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Volumn 38, Issue 26, 1997, Pages 4529-4532

Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPOTHILONE A; EPOTHILONE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG;

EID: 0030950914     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00931-3     Document Type: Article
Times cited : (44)

References (21)
  • 15
    • 0342395842 scopus 로고    scopus 로고
    • note
    • 3 epimers.
  • 17
    • 0343265501 scopus 로고    scopus 로고
    • note
    • 8 methyl on the stereoselectivity of epoxidation by dimethydioxirane and the dramatic reduction of biological activity are related. Molecular modeling studies designed to explore this theme are under way.
  • 18
    • 0342395843 scopus 로고    scopus 로고
    • note
    • 15 Drugs were tested at a concentration of 10 μM, in the absence of GTP. Microtubule formation was verified by electron microscopy. To determine the stability of microtubules assembled in the presence of GTP or drug, turbidity was followed for 40 min after the reaction temperature was shifted to 4°C.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.