Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37519-37526

  Chen, Xuehui ^a   Christopher, Alexandra ^a   Jones, Jonathan P ^a   Bell, Stephen G ^a   Guo, Qing ^a   Xu, Feng ^a   Rao, Zihe ^a,b   Wong, Luet Lok ^a  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBONS; BIOREMEDIATION; CATALYSIS; CHEMICAL BONDS; CHLORINE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; MICROORGANISMS; OXIDATION;

MUTANTS;

PROTEINS;

1,3,5 TRICHLOROBENZENE; BENZENE DERIVATIVE; CAMPHOR 5 MONOOXYGENASE; CARBON; CHLORINE; CYTOCHROME P450; CYTOCHROME P450 101; HEME; HEXACHLOROBENZENE; HYDROGEN; IRON; MUTANT PROTEIN; PENTACHLOROBENZENE; PORPHYRIN; UNCLASSIFIED DRUG;

ARTICLE; BIOREMEDIATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR INTERACTION; MUTATION; OXIDATION; PRIORITY JOURNAL; PROTEIN ENGINEERING;

AMINO ACID SUBSTITUTION; BINDING SITES; BIODEGRADATION, ENVIRONMENTAL; CAMPHOR 5-MONOOXYGENASE; CATALYSIS; CHLOROBENZENES; CRYSTALLOGRAPHY, X-RAY; HEXACHLOROBENZENE; KINETICS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PSEUDOMONAS PUTIDA; RECOMBINANT PROTEINS;

DRYOBALANOPS; JONES; LEPUS; PSEUDOMONAS; PSEUDOMONAS PUTIDA;

EID: 0037020229     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203762200     Document Type: Article

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