Conformation-activity relationships in polyketide natural products: A new perspective on the rational design of epothilone analogues

Journal of the American Chemical Society

Volumn 125, Issue 1, 2003, Pages 26-27

  Taylor, Richard E ^a   Chen, Yue ^a   Beatty, Alicia ^a   Myles, David C ^b   Zhou, Yiqing ^b  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b KOSAN BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE B; EPOTHILONE DERIVATIVE; EPOXIDE; ETHER DERIVATIVE; HYDROXYL GROUP; NATURAL PRODUCT; POLYKETIDE; TERT BUTOXYDIPHENYLSILYL ETHER; UNCLASSIFIED DRUG;

ARTICLE; CANCER; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EPOXIDATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; STEREOCHEMISTRY; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; EPOTHILONES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037425543     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja028196l     Document Type: Article

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