Reduced E-cadherin immunohistochemical expression in node-negative breast carcinomas correlates with 10-year survival

American Journal of Clinical Pathology

Volumn 109, Issue 4, 1998, Pages 431-438

  Charpin, Colette ^a,b   Garcia, Stéphane ^b   Bonnier, Pascal ^b   Martini, François ^b   Andrac, Lucile ^a   Choux, Régine ^a   Lavaut, Marie Noëlle ^a   Allasia, Claude ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b HÔPITAL NORD   (France)

Author keywords

Breast carcinoma; E cadherin; Image analysis; Immunohistochemistry; Prognosis

Indexed keywords

UVOMORULIN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; COMPUTER ASSISTED DIAGNOSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

EID: 0031948671     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/109.4.431     Document Type: Article

References (10)

1. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991;251:1451-1455.
2. Behrens J, Marcel MM, Von Roy FM, et al. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol. 1989;108:2435-2447.
3. Shimoyana Y, Hisrohashi S. Cadherin intercellular adhesion molecule in hepato-cellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett. 1991;57:131-135.
4. Shimoyana Y, Hirohashi S. Expression of E- and P-cadherin in gastric carcinomas. Cancer Res. 1991;51:2185-2192.
5. Mayer B, Johnson JP, Leitl F, et al. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res. 1993;53:1690-1695.
6. Becker KF, Atkinson MJ, Reich U, et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 1994;54:3845-3852.
7. Kadowaki T, Shiozaki H, Inoue M, et al. E-cadherin and α-catenin expression in human esophageal cancer. Cancer Res. 1994;54:291-296.
8. Kinsella AR, Green B, Lepts GC, et al. The role of the cell adhesion molecule E-cadherin in large bowel tumor cell invasion and metastasis. Br J Cancer. 1993;67:904-909.
9. Umbas R, Isaacs WB, Bringuier PP, et al. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 1994;54:3929-3933.
10. Brabant G, Hoang-Vu C, Cetin Y, et al. E-cadherin: a differentiation marker in thyroid malignancies. Cancer Res. 1994;53:4987-1993.