Much anticipated - The bioactive conformation of epothilone and its binding to tubulin

Angewandte Chemie - International Edition

Volumn 44, Issue 9, 2005, Pages 1298-1301

  Heinz, Dirk W ^a   Schubert, Wolf Dieter ^a   Höfle, Gerhard ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Conformation analysis; Electron crystallography; Macrocycles; Molecular modeling; Natural products

Indexed keywords

BINDING ENERGY; CELLS; CONFORMATIONS; CRYSTALLOGRAPHY; POLYMERIZATION;

BIOACTIVE CONFORMATION; ELECTRON CRYSTALLOGRAPHY; EPOTHILONES; TUBULIN BINDING CAVITY;

PROTEINS;

DOCETAXEL; EPOTHILONE A; EPOTHILONE B; PACLITAXEL; TUBULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BINDING AFFINITY; BINDING SITE; CRYSTALLIZATION; CYTOTOXICITY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; EUKARYOTIC CELL; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; PROTEIN POLYMERIZATION; REVIEW; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY; CYTOCHROME P-450 ENZYME SYSTEM; EPOTHILONES; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUTATION; OXIDOREDUCTASES; PACLITAXEL; PROTEIN BINDING; TUBULIN;

EID: 14844338576     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200462241     Document Type: Review

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