matrisian, L.M.2
  • 139
    • 0034176764 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Multifunctional contributors to tumor progression
    • McCawley LJ, Matrisian LM. Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol. Med. Today 6, 149-156 (2000).
    • (2000) Mol. Med. Today , vol.6 , pp. 149-156
    • McCawley, L.J.1    Matrisian, L.M.2
  • 140
    • 0031663622 scopus 로고    scopus 로고
    • Roles of the matrix metalloproteinases in mammary gland development and cancer
    • Benaud C, Dickson RB, Thompson EW. Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Res. Treat. 50, 97-116 (1998).
    • (1998) Breast Cancer Res. Treat. , vol.50 , pp. 97-116
    • Benaud, C.1    Dickson, R.B.2    Thompson, E.W.3
  • 141
    • 1542273347 scopus 로고
    • Prognostic value of the level of matrix metalloprotease-2 in the fibroblasts surrounding infiltrating ductal carcinoma of the breast
    • Porter-Jordan K, Hoyhtya M, Barnes R et al. Prognostic value of the level of matrix metalloprotease-2 in the fibroblasts surrounding infiltrating ductal carcinoma of the breast. Breast Cancer Res. Treat 23, 149 (1992).
    • (1992) Breast Cancer Res. Treat. , vol.23 , pp. 149
    • Porter-Jordan, K.1    Hoyhtya, M.2    Barnes, R.3
  • 142
    • 0032530876 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 immunoreactive protein: A marker of aggressiveness in breast carcinoma
    • Talvensaari-Mattila A, Paakko P, Hoyhtya M et al. Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer 83, 1153-1162 (1998).
    • (1998) Cancer , vol.83 , pp. 1153-1162
    • Talvensaari-Mattila, A.1    Paakko, P.2    Hoyhtya, M.3
  • 143
    • 0033490751 scopus 로고    scopus 로고
    • MMP-2 positivity and age less than 40 years increases the risk for recurrence in premenopausal patients with node-positive breast carcinoma
    • Talvensaari-Mattila A, Paakko P, Turpeenniemi-Hujanen T. MMP-2 positivity and age less than 40 years increases the risk for recurrence in premenopausal patients with node-positive breast carcinoma. Breast Cancer Res. Treat. 58, 287-293 (1999).
    • (1999) Breast Cancer Res. Treat. , vol.58 , pp. 287-293
    • Talvensaari-Mattila, A.1    Paakko, P.2    Turpeenniemi-Hujanen, T.3
  • 144
    • 0035119039 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 (MMP-2) is associated with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with anti-estrogen adjuvant therapy
    • Talvensaari-Mattila A, Paakko P, Blanco-Sequeiros G et al. Matrix metalloproteinase-2 (MMP-2) is associated with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with anti-estrogen adjuvant therapy. Breast Cancer Res. Treat. 65, 55-61 (2001).
    • (2001) Breast Cancer Res. Treat. , vol.65 , pp. 55-61
    • Talvensaari-Mattila, A.1    Paakko, P.2    Blanco-Sequeiros, G.3
  • 145
    • 0035077647 scopus 로고    scopus 로고
    • Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by northern blot analysis
    • Pacheco MM, Nishimoto IN, Mourao Neto M et al. Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by northern blot analysis. Int. J. Biol. Markers 16, 62-68 (2001).
    • (2001) Int. J. Biol. Markers , vol.16 , pp. 62-68
    • Pacheco, M.M.1    Nishimoto, I.N.2    Mourao Neto, M.3
  • 146
    • 0035362633 scopus 로고    scopus 로고
    • Overexpression of matrix-metalloproteinase-9 in human breast cancer: A potential favourable indicator in node-negative patients
    • Scorilas A, Karameris A, Arnogiannaki N et al. Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients. Br. J. Cancer 84, 1488-1496 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 1488-1496
    • Scorilas, A.1    Karameris, A.2    Arnogiannaki, N.3
  • 147
    • 0030467609 scopus 로고    scopus 로고
    • High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma
    • Chenard MP, O'Siorain L, Shering S et al. High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma. Int. J. Cancer 69, 448-451 (1996).
    • (1996) Int. J. Cancer , vol.69 , pp. 448-451
    • Chenard, M.P.1    O'Siorain, L.2    Shering, S.3
  • 148
    • 0032963210 scopus 로고    scopus 로고
    • High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer
    • McCarthy K, Maguire T, McGreal G et al. High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer. Int. J. Cancer 84, 44-48 (1999).
    • (1999) Int. J. Cancer , vol.84 , pp. 44-48
    • McCarthy, K.1    Maguire, T.2    McGreal, G.3
  • 149
    • 0030839472 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus on batimastat and marimastat
    • Rasmussen HS, McCann PP. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol. Ther. 75, 69-75 (1997).
    • (1997) Pharmacol. Ther. , vol.75 , pp. 69-75
    • Rasmussen, H.S.1    McCann, P.P.2
  • 150
    • 0032423729 scopus 로고    scopus 로고
    • Steroid hormone receptors in breast cancer management
    • Osborne CK. Steroid hormone receptors in breast cancer management. Breast Cancer Res. Treat. 51, 227-238 (1998).
    • (1998) Breast Cancer Res. Treat. , vol.51 , pp. 227-238
    • Osborne, C.K.1
  • 151
    • 0031658608 scopus 로고    scopus 로고
    • Hormonal therapy of breast cancer
    • Locker GY. Hormonal therapy of breast cancer. Cancer Treat. Rev. 24, 221-240 (1998).
    • (1998) Cancer Treat. Rev. , vol.24 , pp. 221-240
    • Locker, G.Y.1
  • 152
    • 12444326150 scopus 로고    scopus 로고
    • Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors
    • Pusztai L, Ayers M, Stec J et al. Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors. Clin. Cancer Res. 9, 2406-2415 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2406-2415
    • Pusztai, L.1    Ayers, M.2    Stec, J.3
  • 153
    • 0029381976 scopus 로고
    • Prediction of recurrence for advanced breast cancer. Traditional and contemporary pathologic and molecular markers
    • Masood S. Prediction of recurrence for advanced breast cancer. Traditional and contemporary pathologic and molecular markers. Surg. Oncol. Clin. N. Am 4, 601-632 (1995).
    • (1995) Surg. Oncol. Clin. N. Am. , vol.4 , pp. 601-632
    • Masood, S.1
  • 154
    • 0026474087 scopus 로고
    • Estrogen and progesterone detection in archival formalin-fixed paraffin embedded tissue from breast carcinoma: A comparison of immunocytochemistry with dextran coated charcoal assay
    • Wilbur DC, Willis J, Mooney RA et al. Estrogen and progesterone detection in archival formalin-fixed paraffin embedded tissue from breast carcinoma: a comparison of immunocytochemistry with dextran coated charcoal assay. Mod. Pathol. 5, 79-84 (1992).
    • (1992) Mod. Pathol. , vol.5 , pp. 79-84
    • Wilbur, D.C.1    Willis, J.2    Mooney, R.A.3
  • 155
    • 0025949343 scopus 로고
    • The value of estrogen progesterone receptor determinations in advanced breast cancer
    • Bezwoda WR, Esser JD, Dansey R et al. The value of estrogen progesterone receptor determinations in advanced breast cancer. Cancer 68, 867-872 (1991).
    • (1991) Cancer , vol.68 , pp. 867-872
    • Bezwoda, W.R.1    Esser, J.D.2    Dansey, R.3
  • 156
    • 0030008295 scopus 로고    scopus 로고
    • The role of the estrogen receptor in tumor progression
    • Lemieux P, Fuqua S. The role of the estrogen receptor in tumor progression. J. Steroid Biochem. Mol. Biol. 56, 87-91 (1996).
    • (1996) J. Steroid Biochem. Mol. Biol. , vol.56 , pp. 87-91
    • Lemieux, P.1    Fuqua, S.2
  • 158
    • 0033834513 scopus 로고    scopus 로고
    • Molecular markers for predicting response to tamoxifen in breast cancer patients
    • Ciocca DF, Elledge R. Molecular markers for predicting response to tamoxifen in breast cancer patients. Endocrine 13, 1-10 (2000).
    • (2000) Endocrine , vol.13 , pp. 1-10
    • Ciocca, D.F.1    Elledge, R.2
  • 159
    • 0033493954 scopus 로고    scopus 로고
    • The evolving role of specific estrogen receptor modulators (SERMs)
    • Ibrahim NK, Hortobagyi GN. The evolving role of specific estrogen receptor modulators (SERMs). Surg. Oncol. 8(2), 103-123 (1999).
    • (1999) Surg. Oncol. , vol.8 , Issue.2 , pp. 103-123
    • Ibrahim, N.K.1    Hortobagyi, G.N.2
  • 161
    • 0036839717 scopus 로고    scopus 로고
    • An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole and exemestane
    • Buzdar AU, Robertson JF, Eiermann W et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole and exemestane. Cancer 95, 2006-20016 (2002).
    • (2002) Cancer , vol.95 , pp. 2006-20016
    • Buzdar, A.U.1    Robertson, J.F.2    Eiermann, W.3
  • 162
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a Phase III randomized trial
    • Ellis MJ, Coop A, Singh B et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a Phase III randomized trial. J. Clin. Oncol. 19, 3808-3816 (2001). The concept that HER-2/neu status can predict response to specific antiestrogen therapy is considered.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 163
    • 0035576786 scopus 로고    scopus 로고
    • HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer
    • Dowsett M, Harper-Wynne C, Boeddinghaus I et al. HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer. Cancer Res. 61, 8452-8458 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8452-8458
    • Dowsett, M.1    Harper-Wynne, C.2    Boeddinghaus, I.3
  • 164
    • 0027186436 scopus 로고
    • Multi-drug resistance phenotype: A potential marker of chemotherapy resistance in breast cancer
    • Decker DA, Morris LW, Levine AJ et al. Multi-drug resistance phenotype: a potential marker of chemotherapy resistance in breast cancer. Lab. Med. 24, 574-578 (1993).
    • (1993) Lab. Med. , vol.24 , pp. 574-578
    • Decker, D.A.1    Morris, L.W.2    Levine, A.J.3
  • 165
    • 0030751798 scopus 로고    scopus 로고
    • mdR1 mRNA expression by RT-PCR in patients with primary breast cancer submitted to neoadjuvant therapy
    • Wang CS, LaRue H, Fortin A et al. mdR1 mRNA expression by RT-PCR in patients with primary breast cancer submitted to neoadjuvant therapy. Breast Cancer Res. Treat. 45, 63-74 (1997).
    • (1997) Breast Cancer Res. Treat. , vol.45 , pp. 63-74
    • Wang, C.S.1    LaRue, H.2    Fortin, A.3
  • 166
    • 0030920342 scopus 로고    scopus 로고
    • Multi-drug resistance in breast cancer: A meta-analysis of MDR1/gp 170 expression and its possible functional significance
    • Trock BJ, Leonessa F, Clarke R. Multi-drug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance. J. Natl Cancer Inst. 89, 917-931 (1997).
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 917-931
    • Trock, B.J.1    Leonessa, F.2    Clarke, R.3
  • 167
    • 0023037085 scopus 로고
    • Overexpression of a novel and an ionic glutathionic transferase in multi-drug-resistant human breast cancer cells
    • Batiste G, Tulpule A, Shinha BK et al. Overexpression of a novel and an ionic glutathionic transferase in multi-drug-resistant human breast cancer cells. J. Biol. Chem. 261, 15554-15549 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 15554-15549
    • Batiste, G.1    Tulpule, A.2    Shinha, B.K.3
  • 168
    • 0026610140 scopus 로고
    • Expression of MDR1 and gluthathione s-transferase genes and chemosensitivities in human gastrointestinal cancer
    • Satta T, Isobe K, Yamauchi M et al. Expression of MDR1 and gluthathione s-transferase genes and chemosensitivities in human gastrointestinal cancer. Cancer 69, 941-946 (1992).
    • (1992) Cancer , vol.69 , pp. 941-946
    • Satta, T.1    Isobe, K.2    Yamauchi, M.3
  • 169
    • 0030810242 scopus 로고    scopus 로고
    • Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: Inconsistency with their established prognostic significance
    • Ardavanis A, Gerakini F, Amanatidou A et al. Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: inconsistency with their established prognostic significance. Anticancer Res. 17, 3665-3669 (1997).
    • (1997) Anticancer Res. , vol.17 , pp. 3665-3669
    • Ardavanis, A.1    Gerakini, F.2    Amanatidou, A.3
  • 170
    • 0031819577 scopus 로고    scopus 로고
    • Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen
    • Dittadi R, Biganzoli E, Boracchi P et al. Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen. Int. J. Biol. Markers 13, 30-41 (1998).
    • (1998) Int. J. Biol. Markers , vol.13 , pp. 30-41
    • Dittadi, R.1    Biganzoli, E.2    Boracchi, P.3
  • 172
    • 0344761136 scopus 로고
    • Estrogen-inducible heat shock protein hsp27 predicts recurrence in node-negative breast cancer
    • Chamness GC. Estrogen-inducible heat shock protein hsp27 predicts recurrence in node-negative breast cancer. Proc. Am. Assoc. Cancer Res. 30, 252 (1989).
    • (1989) Proc. Am. Assoc. Cancer Res. , vol.30 , pp. 252
    • Chamness, G.C.1
  • 173
    • 0027503365 scopus 로고
    • Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: Prognostic implications
    • Ciocca DR, Clark GM, Tandon AK et al. Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst. 85, 570-574 (1993).
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 570-574
    • Ciocca, D.R.1    Clark, G.M.2    Tandon, A.K.3
  • 174
    • 0029071818 scopus 로고
    • Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: An immunohistochemical study
    • Tetu B, Brisson J, Landry J et al. Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: an immunohistochemical study. Breast Cancer Res. Treat. 36, 93-97 (1995).
    • (1995) Breast Cancer Res. Treat. , vol.36 , pp. 93-97
    • Tetu, B.1    Brisson, J.2    Landry, J.3
  • 175
    • 0029951848 scopus 로고    scopus 로고
    • The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients
    • Oesterreich S, Hilsenbeck SG, Ciocca DR et al. The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients. Clin Cancer Res. 2, 1199-1206 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1199-1206
    • Oesterreich, S.1    Hilsenbeck, S.G.2    Ciocca, D.R.3
  • 176
    • 0035938960 scopus 로고    scopus 로고
    • Studies of apoptosis in breast cancer
    • Parton M, Dowsert M, Smith I. Studies of apoptosis in breast cancer. Br. Med. J. 322, 1528-1532 (2001).
    • (2001) Br. Med. J. , vol.322 , pp. 1528-1532
    • Parton, M.1    Dowsert, M.2    Smith, I.3
  • 177
    • 0032055936 scopus 로고    scopus 로고
    • bcl-2 and apoptosis in lymph node positive breast carcinoma
    • Berardo MD, Elledge RM, de Moor C et al. bcl-2 and apoptosis in lymph node positive breast carcinoma. Cancer 82, 1296-1302 (1998).
    • (1998) Cancer , vol.82 , pp. 1296-1302
    • Berardo, M.D.1    Elledge, R.M.2    De Moor, C.3
  • 178
    • 0031927561 scopus 로고    scopus 로고
    • Apoptotic index correlates to Bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers
    • Zhang GJ, Kimijima I, Abe R et al. Apoptotic index correlates to Bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers. Anticancer Res. 18, 1989-1998 (1998).
    • (1998) Anticancer Res. , vol.18 , pp. 1989-1998
    • Zhang, G.J.1    Kimijima, I.2    Abe, R.3
  • 179
    • 0033967844 scopus 로고    scopus 로고
    • Number of apoptotic cells as a prognostic marker in invasive breast cancer
    • De Jong JS, van Diest PJ, Baak JP. Number of apoptotic cells as a prognostic marker in invasive breast cancer. Br. J. Cancer 82, 368-373 (2000).
    • (2000) Br. J. Cancer , vol.82 , pp. 368-373
    • De Jong, J.S.1    Van Diest, P.J.2    Baak, J.P.3
  • 181
    • 0032943691 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis regulators in breast cancer
    • Krajewski S, Krajewska M, Turner BC et al. Prognostic significance of apoptosis regulators in breast cancer. Endocr. Relat. Cancer 6, 29-40 (1999).
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 29-40
    • Krajewski, S.1    Krajewska, M.2    Turner, B.C.3
  • 182
    • 1242312439 scopus 로고    scopus 로고
    • Prognostic value of Bcl-2 in invasive breast cancer receiving chemotherapy and endocrine therapy
    • Yang Q, Sakurai T, Yoshimura G et al. Prognostic value of Bcl-2 in invasive breast cancer receiving chemotherapy and endocrine therapy. Oncol. Rep. 10, 121-125 (2003).
    • (2003) Oncol. Rep. , vol.10 , pp. 121-125
    • Yang, Q.1    Sakurai, T.2    Yoshimura, G.3
  • 184
    • 0032881750 scopus 로고    scopus 로고
    • Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion
    • Vakkala M, Paakko P, Soini Y. Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br. J. Cancer 81, 592-599 (1999).
    • (1999) Br. J. Cancer , vol.81 , pp. 592-599
    • Vakkala, M.1    Paakko, P.2    Soini, Y.3
  • 185
    • 0035744678 scopus 로고    scopus 로고
    • Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer
    • Nakopoulou L, Alexandrou P, Stefanaki K et al. Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer. Pathobiology 69, 266-273 (2001).
    • (2001) Pathobiology , vol.69 , pp. 266-273
    • Nakopoulou, L.1    Alexandrou, P.2    Stefanaki, K.3
  • 186
    • 0037069938 scopus 로고    scopus 로고
    • Downregulation of caspase 3 in breast cancer: A possible mechanism for chemoresistance
    • Devarajan E, Sahin AA, Chen JS et al. Downregulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 21, 8843-8851 (2002).
    • (2002) Oncogene , vol.21 , pp. 8843-8851
    • Devarajan, E.1    Sahin, A.A.2    Chen, J.S.3
  • 187
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB IκB proteins: New discoveries and insights
    • Baldwin AS. The NF-κB and IκB proteins: new discoveries and insights. Ann. Rev. Immunol. 14, 649-683 (1996).
    • (1996) Ann. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 188
    • 0036020941 scopus 로고    scopus 로고
    • NF-κB as a therapeutic target in cancer
    • Orlowski RZ, Baldwin AS. NF-κB as a therapeutic target in cancer. Trends Mol. Med. 8(8), 385-389 (2002).
    • (2002) Trends Mol. Med. , vol.8 , Issue.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin, A.S.2
  • 189
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer from innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR et al. NF-κB in cancer from innocent bystander to major culprit. Nature Rev. Cancer 2, 301-310, (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3
  • 190
    • 0036680037 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancer
    • Adams J. Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancer. Curr. Opin. Chem. Biol. 6, 493-500 (2002).
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 493-500
    • Adams, J.1
  • 191
    • 0035964203 scopus 로고    scopus 로고
    • The nuclear factor κB (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers
    • Biswas DK, Dai SC, Cruz A et al. The nuclear factor κB (NF-κB): a potential therapeutic target for estrogen receptor negative breast cancers. Proc. Natl Acad. Sci. USA 98, 10386-10391 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10386-10391
    • Biswas, D.K.1    Dai, S.C.2    Cruz, A.3
  • 192
    • 0037028211 scopus 로고    scopus 로고
    • Expression of the transcription factor Ets-1 is an independent prognostic marker market for relapse-free survival in breast cancer
    • Span PN, Manders P, Heuvel JJ et al. Expression of the transcription factor Ets-1 is an independent prognostic marker market for relapse-free survival in breast cancer. Oncogene 21, 8506-8509 (2002).
    • (2002) Oncogene , vol.21 , pp. 8506-8509
    • Span, P.N.1    Manders, P.2    Heuvel, J.J.3
  • 193
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson M, Dejmek J, Bendahl PO et al. Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res. 62, 409-416 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.O.3
  • 195
    • 0032887083 scopus 로고    scopus 로고
    • Telomerase activity and prognosis in primary breast cancers
    • Carey LA, Kim NW, Goodman S et al. Telomerase activity and prognosis in primary breast cancers. J. Clin. Oncol. 17, 3075-3081 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3075-3081
    • Carey, L.A.1    Kim, N.W.2    Goodman, S.3
  • 196
    • 0033151703 scopus 로고    scopus 로고
    • Telomerase activity and prognosis in breast cancer
    • Mokbel K, Parris CN, Radbourne R et al. Telomerase activity and prognosis in breast cancer. Eur. J. Surg. Oncol. 25, 269-272 (1999).
    • (1999) Eur. J. Surg. Oncol. , vol.25 , pp. 269-272
    • Mokbel, K.1    Parris, C.N.2    Radbourne, R.3
  • 197
    • 0036479770 scopus 로고    scopus 로고
    • Telomerase activity in microdissected human breast cancer tissues: Association with p53, p21 and outcome
    • Mueller C, Riese U, Kosmehl H et al. Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome. Int. J. Oncol. 20, 385-390 (2002).
    • (2002) Int. J. Oncol. , vol.20 , pp. 385-390
    • Mueller, C.1    Riese, U.2    Kosmehl, H.3
  • 198
    • 0343415646 scopus 로고    scopus 로고
    • Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay
    • Bieche I, Nogues C, Paradis V et al. Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res. 6, 452-429 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 452-429
    • Bieche, I.1    Nogues, C.2    Paradis, V.3
  • 199
    • 0036772604 scopus 로고    scopus 로고
    • Telomerase as a prognostic marker in breast cancer high-throughput tissue microarray analysis of hTERT and hTR
    • Poremba C, Heine B, Diallo R et al. Telomerase as a prognostic marker in breast cancer high-throughput tissue microarray analysis of hTERT and hTR. J. Pathol. 198, 181-189 (2002).
    • (2002) J. Pathol. , vol.198 , pp. 181-189
    • Poremba, C.1    Heine, B.2    Diallo, R.3
  • 201
    • 0036393684 scopus 로고    scopus 로고
    • Microsatellite instability in early-onset breast cancer
    • Ozer E, Yuksel E, Kizildag S et al. Microsatellite instability in early-onset breast cancer. Pathol. Res. Pract. 198, 525-530 (2002).
    • (2002) Pathol. Res. Pract. , vol.198 , pp. 525-530
    • Ozer, E.1    Yuksel, E.2    Kizildag, S.3
  • 202
    • 0032974195 scopus 로고    scopus 로고
    • Analyses of microsatellite instability and the transforming growth factor-β receptor Type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features
    • Tomita S, Deguchi S, Miyaguni T et al. Analyses of microsatellite instability and the transforming growth factor-β receptor Type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features. Breast Cancer Res. Treat. 53, 33-39 (1999).
    • (1999) Breast Cancer Res. Treat. , vol.53 , pp. 33-39
    • Tomita, S.1    Deguchi, S.2    Miyaguni, T.3
  • 203
    • 0037068360 scopus 로고    scopus 로고
    • DNA methylation and breast carcinogenesis
    • Widschwendter M, Jones PA. DNA methylation and breast carcinogenesis. Oncogene 21, 5462-5482 (2002).
    • (2002) Oncogene , vol.21 , pp. 5462-5482
    • Widschwendter, M.1    Jones, P.A.2
  • 205
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (ER)-α by DNA methyltransferase and histone deacetylase inhibition in human ER-α-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT et al. Synergistic activation of functional estrogen receptor (ER)-α by DNA methyltransferase and histone deacetylase inhibition in human ER-α-negative breast cancer cells. Cancer Res. 61, 7025-7029 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3
  • 206
    • 0034688926 scopus 로고    scopus 로고
    • Comparison of the metastasis-inducing protein S 100A4 (p9ka) with other prognostic markers in human breast cancer
    • Platt-Higgins AM, Renshaw CA, West CR et al. Comparison of the metastasis-inducing protein S 100A4 (p9ka) with other prognostic markers in human breast cancer. Int. J. Cancer 89, 198-208 (2000).
    • (2000) Int. J. Cancer , vol.89 , pp. 198-208
    • Platt-Higgins, A.M.1    Renshaw, C.A.2    West, C.R.3
  • 207
    • 0035463854 scopus 로고    scopus 로고
    • Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors
    • Xu Y, Kimura N, Yoshida R et al. Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: relationship with prognostic factors. Oncol. Rep. 8, 1177-1182 (2001).
    • (2001) Oncol. Rep. , vol.8 , pp. 1177-1182
    • Xu, Y.1    Kimura, N.2    Yoshida, R.3
  • 208
    • 0036468899 scopus 로고    scopus 로고
    • Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer
    • Ristimaki A, Sivula A, Lundin J et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res. 62, 632-635 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 632-635
    • Ristimaki, A.1    Sivula, A.2    Lundin, J.3
  • 209
    • 0035998299 scopus 로고    scopus 로고
    • Nuclear matrix proteins as biomarkers for breast cancer
    • Luftner D, Possinger K. Nuclear matrix proteins as biomarkers for breast cancer. Expert Rev. Mol. Diagn. 2, 23-31 (2002).
    • (2002) Expert Rev. Mol. Diagn. , vol.2 , pp. 23-31
    • Luftner, D.1    Possinger, K.2
  • 210
    • 12644276375 scopus 로고    scopus 로고
    • A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
    • Chen YT, Scanlan MJ, Sahin U et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc. Natl Acad. Sci. USA 94, 1914-1918 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1914-1918
    • Chen, Y.T.1    Scanlan, M.J.2    Sahin, U.3
  • 211
    • 0034891460 scopus 로고    scopus 로고
    • Expression of MAGE tumour-associated antigens is inversely correlated with tumour differentiation in invasive ductal breast cancers: An immunohistochemical study
    • Kayalar R, Sarcevic B, Spagnoli GC et al. Expression of MAGE tumour-associated antigens is inversely correlated with tumour differentiation in invasive ductal breast cancers: an immunohistochemical study. Virchows Arch. 439, 127-131 (2001).
    • (2001) Virchows Arch. , vol.439 , pp. 127-131
    • Kayalar, R.1    Sarcevic, B.2    Spagnoli, G.C.3
  • 212
    • 0035884426 scopus 로고    scopus 로고
    • MAGE-A gene expression pattern in primary breast cancer
    • Otte M, Zafrakas M, Riethdorf L et al. MAGE-A gene expression pattern in primary breast cancer. Cancer Res. 61, 6682-6687 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6682-6687
    • Otte, M.1    Zafrakas, M.2    Riethdorf, L.3
  • 213
    • 0035107378 scopus 로고    scopus 로고
    • Molecular strategy for detecting metastatic cancers with use of multiple tumor-specific MAGE-A genes
    • Miyashiro I, Kuo C, Huynh K et al. Molecular strategy for detecting metastatic cancers with use of multiple tumor-specific MAGE-A genes. Clin. Chem. 47, 505-512 (2001).
    • (2001) Clin. Chem. , vol.47 , pp. 505-512
    • Miyashiro, I.1    Kuo, C.2    Huynh, K.3
  • 214
    • 0034642307 scopus 로고    scopus 로고
    • Gene expression profiling of primary breast carcinomas using arrays of candidate genes
    • Bertucci F, Houlgatte R, Benziane A et al. Gene expression profiling of primary breast carcinomas using arrays of candidate genes. Hum. Mol. Genet. 9, 2981-2991 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2981-2991
    • Bertucci, F.1    Houlgatte, R.2    Benziane, A.3
  • 215
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad Sci. USA 98, 10869-10874 (2001). Initial discovery study of gene expression and breast cancer biology.
    • (2001) Proc. Natl. Acad Sci. USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 216
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van 't Veer LJ, Dai H, van de Vijver MJ et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002). Transcriptional profiting of breast cancers with long-term follow-up links patterns of gene expression with overall and disease-free survival.
    • (2002) Nature , vol.415 , pp. 530-536
    • Van't Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3
  • 217
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002). Further details and expansion of data of clinical outcome study.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1999-2009
    • Van De Vijver, M.J.1    He, Y.D.2    Van't Veer, L.J.3
  • 218
    • 0035949684 scopus 로고    scopus 로고
    • Predicting the clinical status of human breast cancer by using gene expression profiles
    • West M, Blanchette C, Dressman H et al. Predicting the clinical status of human breast cancer by using gene expression profiles. Proc. Natl Acad. Sci. USA 98, 11462-11467 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11462-11467
    • West, M.1    Blanchette, C.2    Dressman, H.3
  • 219
    • 0141994853 scopus 로고    scopus 로고
    • Towards integrated clinico-genomic models for personalized medicine combining gene expression signatures and clinical factors in breast cancer outcomes prediction
    • Nevins JR, Huang ES, Dressman H et al. Towards integrated clinico-genomic models for personalized medicine combining gene expression signatures and clinical factors in breast cancer outcomes prediction. Hum. Mol. Genet. 12, 153-157 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 153-157
    • Nevins, J.R.1    Huang, E.S.2    Dressman, H.3
  • 220
    • 0042838307 scopus 로고    scopus 로고
    • Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    • Sotiriou C, Neo SY, McShane LM et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc. Natl Acad. Sci. USA 100, 10393-10398 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10393-10398
    • Sotiriou, C.1    Neo, S.Y.2    McShane, L.M.3
  • 221
    • 0242405575 scopus 로고    scopus 로고
    • Advantages and limitations of microarray technology in human cancer
    • Russo G, Zegar C, Giordano A. Advantages and limitations of microarray technology in human cancer. Oncogene 22, 6497-6507 (2003).
    • (2003) Oncogene , vol.22 , pp. 6497-6507
    • Russo, G.1    Zegar, C.2    Giordano, A.3
  • 222
    • 0038244058 scopus 로고    scopus 로고
    • Gene expression predictors of breast cancer outcomes
    • Huang E, Cheng SH, Dressman H et al. Gene expression predictors of breast cancer outcomes. Lancet 361, 1590-1596 (2003).
    • (2003) Lancet , vol.361 , pp. 1590-1596
    • Huang, E.1    Cheng, S.H.2    Dressman, H.3
  • 223
    • 0037116832 scopus 로고    scopus 로고
    • Use of proteomic patterns in serum to identify ovarian cancer
    • Petricoin EF, Ardekani AM, Hitt BA et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 359, 572-577 (2002). Can barcode surface-enhanced laser desorption ionization-based proteomics with neural network data analysis detect occult cancer in serum far earlier than currently available cancer detection methods?
    • (2002) Lancet , vol.359 , pp. 572-577
    • Petricoin, E.F.1    Ardekani, A.M.2    Hitt, B.A.3
  • 224
    • 0036324715 scopus 로고    scopus 로고
    • Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer
    • Li J, Zhang Z, Rosenzweig J et al. Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin. Chem. 48, 1296-1304 (2002).
    • (2002) Clin. Chem. , vol.48 , pp. 1296-1304
    • Li, J.1    Zhang, Z.2    Rosenzweig, J.3
  • 225
    • 0034762644 scopus 로고    scopus 로고
    • Using genetic variation to study human disease
    • Taylor JG. Using genetic variation to study human disease. Trends Mol. Med. 7, 507-512 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 507-512
    • Taylor, J.G.1
  • 227
    • 0035479620 scopus 로고    scopus 로고
    • Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes
    • Ingdman-Sundberg M. Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes. Mutat. Res. 482, 11-19 (2001).
    • (2001) Mutat. Res. , vol.482 , pp. 11-19
    • Ingdman-Sundberg, M.1
  • 228
    • 0036202663 scopus 로고    scopus 로고
    • Update on pharmacogenetics in cancer chemotherapy
    • Innocenti F, Ratain MJ. Update on pharmacogenetics in cancer chemotherapy. Eur. J. Cancer 38, 639-644 (2002).
    • (2002) Eur. J. Cancer , vol.38 , pp. 639-644
    • Innocenti, F.1    Ratain, M.J.2
  • 229
    • 0035474758 scopus 로고    scopus 로고
    • Pharmacogenetics
    • Roses AD. Pharmacogenetics. Hum. Mol. Genet. 10, 2261-2267 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2261-2267
    • Roses, A.D.1
  • 230
  • 231
    • 19244381642 scopus 로고    scopus 로고
    • Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer
    • Nishimura R, Nagao K, Miyayama H et al. Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer. Anticancer Res. 19, 5621-5626 (1999).
    • (1999) Anticancer Res. , vol.19 , pp. 5621-5626
    • Nishimura, R.1    Nagao, K.2    Miyayama, H.3
  • 232
    • 0034626986 scopus 로고    scopus 로고
    • Pharmacogenomics: Teaching old drugs new tricks
    • Weinstein JN. Pharmacogenomics: teaching old drugs new tricks. N. Engl. J. Med. 343, 1408-1409 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1408-1409
    • Weinstein, J.N.1
  • 233
    • 0035020425 scopus 로고    scopus 로고
    • Transcriptional profiling in cancer the path to clinical pharmacogenomics
    • Slonim DK. Transcriptional profiling in cancer the path to clinical pharmacogenomics. Pharmacogenomics 2, 123-136 (2001).
    • (2001) Pharmacogenomics , vol.2 , pp. 123-136
    • Slonim, D.K.1
  • 234
    • 1542333509 scopus 로고    scopus 로고
    • Gene expression profiling of fine needle aspirations of breast cancer identifies genes associated with complete pathologic response to neoadjuvant taxol/FAC chemotherapy
    • In Press
    • Ayers M, Symmans WF, Stec J et al. Gene expression profiling of fine needle aspirations of breast cancer identifies genes associated with complete pathologic response to neoadjuvant taxol/FAC chemotherapy. J. Clin. Oncol. (2004) (In Press). First demonstration of the use of transcriptional profiling to predict the response to multiagent breast cancer chemotherapy in the neoadjuvant setting using pathologic complete response as the study end point.
    • (2004) J. Clin. Oncol.
    • Ayers, M.1    Symmans, W.F.2    Stec, J.3
  • 235
    • 0042125511 scopus 로고    scopus 로고
    • Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer
    • Chang JC, Wooten EC, Tsimelzon et al. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet 362, 362-369 (2003).
    • (2003) Lancet , vol.362 , pp. 362-369
    • Chang, J.C.1    Wooten, E.C.2    Tsimelzon3
  • 236
    • 0141725730 scopus 로고    scopus 로고
    • Mode of action of docetaxel - A basis for combination with novel anticancer agents
    • Herbst RS, Khuri FR. Mode of action of docetaxel - a basis for combination with novel anticancer agents. Cancer Treat. Rev. 29(5), 407-415 (2003).
    • (2003) Cancer Treat. Rev. , vol.29 , Issue.5 , pp. 407-415
    • Herbst, R.S.1    Khuri, F.R.2


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