Exploring the potential of xenobiotic-metabolising enzymes as biocatalysts: Evolving designer catalysts from polyfunctional cytochrome P450 enzymes

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 3, 2005, Pages 147-152

  Gillam, Elizabeth M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Biocatalysis; CYP2C9; CYP3A4; Cytochrome P450; Directed evolution; DNA shuffling; Drug metabolism; Xenobiotic metabolism

Indexed keywords

BACTERIAL ENZYME; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; ENZYME;

BIOCATALYST; BIOREMEDIATION; CATALYSIS; CHEMICAL REACTION; DIRECTED MOLECULAR EVOLUTION; DNA SHUFFLING; DRUG INDUSTRY; DRUG METABOLISM; ENZYME ENGINEERING; ENZYME SPECIFICITY; NONHUMAN; SHORT SURVEY; STEREOSPECIFICITY; SYNTHESIS; XENOBIOTIC METABOLISM;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DNA SHUFFLING; DRUG DESIGN; HUMANS; MUTATION; PHARMACEUTICAL PREPARATIONS; PROTEIN ENGINEERING; STEREOISOMERISM; XENOBIOTICS;

EID: 15244353524     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04165.x     Document Type: Short Survey

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