The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients

Clinical Cancer Research

Volumn 2, Issue 7, 1996, Pages 1199-1206

  Oesterreich, Steffi ^a   Hilsenbeck, Susan G ^a   Ciocca, Daniel R ^b   Allred, D Craig ^a   Clark, Gary M ^a   Chamness, Gary C ^a   Osborne, C Kent ^a   Fuqua, Suzanne A W ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Laboratorio de Reproduccion y Lactancia Mendoza   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; HEAT SHOCK PROTEIN;

ACTIN POLYMERIZATION; ANEUPLOIDY; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CELL CYCLE S PHASE; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FAMILY; TREATMENT OUTCOME;

ADULT; AGED; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; PROGNOSIS; RECEPTORS, ESTROGEN;

EID: 0029951848     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Ciocca, D. R., Osterreich, S., Chamness G. C., McGuire, W. L., and Fuqua, S. A. W. Biological and clinical implications of heat shock protein 27,000 (hsp27): a review. J. Natl. Cancer Inst., 85: 1558-1570, 1993.
2. r 27,000 heat shock protein. Cancer Res., 51. 245-252, 1991.
3. Osterreich, S., Weng, C-N., Qiu, M., Hilsenbeck, S., Osborne, C. K., and Fuqua, S. A. W. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res., 55: 4443-4448, 1993.
4. Miron, T., Wilchek, M., and Geiger, B. Characterization of an inhibitor of actin polymerization in vinculin-rich fraction of turkey gizzard smooth muscle. Eur. J. Biochem., 178: 543-553, 1988.
5. Miron, T., Vancompernolle, K., and Vandekerckhove, J. A 25 kDa inhibitor of actin polymerization is a low molecular mass heat shock protein. J. Cell. Biol., 114: 255-261, 1991.
6. Horwitz, J. Alpha-crystallin can function as a molecular chaperone. Proc. Nat. Acad. Sci. USA, 89: 10449-10453, 1992.
7. Jakob, U., Gaestel, M., Engel, K., and Buchner, J. Small heat shock proteins are molecular chaperones. J. Biol. Chem., 268: 1517-1520, 1993.
8. Moretti-Rojas, I., Fuqua, S. A. W, Montgomery, R. A. I., and McGuire, W. L. A cDNA for the estradiol-regulated 24K protein: control of mRNA levels in MCF-7 cells. Breast Cancer Res. Treat., 11: 155-163, 1988.
9. Fuqua, S. A. W., Blum-Salingaros, M., and McGuire, W. L. Induction of the estrogen regulated "24K" protein by heat shock. Cancer Res., 49: 4126-4129, 1989.
10. Ciocca, D. R., Adams, D. P., Edwards, R. J., Bjercke, R. J., and McGuire, W. L. Distribution of an estrogen-regulated protein with a molecular weight of 24,000 in normal and malignant human tissues and cells. Cancer Res , 43: 1204-1210, 1988.
11. r 24,000 protein in human breast tumors: correlations with estrogen and progesterone receptors. Cancer Res., 45: 2445-2449, 1985.
12. Storm, F. K., Mahvi, D. M., and Gilchrist, K. Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers. Urology, 42: 379-382, 1993.
13. Tetu, B., Lacasse, B., Bouchard, H-L , Lagace, R , Huot, J., and Landry, J. Prognostic influence of hsp-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study. Cancer Res., 52: 2325-2328, 1992.
14. Ungar, D. R., Hailat, N., Strahler, J. R. Kuick, R. D., Brodeur, G. M., Seeger, R. C., Reynolds, C. P , and Hanash, S. M. Hsp27 expression in neuroblastoma: correlation with disease stage. J. Natl. Cancer Inst., 86: 780-784, 1994.
15. Tandon, A. K., Clark, G. M., Chamness, G. C., Fuqua, S. A. W., Welch, W. J., Riehl, R. M., and McGuire, W. L. Heat shock stress response proteins: biological and clinical significance in breast cancer. Proc. Am. Soc. Clin. Oncol., 9: 84, 1990.
16. Thor, A., Benz, C., Moore, D. I., Goldman, E., Edgerton, S., Landry, J., Schwartz, L., Mayall, B., Hickey, E., and Weber, L. A. Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J. Natl. Cancer Inst., 83: 170-178, 1991.
17. Love, S , and King, R. J. B A 27 kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer. Br. J. Cancer, 69: 743-748, 1994.
18. r 52,000 and DF3 breast cancer associated antigen: clinical value in advanced breast cancer and correlation with estrogen receptor. Ann. Oncol., 3. 71-77, 1992.
19. Tetu, B., Brisson, J., Landry, J., and Huot, J. Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: an immunhistochemical study. Breast Cancer Res. Treat., 36. 93-97, 1995.
20. Hurlimann, J., Gebhard S., and Gomez, F. Oestrogen receptor, progesterone receptor, pS2, ERD5. HSP27 and cathepsin D in invasive ductal breast cancer. Histopathology, 23: 239-248, 1993.
21. Seymour, L., Bezwoda, W. R., and Meyer, K. Tumor factors predicting for prognosis in metastatic breast cancer: the presence of p24 predicts for response to treatment and duration of survival. Cancer (Phila.), 66: 2390-2394, 1990.
22. Dressier, L. G., Seamer, L. C., Owens, M. A, Clark, G. M., and McGuire, W. L. DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens. Cancer (Phila.), 61: 420-427, 1988.
23. Wenger, C. R., Beardslee, S., Owens, M. A., Pounds, G., Oldaker, T., Vendelay, P., Pandian, M. R., Harrington, D., Clark, G. M., and McGuire, W. L. DNA ploidy, S-phase and steroid receptors in more than 127,000 breast cancer patients. Breast Cancer Res. Treat., 28: 9-20, 1993.
24. Clark, G. M., Dressier, L. G., Owens, M. A., Pounds, G., Oldaker, T., and McGuire, W. L. Prediction of relapse or survival in patients with node-negative breast cancer by DNA flow cytometry. N. Engl. J. Med., 320: 627-633, 1989.
25. Tandon, A. K., Clark, G. M., Chamness, G. C., Ullrich, A., and McGuire, W L. Her-2/neu oncogene protein and prognosis in breast cancer J. Clin. Oncol., 7: 1120-1128, 1989.
26. Tandon, A. K., Clark, G. M., Chamness, G. C., and McGuire, W. L. Cathepsin D and prognosis in breast cancer. N. Engl. J. Med., 322: 297-302, 1990.
27. r 24,000 estrogen-regulated protein in human breast cancer by monoclonal antibodies. Cancer Res., 43: 4297-4301, 1983.
28. Allred, D. C., Tandon, A. K., Clark, G. M., Brown, R. W., Abbondanzo, S. L., and McGuire, W. L. Comprehensive evaluation of prognostic factors by immunocytochemistry on extremely small samples (50 mg) of "pulverized" breast carcinomas. Breast Cancer Res. Treat., 16: 182, 1990.
29. Ciocca, D. R., and Bjercke, R. J. Immunocytochemical techniques using monoclonal antibodies. Methods Enzymol., 121: 562-579, 1986.
30. Molina, R., Ciocca, D. R., Tandon, A. K., Allred, D. C., Clark, G. M., Chamness, G. C., Gullick, W. J., and McGuire, W. L. Expression of Her-2/neu oncoprotein in human breast cancer: a comparison of immunohistochemical and Western blot techniques. Anticancer Res., 12: 1965-1972, 1992.
31. Elledge, R. M., Ciocca, D. R., Langone, G., and McGuire, W. L. Estrogen receptor, progesterone receptor, and Her-2/neu protein in breast cancers from pregnant patients. Cancer (Phila.), 71: 2499-2506, 1993.
32. Cox, D. R., and Oakes, D. Analysis of survival data. New York: Chapman and Hall, 1984.
33. Hilsenbeck, S. G., and Clark, G. M. A practical method P-value adjustment. Stat. Med., 15: 102-112, 1996.
34. Hilsenbeck, S. G., Clark, G. M., and McGuire, W. L. Why do so many prognostic factors fail to pan out? Breast Cancer Res. Treat., 22: 197-206, 1992.
35. Bielka, H., Hoinkis, G., Oesterreich, S., Stahl, H-J., and Benndorf, R. Induction of the small stress protein, hsp25, in Ehrlich ascites carcinoma cells by anticancer drugs. FEBS Letts., 343. 165-167, 1994.
36. Dunn, D. K., Whelan, R. D., Hill, B., and King, R. J. Relationship of hsp27 and oestrogen receptor in hormone sensitive and insensitive cell lines. J. Steroid Biochem. Mol. Biol., 46: 469-479, 1993.
37. Mairesse, N., Horman, S., Mosselmans, R., and Galand, P. Antisense inhibition of hsp27 production affects growth rate and cytoskeleton organization in MCF-7 cells. J. Cell. Biochem., 19B: 100, 1995.
38. Condeelis, J Life at the leading edge: the formations of cell protrusions. Ann. Rev. Cell Biol., 9: 411-444, 1993.
39. Stossel, T. P. On the crawling of animal cells. Science (Washington DC), 260: 1086-1094, 1993.