p53 protein expression in human breast carcinoma: Lack of prognostic potential for recurrence of the disease

Anticancer Research

Volumn 16, Issue 3 A, 1996, Pages 1301-1304

  Katoh, Arthur ^a   Breier, Sherri ^a   Stemmler, Nancy ^a   Specht, Susan ^a   Blanock, Kurt ^a   D'Amico, Frank ^b  

^a MERCY HOSPITAL OF PITTSBURGH   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

Breast cancer; Immunohistochemistry; p53; Recurrence

Indexed keywords

ESTROGEN RECEPTOR; FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; PROGESTERONE RECEPTOR; PROTEIN P53;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; FEMALE; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OBESITY; PROGNOSIS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; STAINING AND LABELING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029901997     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Hortobagyi GN and Buzdar AU: Current Status of adjuvant systemic therapy for primary breast cancer: progress and controversy. CA Cancer J Clin 45: 199-226, 1995
2. Marx J: How p53 suppresses cell growth. Science 262: 1644-1645, 1993.
3. Levine AJ, Momand J and Finlay CA: The p53 tumour suppressor gene. Nature 351: 453-456, 1991
4. Hollstein M, Sidransky D, Vogelstein B and Harris, CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
5. Elledge RM and Allred DC: The p53 tumor suppressor gene in breast cancer. Breast Cancer Res and Treat 32: 39-47, 1994.
6. Fung CY and Fisher DE: p53: From molecular mechanisms to prognosis in cancer. J Clin Oncol 13: 808-811, 1995.
7. Greenblatt MS, Bennett WP, Hollstein M and Harris CC: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878, 1994.
8. Poller DN, Hutchings CE, Galea M, Bell JA, Nicholson RA, Elston CW, Blarney RW and Ellis IO: p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor. Br J Cancer 66: 583-588, 1992.
9. Charpin C, DeVictor B, Andrac L, Amabile J, Bergeret D, La Vaut M-N, Allasia C and Piana L: p53 quantitative immunocytochemical analysis in breast carcinomas. Human Path 26: 159-166, 1995.
10. Shi S-R. Gu J, Kalra KL, Chen T, Cote RJ and Taylor CR: Antigen retrieval technique: a novel approach to immunohistochemistry on routinely processed tissue sections. Cell Vision 2: 6-22, 1995.
11. Katoh A, Watzlaf VJM and D'Amico, F: An examination of obesity and breast cancer survival in post-menopausal women. Br J Cancer 70: 928-933, 1994.
12. Hopkins B: Assessment of nutritional status. In: Shronts EP (ed). Nutrition Support Dietetics. Core Curriculum 1989-90. Silver Spring, Amer Assoc Parenteral and Enteral Nutrition 1989. pp. 15-62.
13. Thor AD, Moore DH II, Edgerton SM, Kawasaki ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen L-C, Mayall BH and Smith HS: Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Nat Cancer Inst 84: 845-855, 1992
14. Isola J, Visakorpi T, Holli K and Kallioniemi O-P: Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node negative breast cancer patients J Nat Cancer Inst 84: 1109-1114, 1992.
15. Hurlimann J: Prognostic value of p53 protein expression in breast carcinomas. Path Res Pract 189: 996-1003, 1993.
16. Barnes DM, Dublin EA, Fisher CJ, Levison DA and Millis RR: Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis? Human Path 24: 469-476, 1993
17. Friedrichs K, Gluba S, Eidtmann H and Jonat W: Overexpression of p53 and prognosis in breast cancer. Cancer 72: 3641-3647, 1993.
18. Poller DN, Roberts EC, Bell JA, Elston CW, Blarney RW and Ellis IO: p53 protein expression in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein. Human Path 24: 463-468, 1993.
19. Haerslev T and Jacobsen GK: An immunohistochemical study of p53 with correlations to histopathological parameters, c-erbB-2. proliferating cell nuclear antigen, and prognosis. Human Path 26: 295-301, 1995.
20. Allred DC, Clark GM, Elledge R, Fuqua SAW, Brown RW, Chamness GC, Osborne CK and McGuire WL: Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Nat Cancer Inst 85: 200-206, 1993.
21. Borg A, Lenncrstrand J, Stenmark-Askmalm M, Ferno M, Brisfors A, Ohrvik A, Stal O, Killander D, Lane D and Brundell J: Prognostic significance of p53 Overexpression in primary breast cancer: a novel luminometric immunoassay applicable on steroid receptor cytosok Br J Cancer 71: 1013-1017, 1995.
22. Gaspanni G, Bevilacqua P, Boracchi P, Maluta S, Pozza F, Barbareschi M, Palma PD, Mezzetti M and Harris AL: Prognostic value of p53 expression in early-stage breast carcinoma compared with tumour angiogenesis, epidermal growth factor receptor, c-erbB-2, cathepsin D, DNA ploidy, parameters of cell kinetics and conventional features. Int J Oncol 4: 155-162, 1994.
23. Silvestrini R, Benini E, Daidone MG, Vencroni S, Boracchi P, Cappelletti V, Di Fronzo G and Veronesi U: p53 as an independent prognostic marker in lymph node-negative breast cancer patients. J Nat Cancer Inst 85: 965-970, 1993.
24. Rosen PP, Lesser ML, Arroyo CD, Cranor M, Borgen P and Norton L: p53 in node-negative breast carcinoma, an immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis. J Clin Oncol 13, 821-830, 1995.
25. Hanzal E, Gitsch G, Kohiberger P, Dadak C, Miechowiecka N and Breitenecker G Immunohistochemical detection of mutant p53-suppressor gene product in patients with breast cancer: influence on metastasis-free survival. Anticancer Res 12: 2325-2330, 1992
26. Mazars R, Spinardi L, BenCheikh M, Simony-Lafontaine J, Jeanteur P and Theillet C: p53 mutations occur in aggressive breast cancer. Cancer Res 52: 3918-3923, 1992.
27. Sirvent JJ, Salvado MT, Santafe M, Brunet J, Alvaro T and Palacios J: p53 in breast cancer. Its relation to histological grade, lymph-node status, hormone receptors, cell-proliferation fraction (ki-67) and c-erhB-2. Immunohistochemical study of 153 cases. Histol Histo Pathol 10: 531-539, 1995.