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Volumn 1, Issue 2, 2001, Pages 99-108

Pharmacogenetics and cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CYTOCHROME P450; DRUG RECEPTOR; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METHYLTRANSFERASE; THIOPURINE METHYLTRANSFERASE; TRANSFERASE;

EID: 0035524458     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/35101056     Document Type: Article
Times cited : (219)

References (24)
  • 1
    • 0035105588 scopus 로고    scopus 로고
    • Gazing into a crystal ball - Cancer therapy in the post-genomic era
    • Ratain, M. J. & Relling, M. V. Gazing into a crystal ball - cancer therapy in the post-genomic era. Nature Med. 7, 283-285 (2001).
    • (2001) Nature Med. , vol.7 , pp. 283-285
    • Ratain, M.J.1    Relling, M.V.2
  • 2
    • 0032611040 scopus 로고    scopus 로고
    • Cancer, genomics, and the national cancer institute
    • Klausner, R. D. Cancer, genomics, and the National Cancer Institute. J. Clin. Invest. 104, 15-17 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 15-17
    • Klausner, R.D.1
  • 4
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans, W. E. & Relling, M. V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez, F. J. et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331, 442-446 (1988). The genetic basis underlying individual variations in responses to the antihypertensive drug debrisoquine. Poor drug metabolizers were found to express negligible amounts of the cytochrome P450 enzyme P450db1. The authors cloned the human P450db1 cDNA and purified the protein, discovering one of the most commonly occuring mutations. This was the start of modern pharmacogenetics.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1
  • 7
    • 0025103215 scopus 로고
    • Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: Relationship to the presence of immunoidentified cytochrome P-450IID1
    • Mortimer, O. et al. Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1. Clin. Pharmacol. Ther. 47, 27-35 (1990).
    • (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 27-35
    • Mortimer, O.1
  • 8
    • 0025259226 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms
    • Meyer, U. A. The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms. Pharmacol. Ther. 46, 297-308 (1990).
    • (1990) Pharmacol. Ther. , vol.46 , pp. 297-308
    • Meyer, U.A.1
  • 9
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer, U. A. & Zanger, U. M. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 10
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson, I. et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl Acad. Sci. USA 90, 11825-11829 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 11825-11829
    • Johansson, I.1
  • 11
    • 0035865322 scopus 로고    scopus 로고
    • A map of human genome sequence variation containing 1.42 million single nucleotids polymorphisms
    • Sachidanandam, R. et al. A map of human genome sequence variation containing 1.42 million single nucleotids polymorphisms. Nature 409, 928-933 (2001). The work of several large collaborative groups, whose goal was to characterize the frequency and distribution characteristics of single nucleotide polymorphisms across the entire human genome.
    • (2001) Nature , vol.409 , pp. 928-933
    • Sachidanandam, R.1
  • 12
    • 0033865806 scopus 로고    scopus 로고
    • A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays
    • Pastinen, T. et al. A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays. Genome Res. 10, 1031-1042 (2000).
    • (2000) Genome Res. , vol.10 , pp. 1031-1042
    • Pastinen, T.1
  • 13
    • 17744380449 scopus 로고    scopus 로고
    • Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools
    • Hoogendoom, B. et al. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum. Genet. 107, 488-493 (2000).
    • (2000) Hum. Genet. , vol.107 , pp. 488-493
    • Hoogendoom, B.1
  • 14
    • 0035969948 scopus 로고    scopus 로고
    • Determination of SNP allele frequencies in pooled DNAs by primer extension genotyping and denaturing high-performance liquid chromatography
    • Giordano, M., Mellai, M., Hoogendoorn, B. & Momigliano-Richiardi. P. Determination of SNP allele frequencies in pooled DNAs by primer extension genotyping and denaturing high-performance liquid chromatography. J. Biochem. Biophys. Methods 47, 101-110 (2001).
    • (2001) J. Biochem. Biophys. Methods , vol.47 , pp. 101-110
    • Giordano, M.1    Mellai, M.2    Hoogendoorn, B.3    Momigliano-Richiardi, P.4
  • 15
    • 17344387757 scopus 로고    scopus 로고
    • Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation
    • Mein, C. A. et al. Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res. 10, 330-343 (2000).
    • (2000) Genome Res. , vol.10 , pp. 330-343
    • Mein, C.A.1
  • 16
    • 0033869814 scopus 로고    scopus 로고
    • Genotyping of factor V G1691A (Leiden) without the use of PCR by invasive cleavage of oligonucleotide probes
    • Hessner, M. J., Budish, M. A. & Friedman, K. D. Genotyping of factor V G1691A (Leiden) without the use of PCR by invasive cleavage of oligonucleotide probes. Clin. Chem. 46, 1051-1056 (2000).
    • (2000) Clin. Chem. , vol.46 , pp. 1051-1056
    • Hessner, M.J.1    Budish, M.A.2    Friedman, K.D.3
  • 17
    • 0034255677 scopus 로고    scopus 로고
    • A SNP shot: Pharmacogenetics and the future of drug therapy
    • Pfost, D. R., Boyce-Jacino, T. & Grant, D. M. A SNP shot: pharmacogenetics and the future of drug therapy. Trends Biotechnol. 18, 334-338 (2000).
    • (2000) Trends Biotechnol. , vol.18 , pp. 334-338
    • Pfost, D.R.1    Boyce-Jacino, T.2    Grant, D.M.3
  • 18
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Pui, C. H. & Evans, W. E. Acute lymphoblastic leukemia. N. Engl. J. Med. 339, 605-615 (1998).
    • (1998) N. Engl. J. Med. , vol.339 , pp. 605-615
    • Pui, C.H.1    Evans, W.E.2
  • 19
    • 0000389279 scopus 로고
    • The purine path to chemotherapy
    • Elion, G. B. The purine path to chemotherapy. Science 24, 4411-447 (1989).
    • (1989) Science , vol.24 , pp. 4411-4447
    • Elion, G.B.1
  • 20
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyl-transferase gene locus
    • Relling, M. V. et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyl-transferase gene locus. J. Natl Cancer Inst. 91, 2001-2008 (1999).
    • (1999) J. Natl Cancer Inst. , vol.91 , pp. 2001-2008
    • Relling, M.V.1
  • 21
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • Leonard, L, Lilleyman, J. S., Van Loon, J. & Weinshilboum, R. M. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 336, 225-229 (1990).
    • (1990) Lancet , vol.336 , pp. 225-229
    • Leonard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 22
    • 0027524983 scopus 로고
    • Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
    • Lennard, L, Gibson, B. E., Nicole, T. & Lilleyman, J. S. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch. Dis. Child 69, 577-579 (1993).
    • (1993) Arch. Dis. Child , vol.69 , pp. 577-579
    • Lennard, L.1    Gibson, B.E.2    Nicole, T.3    Lilleyman, J.S.4
  • 23
    • 0035423158 scopus 로고    scopus 로고
    • Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
    • Dervieux, T. et al. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer Res. 61, 5810-5816 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5810-5816
    • Dervieux, T.1
  • 24
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum, R. M. & Sladek, S. L. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am. J. Hum. Genet. 32, 651-662 (1980). This survey of 298 blood donors established a trimodal distribution for erythrocyte thiopurine methyltransferase activity, and classical family studies established that the three phenotypes were due to monogenic autosomal codominant inheritance. The authors suggested that the polymorphism could be used to predict response to thiopurine therapy, which was subsequently verified in many studies.
    • (1980) Am. J. Hum. Genet. , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.