Crystal Structures of Epothilone D-bound, Epothilone B-bound, and Substrate-free Forms of Cytochrome P450epoK

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44886-44893

  Nagano, Shingo ^a   Li, Huiying ^a   Shimizu, Hideaki ^a,d   Nishida, Clinton ^c   Ogura, Hiroshi ^c   Ortiz de Montellano, Paul R ^c   Poulos, Thomas L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; CYTOLOGY; DRUG THERAPY;

ANTICANCER DRUGS;

BIOCHEMISTRY;

BINDING PROTEIN; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450EPOK; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE D; EPOTHILONE DERIVATIVE; HEME; MACROLIDE; PACLITAXEL; THIAZOLE; TUBULIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; MICROTUBULE; MYXOCOCCALES; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; SORANGIUM CELLULOSUM; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; EPOTHILONES; ESCHERICHIA COLI; HEME; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYXOCOCCALES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TUBULIN;

MYXOCOCCALES; POLYANGIUM CELLULOSUM;

EID: 0242582120     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308115200     Document Type: Article

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