Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion

British Journal of Cancer

Volumn 81, Issue 4, 1999, Pages 592-599

  Vakkala, M ^a   Paakko P ^a   Soini, Y ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Apoptosis; Breast; Carcinoma; Caspase

Indexed keywords

ANTIBODY; CASPASE; CASPASE 3; CASPASE 6; CASPASE 8; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; BREAST DISEASE; BREAST DUCT; BREAST EPITHELIUM; BREAST HYPERPLASIA; BREAST LESION; CANCER GRADING; CANCER SURVIVAL; CARCINOMA IN SITU; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BREAST; BREAST NEOPLASMS; CARCINOMA IN SITU; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE 9; CASPASES; FEMALE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; PRECANCEROUS CONDITIONS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0032881750     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690735     Document Type: Article

References (51)

1. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J (1996) Human JCE/CED-3 protease nomenclature. Cell 87: 171
2. Barge RMY, Willemze R, Vandenabecle P, Fiers W and Beyaert R (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 409: 207-210
3. Barnes R and Masood S (1990) Potential value of hormone receptor assay in carcinoma in-situ of breast. Am J Clin Pathol 94: 533-537
4. Brancolini C, Lazarevic D, Rodriguez J and Schneider C (1997) Dismantling cell cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of β-catenin. J Cell Biol 139: 759-771
5. Bur ME, Zimarowski MJ, Schnitt SJ, Baker S and Lew R (1992) Estrogen receptor activity in carcinoma in-situ of the breast. Cancer 69: 1174-1181
6. Caulin C, Salvesen GS and Oshima RG (1997) Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 138: 1379-1394
7. Chen L, Marechal V, Moreau J, Levine AJ and Chen J (1997) Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J Biol Chem 272: 22966-22973
8. Chhanabhai M, Krajewski S, Krajewska M, Wang HG, Reed JC and Gascoyne RD (1997) Immunohistochemical analysis of interleukin-1 beta-converting enzyme/Ced-3 family protease. CCP32/Yama/Caspase-3 in Hodgkin's disease. Blood 90: 2451-2455
9. Clem RJ, Cheng EH, Karp CL, Kirch DG, Ueno K, Takahashi A, Kastan MB, Griffin DF, Earnshaw WC, Veliuona MA and Hardwick JM (1998) Modulation of cell death by Bcl-xL through caspase interaction. Proc Natl Acad Sci USA 95: 554-559
10. Droin N, Dubrez L, Eymin B, Renvoize C, Breard J, Dimanche-Boitrel MT and Solary E (1998) Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Oncogene 16: 2885-2894
11. Elston CW and Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long term follow-up. Histopathology 19: 403-410
12. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A and Nagata S (1998) A caspase-activated DNAase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-40
13. Faleiro L, Kobayashi R, Fearnhead H and Lazebnik Y (1997) Multiple species of CCP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J 16: 2271-2281
14. Fraser A and Evan G (1996) A license to kill. Cell 85: 781-784
15. Fujita N and Tsuruo T (1998) Involvement of bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis. Biochem Biophys Res Commun 246: 484-488
16. Harvey NL, Bull AJ and Kumar S (1997) Functional activation of Ncdd2/ICH-I (Caspase-2) is an early process in apoptosis. J Biol Chem 272: 13134-13139
17. Helin HJ, Helle MJ, Kallioniemi O P and Isola J (1989) Immunohistochemical determination of estrogen and progesterone receptors in human breast carcinoma. Cancer 63: 1761-1767
18. Holland R, Hendricks JHCL, Verbeck ALM, Mravanac M and Schuurmans-Stekhoven JH (1990) Extent, distribution and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet 335: 519-522
19. Janicke RU, Sprengart ML, Wati MR and Porter AG (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-9360
20. Kerr JFR, Winterford CM and Harmon BV (1994) Apoptosis. Its significance in cancer and cancer therapy. Cancer 73: 2013-2026
21. Kluck RM, Bossy-Wetzel E, Green DR and Nwemeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science 275: 1132-1136
22. Krajewska M, Wang H-G, Krajewski S, Zapata JM, Shabaik A, Gascoyne R and Reed JC (1997) Immunohistochemical analysis of in vivo pattern or expression of CCP32 (caspase-3), a cell death protease. Cancer Res 57: 1605-1613
23. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG and Reed JC (1994) Immunohistochemical determination of in vivo distribution of bax, a dominant inhibitor of bcl-2. Am J Pathol 145: 1323-133
24. Krajewski S, Gascoyne RD, Zapata JM, Krajewska M, Kitada S, Chhanabhai M, Horsman D, Berean K, Piro LD, Fugier Vivier I, Liu YJ, Wang HG and Reed JC (1997) Immunolocalization of the ICE/Ced-3-family protease, CPP32 (caspase-3) in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes. Blood 89: 3817-3825
25. Kröemer G (1997) The proto-oncogene bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620
26. Lipponen P, Aaltomaa S, Kosma V-M and Syrjänen K (1994) Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Eur J Cancer 30A: 2068-2073
27. Liu X, Naekyung C, Yang J, Jemmerson R and Wang J (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157
28. Mack L, Kerkvliet N, Doig G and O'Malley FP (1997) Relationship of a new histological categorization of ductal carcinoma in situ of the breast with size and the immunohistochemical expression of p53, c-erbB2, bcl-2 and Ki-67. Hum Pathol 28: 974-979
29. Manon S, Chaudhuri B and Guerin M (1997) Release of cytochrome c and decrease of cytochrome c oxidase in bax expressing yeast cells, and prevention of these effects by coexpression of bel xL. FEBS Lett 415: 29-32
30. Martins LM, Kottke T, Mesner PW, Basi GS, Sinha S, Frigon N, Tatar E, Tung JS, Bryant K, Takahashi A, Svingen PA, Madden BJ, McGormick DJ, Dernshaw WC and Kaufmann SH (1997) Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272: 7421-7430
31. Minn AJ, Velez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M and Thompson CB (1997) Bel-xL forms an ion channel in synthetic lipid membranes. Nature 385: 353-357
32. Mustonen M, Raunio H, Pääkkö P and Soini Y (1997) The extent of apoptosis is inversely associated with bcl-2 expression in premalignant and malignant breast lesions. Histopathology 31: 347-354
33. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevehenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Munn M, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED3-like protease is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827
34. Nagata S (1997) Apoptosis by death factor. Cell 88: 355-365
35. Nijhawan LP, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489
36. O'Malley FP, Vnencak Jones CL, Dupont WD, Parl F, Manning S and Page DL (1994) p53 mutations are confined to the comedo type ductal carcinoma in situ of the breast. Immunohistochemical and sequencing data. Lab Invest 71: 67-72
37. Patel T, Gores GJ and Kaufmann SH (1996) The role of proteases during apoptosis. FASEB J 10: 587-597
38. Rao L, Perez D and White E (1996) Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 135: 1441-1455
39. Rosen PP and Oberman HA (1992) Tumors of the Mammary Gland. Atlas of Tumor Pathology, Third Series, Fascicle 7. Armed Forces Institute of Pathology: Washington, DC
40. Soini Y, Virkajävi N, Lehto V-P and Pääkkö P (1996) Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br J Cancer 73: 1025-1030
41. Soini Y, Pääkkö P Lehto V-P (1998) Histopathological evaluation of apoptosis in cancer. Am J Pathol 153: 1041-1053
42. Tan X, Martin SJ, Green DR and Wang JYJ (1997) Degradation of retinoblastoma protein in tumor necrosis factor- and CD95 induced cell death. J Biol Chem 272: 9613-9616
43. Tavassoli FA (1992) Pathology of the Breast. Appleton & Lange, Norwalk, Connecticut, USA. pp. 155-191
44. Thomberry NA and Lazebnik Y (1998) Caspases: enemies within. Science 281: 1312-1316
45. Thomberry NA, Peterson EP, Zhao JJ, Howard AD, Griffin PR and Chapman KT (1994) Inactivation of interleukin-1β converting enzyme by peptide (acyloxy)methyl ketones. Biochemistry 33: 3934-3940
46. Törmänen U, Ecrola A-K, Rainio P, Vähäkangas K, Soini Y, Sormunen R, Bloigu R, Lehto V-P, Pääkkö P (1995) Enhanced apoptosis predicts shortened survival in non-smalll cell lung carcinoma. Cancer Res 55: 5595-5602
47. van de Vijver MJ, Peterse JL, Mooi WJ, Wisman P, Lomans J, Dalesion O and Nusse R (1988) Neu-protein overexpression in breast cancer. Association with comedo type ductal carcinomas in situ and limited prognostic value in stage II breast cancer. New Engl J Med 319: 1230-1245
48. Virkajärvi N, Pääkkö P and Soini Y (1998) Apoptotic index and apoptosis influencing proteins bcl-2, mcl-1, bax and caspases 3, 6 and 8 in pancreatic carcinoma. Histopathology 33: 432-439
49. Wang TTY and Phang JM (1995) Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res 35: 2487-2489
50. Yang E and Korsmeyer SK (1996) Molecular thanatopsis; a discourse on the bcl-2 family and cell death. Blood 88: 386-401
51. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X (1997) Prevention of apoptosis by bcl-2; release of cytochrome c from mitochondria blocked. Science 275: 1129-1132