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0342395842
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3 epimers.
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17
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0343265501
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note
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8 methyl on the stereoselectivity of epoxidation by dimethydioxirane and the dramatic reduction of biological activity are related. Molecular modeling studies designed to explore this theme are under way.
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18
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0342395843
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note
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15 Drugs were tested at a concentration of 10 μM, in the absence of GTP. Microtubule formation was verified by electron microscopy. To determine the stability of microtubules assembled in the presence of GTP or drug, turbidity was followed for 40 min after the reaction temperature was shifted to 4°C.
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