메뉴 건너뛰기




Volumn 18, Issue 3 B, 1998, Pages 1989-1997

Apoptotic index correlates to bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers

Author keywords

Apoptosis; Apoptotic index; bc1 2; Breast cancer; p53; Prognostic factor

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

EID: 0031927561     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (91)

References (42)
  • 1
    • 0021346318 scopus 로고
    • Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
    • Wyllie AH, Morris RG, Smith AL, Dunlop D: Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142: 67-77, 1984.
    • (1984) J Pathol , vol.142 , pp. 67-77
    • Wyllie, A.H.1    Morris, R.G.2    Smith, A.L.3    Dunlop, D.4
  • 2
    • 0021902352 scopus 로고
    • The biology of cell death in tumours
    • Wyllie AH: The biology of cell death in tumours. Anticancer Res 5: 131-136, 1985.
    • (1985) Anticancer Res , vol.5 , pp. 131-136
    • Wyllie, A.H.1
  • 3
    • 0028559479 scopus 로고
    • Apoptosis in breast cancer as related to histopathological characteristics and prognosis
    • Lipponen P, Aaltomaa S, Kosma VM, Syrjanen K: Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Eur J Cancer 30A: 2068-2073, 1994.
    • (1994) Eur J Cancer , vol.30 A , pp. 2068-2073
    • Lipponen, P.1    Aaltomaa, S.2    Kosma, V.M.3    Syrjanen, K.4
  • 4
    • 0027956116 scopus 로고
    • Apoptosis in bladder cancer as related to standard prognostic factors and prognosis
    • Lipponen PK, Aaltomaa S: Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J Pathol 173: 333-339, 1994.
    • (1994) J Pathol , vol.173 , pp. 333-339
    • Lipponen, P.K.1    Aaltomaa, S.2
  • 5
    • 0028848548 scopus 로고
    • Association between the apoptotic index and established prognostic parameters in endometrial adenocarcinoma
    • Heatley MK: Association between the apoptotic index and established prognostic parameters in endometrial adenocarcinoma. Histopathology 27: 469-472, 1995.
    • (1995) Histopathology , vol.27 , pp. 469-472
    • Heatley, M.K.1
  • 6
    • 0030070626 scopus 로고    scopus 로고
    • Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling
    • Tatebe S, Ishida M, Kasagi N, Tsujitani S, Kaibara N, Ito H: Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling. Int J Cancer 65: 173-177, 1996.
    • (1996) Int J Cancer , vol.65 , pp. 173-177
    • Tatebe, S.1    Ishida, M.2    Kasagi, N.3    Tsujitani, S.4    Kaibara, N.5    Ito, H.6
  • 7
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6, 1994.
    • (1994) J Cell Biol , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 10
    • 0029049828 scopus 로고
    • Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
    • Moll UM, LaQuaglia M, Benard J, Riou G: Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 92: 4407-4411, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4407-4411
    • Moll, U.M.1    LaQuaglia, M.2    Benard, J.3    Riou, G.4
  • 11
    • 0028861937 scopus 로고
    • p53-independent death and p53- induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs
    • Malcomson RD, Oren M, Wyllie AH, Harrison DJ: p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs. Br J Cancer 72: 952-957, 1995.
    • (1995) Br J Cancer , vol.72 , pp. 952-957
    • Malcomson, R.D.1    Oren, M.2    Wyllie, A.H.3    Harrison, D.J.4
  • 12
    • 0028038019 scopus 로고
    • Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles
    • Runnebaum IB, Yee JK, Kieback DG, Sukumar S, Friedmann T: Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Res 14: 1137-1144, 1994.
    • (1994) Anticancer Res , vol.14 , pp. 1137-1144
    • Runnebaum, I.B.1    Yee, J.K.2    Kieback, D.G.3    Sukumar, S.4    Friedmann, T.5
  • 14
    • 0027143621 scopus 로고
    • Overexpression of p53 and prognosis in breast cancer
    • Friedrichs K, Gluba S, Eidtmann H, Jonat W: Overexpression of p53 and prognosis in breast cancer. Cancer 72: 3641-3647, 1993.
    • (1993) Cancer , vol.72 , pp. 3641-3647
    • Friedrichs, K.1    Gluba, S.2    Eidtmann, H.3    Jonat, W.4
  • 16
    • 0027944957 scopus 로고
    • Bcl-2 protein expression and long-term survival in breast cancer
    • Joensuu H, Pylkkanen L, Toikkanen S: Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 145: 1191-1198, 1994.
    • (1994) Am J Pathol , vol.145 , pp. 1191-1198
    • Joensuu, H.1    Pylkkanen, L.2    Toikkanen, S.3
  • 19
    • 0022783474 scopus 로고
    • What is apoptosis?
    • Wyllie AH: What is apoptosis? Histopathology 10: 995-998, 1986.
    • (1986) Histopathology , vol.10 , pp. 995-998
    • Wyllie, A.H.1
  • 20
    • 0025213177 scopus 로고
    • Correlation between histologic grade of malignancy and copy number of c-erbB-2 gene in breast carcinoma. A retrospective analysis of 176 cases
    • Tsuda H, Hirohashi S, Shimosato Y, Hirota T, Tsugane S, Watanabe S, Terada M, Yamamoto H: Correlation between histologic grade of malignancy and copy number of c-erbB-2 gene in breast carcinoma. A retrospective analysis of 176 cases. Cancer 65: 1794-1800, 1990.
    • (1990) Cancer , vol.65 , pp. 1794-1800
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3    Hirota, T.4    Tsugane, S.5    Watanabe, S.6    Terada, M.7    Yamamoto, H.8
  • 22
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 58: 457-481, 1958.
    • (1958) J Am Stat Assoc , vol.58 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 23
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox O: Regression models and life tables. J R Stat Soc Britain 32: 187-220, 1972.
    • (1972) J R Stat Soc Britain , vol.32 , pp. 187-220
    • Cox, O.1
  • 24
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
    • Bargou RC, Daniel PT, Mapara MY, Bommert K, Wagener C, Kallinich B, Royer HD, Dorken B: Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 60: 854-859, 1995.
    • (1995) Int J Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3    Bommert, K.4    Wagener, C.5    Kallinich, B.6    Royer, H.D.7    Dorken, B.8
  • 25
    • 0028115802 scopus 로고
    • bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer
    • Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL: bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 69: 135-139, 1994.
    • (1994) Br J Cancer , vol.69 , pp. 135-139
    • Leek, R.D.1    Kaklamanis, L.2    Pezzella, F.3    Gatter, K.C.4    Harris, A.L.5
  • 26
    • 0028247257 scopus 로고
    • Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype
    • For the International (Ludwig) Breast Cancer Study Group
    • Nathan B, Gusterson B, Jadayel D, O'Hare M, Anbazhagan R, Jayatilake H, Ebbs S, Micklem K, Price K, Gelber R, et al: Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype. For the International (Ludwig) Breast Cancer Study Group. Ann Oncol 5: 409-414, 1994.
    • (1994) Ann Oncol , vol.5 , pp. 409-414
    • Nathan, B.1    Gusterson, B.2    Jadayel, D.3    O'Hare, M.4    Anbazhagan, R.5    Jayatilake, H.6    Ebbs, S.7    Micklem, K.8    Price, K.9    Gelber, R.10
  • 27
    • 0030449990 scopus 로고    scopus 로고
    • Baxa perturbs T cell development and affects cell cycle entry of T cells
    • Brady HJM, Gil-Gomez G, Kirberg J, Berns AJM: Baxa perturbs T cell development and affects cell cycle entry of T cells. EMBO J 15: 6991-7001, 1996.
    • (1996) EMBO J , vol.15 , pp. 6991-7001
    • Hjm, B.1    Gil-Gomez, G.2    Kirberg, J.3    Berns, A.J.M.4
  • 28
    • 0030476922 scopus 로고    scopus 로고
    • The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
    • O'Reilly LA, Huang DC, Strasser A: The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J 15: 6979-6990, 1996.
    • (1996) EMBO J , vol.15 , pp. 6979-6990
    • O'Reilly, L.A.1    Huang, D.C.2    Strasser, A.3
  • 30
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 31
    • 0026659891 scopus 로고
    • Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients
    • Isola J, Visakorpi T, Holli K, Kallioniemi OP: Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients. J Natl Cancer Inst 84: 1109-1114, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1109-1114
    • Isola, J.1    Visakorpi, T.2    Holli, K.3    Kallioniemi, O.P.4
  • 33
    • 2642636608 scopus 로고    scopus 로고
    • Value of cancer-related oncoprotein expression as prognostic factors in breast-cancer with one to three axillary lymph nodes positive
    • Zhang G, Tsuda H, Adachi I, Fukutomi T, Yamamoto H, Hirohashi S: Value of cancer-related oncoprotein expression as prognostic factors in breast-cancer with one to three axillary lymph nodes positive. Gan To Kagaku Ryoho 23: 66-74, 1996.
    • (1996) Gan To Kagaku Ryoho , vol.23 , pp. 66-74
    • Zhang, G.1    Tsuda, H.2    Adachi, I.3    Fukutomi, T.4    Yamamoto, H.5    Hirohashi, S.6
  • 36
    • 0028609620 scopus 로고
    • Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells
    • Reynolds JE, Yang T, Qian L, Jenkinson JD, Zhou P, Eastman A, Craig RW: Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer Res 54: 6348-6352, 1994.
    • (1994) Cancer Res , vol.54 , pp. 6348-6352
    • Reynolds, J.E.1    Yang, T.2    Qian, L.3    Jenkinson, J.D.4    Zhou, P.5    Eastman, A.6    Craig, R.W.7
  • 38
    • 0029917541 scopus 로고    scopus 로고
    • Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
    • Zha H, Aime-Sempe C, Sato T, Reed JC: Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem 277: 7440-7444, 1996.
    • (1996) J Biol Chem , vol.277 , pp. 7440-7444
    • Zha, H.1    Aime-Sempe, C.2    Sato, T.3    Reed, J.C.4
  • 39
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-291, 1995.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 41
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski S, Blomqvist C, Franssila K, Krajewska M, Wasenius VM, Niskanen E, Nordling S, Reed JC: Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55: 4471-4478, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3    Krajewska, M.4    Wasenius, V.M.5    Niskanen, E.6    Nordling, S.7    Reed, J.C.8
  • 42
    • 0029945789 scopus 로고    scopus 로고
    • Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas
    • Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 56: 2422-2427, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2422-2427
    • Krajewska, M.1    Moss, S.F.2    Krajewski, S.3    Song, K.4    Holt, P.R.5    Reed, J.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.