Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies

Current Medicinal Chemistry

Volumn 12, Issue 3, 2005, Pages 267-275

  Pacher, Pál ^a   Obrosova, Irina G ^b   Mabley, Jon G ^c   Szabó, Csaba ^d,e,f  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF BRIGHTON   (United Kingdom)

^d INOTEK CORPORATION   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^f SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Cardiomyopathy; Diabetes; Nephropathy; Neuropathy; Nitric oxide; Nitrotyrosine; Peroxynitrite; Retinopathy; Superoxide; Vascular

Indexed keywords

3 NITROTYROSINE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; CYTOTOXIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DNA; FIDARESTAT; GLUCOSE; HEMOGLOBIN A1C; INTERCELLULAR ADHESION MOLECULE 1; METALLOPORPHYRIN; N(G) NITROARGININE METHYL ESTER; NEUROHORMONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; PEROXYNITRITE; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SORBINIL; SUPEROXIDE; UROKINASE RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1;

AMINO ACID BLOOD LEVEL; APOPTOSIS; BLOOD GLUCOSE MONITORING; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; CELL DEATH; CEREBROVASCULAR ACCIDENT; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE COURSE; DNA REPAIR; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; ENDOTHELIUM INJURY; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HEART MUSCLE; HISTOPATHOLOGY; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOTHESIS; MORBIDITY; MORTALITY; NITRATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; POLYMERIZATION; PREDICTION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RECEPTOR UPREGULATION; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 14544297961     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867053363207     Document Type: Review

References (106)

1. Brownlee, M. Nature, 2001, 14, 813-820.
2. Ceriello, A. Diabetes Care, 2003, 26, 1589-1596.
3. Ruderman, N.B.; Williamson, J.R.; Brownlee, M. FASEB. J. 1992, 6, 2905-2914.
4. Hoeldtke, R.D. Clin. Auton. Res., 2003, 13 6), 406-421.
5. Nagai, R.; Unno, Y.; Hayashi, M.C.; Masuda, S.; Hayase, F.; Kinae, N.; Horiuchi, S. Diabetes, 2002, 51(9), 2833-2839.
6. Virag, L.; Szabo, E.; Gergely, P.; Szabo, C. Toxicol. Lett., 2003, 140-141, 113-124.
7. Matata, B.M.; Galinanes, M. J. Thorac. Cardiovasc. Surg. 2000, 120(1), 1-11.
8. Ceriello, A.; Mercuri, F.; Quagliaro, L.; Assaloni, R.; Motz, E.; Tonutti, L.; Taboga, C. Diabetologia, 2001, 44, 834-838.
9. Aydin, A.; Orhan, H.; Sayal, A.; Ozata, M.; Sahin, G.; Isimer, A. Clin. Biochem., 2001, 34, 65-70.
10. Ceriello, A.; Taboga, C.; Tonutti, L.; Quagliaro, L.; Piconi, L.; Bais, B.; Da Ros, R.; Motz, E. Circulation, 2002, 106 10), 1211-1218.
11. Ceriello, A.; Quagliaro, L.; Catone, B.; Pascon, R.; Piazzola, M.; Bais, B.; Marra, G.; Tonutti, L.; Taboga, C.; Motz, E. Diabetes Care, 2002, 25, 1439-1443.
12. Hoeldtke, R.D.; Bryner, K.D.; McNeill, D.R.; Warehime, S.S.; Van Dyke, K.; Hobbs, G. J. Clin. Endocrinol. Metab., 2003, 88(4), 1624-1628.
13. Hoeldtke, R.D.; Bryner, K.D.; McNeill, D.R.; Hobbs, G.R.; Baylis, C. Am. J Hypertens., 2003, 16(9 Pt. 1), 761-766.
14. Rabini, R.A.; Vignini, A.; Salvolini, E.; Staffolani, R.; Martarelli, D.; Moretti, N.; Mazzanti, L. Atherosclerosis, 2002 165(1), 69-77.
15. Tannous, M.; Rabini, R.A.; Vignini, A.; Moretti, N.; Fumelli, P.; Zielinski, B.; Mazzanti, L.; Mutus B. Diabetologia, 1999, 42(5), 539-544.
16. Garcia, Soriano F.; Virág, L.; Jagtap, P.; Szabó, É.; Mabley, J.G.; Liaudet, L.; Marton, A.; Hoyt, D.G.; Murthy, K.G.; Salzman, A.L.; Southan, G.J.; Szabo, C. Nature Medicine, 2001 7, 108-113.
17. Szabo, C.; Zanchi, A.; Komjati, K.; Pacher, P.; Krolewski, A.S.; Quist, W.C.; LoGerfo, F.W.; Horton, E.S.; Veves, A. Circulation 2002, 106, 2680-2686.
18. Szabo, C.; Mabley, J.G.; Moeller, S.M.; Shimanovich, R.; Pacher, P.; Virag, L.; Soriano, F.G.; Van Duzer, J.H.; Williams, W.; Salzman, A.L.; Groves, J.T. Mol. Med., 2002, 8, 571-580.
19. Zou, M.H.; Shi, C.; Cohen, R.A. Diabetes, 2002, 51, 198-203.
20. Quagliaro, L.; Piconi, L.; Assaloni, R.; Martinelli, L.; Motz, E.; Ceriello, A. Diabetes, 2003, 52(11), 2795-2804.
21. Cosentino, F.; Eto, M.; De Paolis, P.; van der Loo, B.; Bachschmid, M.; Ullrich, V.; Kouroedov, A.; Delli, Gatti C.; Joch, H.; Volpe, M.; Luscher, T.F. Circulation, 2003, 107, 1017-1023.
22. Pricci, F.; Leto, G.; Amadio, L.; Iacobini, C.; Cordone, S.; Catalano, S.; Zicari, A.; Sorcini, M.; Di Mario, U.; Pugliese, G. Free Radic. Biol. Med., 2003, 35(6), 683-694.
23. Stadler, K.; Jenei, V.; von Bolcshazy, G.; Somogyi, A.; Jakus, J. Free Radic. Biol. Med., 2003, 35(10), 1240-1251.
24. Brodsky, S.V.; Gealekman, O.; Chen, J.; Zhang, F.; Togashi, N.; Crabtree, M.; Gross, S.S.; Nasjletti, A.; Goligorsky, M.S. Circ. Res., 2004, 94(3), 377-384.
25. Frustaci, A.; Kajstura, J.; Chimenti, C.; Jakoniuk, I.; Leri, A.; Maseri, A.; Nadal-Ginard, B.; Anversa, P. Circ. Res., 2000 87, 1123-1132.
26. Kajstura, J.; Fiordaliso, F.; Andreoli, A.M.; Li, B.; Chimenti, S.; Medow, M.S.; Limana, F.; Nadal-Ginard, B.; Leri, A.; Anversa, P. Diabetes, 2001, 50(6), 1414-1424.
27. Turko, I.V.; Marcondes, S.; Murad, F. Am. J. Physiol., 2001, 281, 2289-2294.
28. Ceriello, A.; Quagliaro, L.; D'Amico, M.; Di Filippo, C.; Marfella, R.; Nappo, F.; Berrino, L.; Rossi, F.; Giugliano, D. Diabetes, 2002, 51, 1076-1082.
29. Turko, I.V.; Li, L.; Aulak, K.S.; Stuehr, D.J.; Chang, J.Y.; Murad, F. J. Biol. Chem., 2003, 278(36), 33972-33977.
30. Suarez-Pinzon, W.L.; Szabo, C.; Rabinovitch, A. Diabetes 1997, 46(5), 907-911.
31. Lyall, F.; Gibson, J.L.; Greer, I.A.; Brockman, D.E.; Eis, A.L.; Myatt L. Diabetes Care, 1998, 21(10), 1753-1758.
32. Kossenjans, W.; Eis, A.; Sahay, R.; Brockman, D.; Myatt, L. Am. J. Physiol. Heart. Circ. Physiol., 2000, 278(4), H1311-1319.
33. Thuraisingham, R.C.; Nott, C.A.; Dodd, S.M.; Yaqoob, M.M. Kidney Int., 2000, 57(5), 1968-1972.
34. Ishii, N.; Patel, K.P.; Lane, P.H.; Taylor, T.; Bian, K.; Murad, F.; Pollock, J.S.; Carmines, P.K. J. Am. Soc. Nephrol., 2001, 12(8), 1630-1639.
35. Forbes, J.M.; Cooper, M.E.; Thallas, V.; Burns, W.C.; Thomas, M.C.; Brammar, G.C.; Lee, F.; Grant, S.L.; Burrell, L.A.; Jerums, G.; Osicka, T.M. Diabetes, 2002, 51(11), 3274-3282.
36. Onozato, M.L.; Tojo, A.; Goto, A.; Fujita, T.; Wilcox, C.S. Kidney Int., 2002, 61, 186-194, 2002.
37. Du, X.; Matsumura, T.; Edelstein, D.; Rossetti, L.; Zsengeller, Z.; Szabo, C.; Brownlee, M. J. Clin. Invest., 2003 112, 1049-1057.
38. Ellis, E.A.; Guberski, D.L.; Hutson, B.; Grant, M.B. Nitric Oxide, 2002, 6, 295-304.
39. Kowluru, R.A. Diabetes, 2003, 52(3), 818-823.
40. El-Remessy, A.B.; Behzadian, M.A.; Abou-Mohamed, G.; Franklin, T.; Caldwell, R.W.; Caldwell, R.B. Am. J. Pathol., 2003, 162, 1995-2004.
41. El-Remessy, A.B.; Abou-Mohamed, G.; Caldwell, R.W.; Caldwell, R.B. Invest. Ophthalmol. Vis. Sci., 2003, 44(7), 3135-3143.
42. Coppey, L.J.; Gellett, J.S.; Davidson, E.P.; Dunlap, J.A.; Lund, D.D.; Yorek, M.A. Diabetes, 2001, 50, 1927-1937.
43. Coppey, L.J.; Gellett, J.S.; Davidson, E.P.; Dunlap, J.A.; Lund, D.D.; Salvemini, D.; Yorek M.A. Br. J. Pharmacol., 2001 134(1), 21-29.
44. Hoeldtke, R.D.; Bryner, K.D.; McNeill, D.R.; Hobbs, G.R.; Riggs, J.E.; Warehime, S.S.; Christie, I.; Ganser, G.; Van Dyke, K. Diabetes, 2002, 51, 2817-2825.
45. Bai, P.; Mabley, J.G.; Liaudet, L.; Virag, L.; Szabo, C.; Pacher, P. Oncology Reports, 2004, 11(2), 505-509.
46. Coppey, L.J.; Gellett, J.S.; Davidson, E.P.; Yorek, M.A. Free Radic. Res., 2003, 37(1), 33-40.
47. Poladia, D.P.; Bauer, J.A. Diabetes Metab. Res. Rev., 2003, 19(4), 313-319.
48. Pacher, P.; Szabo, C. Antioxidants & Redox Signaling, in press 2005.
49. Szabo, C. Toxicol Lett., 2003, 140-141, 105-112.
50. Suarez-Pinzon, WL.; Mabley, J.G.; Strynadka, K.; Power, R.F.; Szabo, C.; Rabinovitch, A. J. Autoimmun., 2001, 16(4), 449-455.
51. Furchgott, R.F. Biosci. Rep., 1999, 19, 235-251.
52. Caballero, A.E.; Arora, S.; Saouaf, R.; Lim, S.C.; Smakowski, P.; Park, J.Y.; King, G.L., LoGerfo, F.W,; Horton, E.S.; Veves, A. Diabetes, 1999, 48, 1856-1862.
53. Cai, H.; Harrison, D.G. Circ. Res., 2000, 87 840-844.
54. Cai, H.; Griendling, K.K.; Harrison, D.G. Trends Pharmacol. Sci., 2003, 24, 471-478.
55. Calles-Escandon, J.; Cipolla, M. Endocr. Rev., 2001 22, 36-52.
56. Cosentino, F.; Hishikawa, K.; Katusic, Z.S.; Luscher, T.F. Circulation, 1997, 96, 25-28.
57. Cosentino, F.; Luscher, T.F. J. Cardiovasc Pharmacol., 1998, 32, S54-61.
58. Beckman, J.A. Circ. Res., 2002, 90, 107-111.
59. De Vriese, A.S.; Verbeuren, T.J.; Van de Voorde, J.; Lameire, N.H., Vanhoutte, P.M. Br. J. Pharmacol., 2000, 130, 963-974.
60. Guzik, T.J., Mussa, S.; Gastaldi, D.; Sadowski, J.; Ratnatunga, C.; Pillai, R.; Channon, K.M. Circulation, 2002, 105, 1656-1662.
61. Guzik, T.J.; West, N.E.; Black, E.; McDonald, D.; Ratnatunga, C.; Pillai, R.; Channon, K.M. Circ. Res., 2000, 86, 85-90.
62. Kocsis, E.; Pacher, P.; Posa, I.; Nieszner, E.; Pogatsa, G.; Koltai, M.Z. Acta Physiol. Scand., 2000, 169(3), 183-187.
63. Ungvari, Z.; Pacher, P.; Kecskemeti, V.; Papp, G.; Szollar, L.; Koller, A. Cardiovasc. Res., 1999, 43(4), 1018-1028.
64. Nishikawa, T.; Edelstein, D.; Du, X.L.; Yamagishi, S.; Matsumura, T.; Kaneda, Y.; Yorek, M.A.; Beebe, D.; Oates, P.J.; Hammes, H.P.; Giardino, I.; Brownlee, M. Nature, 2000, 404, 787-790.
65. Giugliano, D.; Ceriello, A.; Paolisso, G. Diabetes Care 1996, 19, 257-267.
66. Spitaler, M.M.; Graier, W.F. Diabetologia, 2002, 45, 476-494.
67. Beckman, J.S.; Koppenol, W.H. Am. J. Physiol., 1996 271, 1424-1437.
68. Eiserich, J.P.; Hristova, M.; Cross, C.E.; Jones, A.D.; Freeman, B.A.; Halliwell, B.; et al. Nature, 1998, 391, 393-397.
69. Halliwell, B. FEBS. Lett., 1997, 411, 157-160.
70. Pennathur, S.; Wagner, J.D.; Leeuwenburgh, C.; Litwak, N.; Heinecke, J.W. J. Clin. Invest., 2001, 107, 853-860.
71. Mihm, M.J.; Jing, L.; Bauer, J.A. J. Cardiovasc. Pharmacol., 2000, 36(2), 182-187.
72. Bell, DS. Diabetes Care, 2003, 26(8), 2433-2441.
73. Bui, B.V.; Armitage, J.A.; Tolcos, M.; Cooper, M.E.; Vingrys, A.J. Diabetologia, 2003, 46(3), 401-408.
74. Lewis, E.J.; Lewis, J.B. Clin. Exp. Nephrol., 2003 7, 1-8.
75. Mihm, M.J.; Wattanapitayakul, S.K.; Piao, S.F.; Hoyt, D.G.; Bauer, J.A. Biochem. Pharmacol., 2003, 65, 1189-1197.
76. Szabó, C.; Pacher, P.; Komjati, K.; Mabley, J.G.; Benko, R.; Kollai, M. FASEB J., 2003, 17, A803.
77. Szabó, C.; Pacher, P.; Zsengellér, Z.; Vaslin, A.; Komjáti, K.; Benkö, R.; Mabley, J.G.; Kollai, M. Mol. Med., 2004 in press.
78. Bell, D.S. Diabetes Care, 1995, 18, 708-714.
79. Fein, F.S. Diabetes Care, 1990, 13, 1169-1179.
80. Illan, F.; Valdes-Chavarri, M.; Tebar, J.; Garcia, A.; Pascual, H.; Soria, F.; Hernandez, A.; Vicente, T. Clin. Invest., 1992, 70, 403-410.
81. Joffe, II.; Travers, K.E.; Perreault-Micale, C.L.; Hampton, T.; Katz, S.E.; Morgan, J.P, Douglas, P.S. J. Am. Coll. Cardiol., 1999, 34, 2111-2119.
82. Regan, T.J.; Ahmed, S.; Haider, B.; Moschos, C.; Weisse, A. N. Engl. J. Med., 1994, 91, 776- 778.
83. Dhalla, N.S.; Liu, X.; Panagia, V.; Takeda, N. Cardiovasc. Res., 1998, 40, 239-247.
84. Esberg, LB.; Ren, J. Diabetologia, 2003, 46 10), 1419-1427.
85. Mihm, M.J.; Coyle, C.M.; Schanbacher, B.L.; Weinstein, D.M.; Bauer, J.A. Cardiovasc. Res., 2001, 49, 798-807.
86. Pacher, P.; Liaudet, L.; Bai, P.; Mabley, J.G.; Kaminski, P.M.; Virag, L.; Deb, A.; Szabo, E.; Ungvari, Z.; Wolin, M.S.; Groves, J.T.; Szabo, C. Circulation, 2003, 107, 896-904.
87. Bianchi, C.; Wakiyama, H.; Faro, R.; Khan, T.; McCully, J.D.; Levitsky, S.; Szabo, C.; Sellke, FW. Ann. Thorac. Surg., 2002 74, 1201-1207.
88. Mihm, M.J.; Bauer, J.A. Biochimie, 2002, 84, 1013-1019.
89. Pacher, P.; Liaudet, L.; Bai, P.; Virag, L.; Mabley, J.; Hasko, G.; Szabo, C. J. Pharmacol. Exp. Ther., 2002, 300 862-687.
90. Pacher, P.; Liaudet, L.; Mabley, J.; Komjati, K.; Szabo C. J. Am. Coll. Cardiol., 2002, 40, 1006-1016.
91. Weinstein, D.M.; Mihm, M.J.; Bauer, J.A. J. Pharmacol. Exp. Ther., 2000, 294, 396-401, 2000.
92. Du, Y.; Smith, M.A.; Miller, C.M.; Kern, T.S. J. Neurochem., 2002, 80, 771-779.
93. Cheng, C.; Zochodne, D.W. Diabetes, 2003, 52 2363-2371.
94. Obrosova, I.G. Curr. Diab. Rep., 2003, 3, 439-445.
95. Obrosova, I.G.; Mabley, J.G.; Zsengeller, Z.; Charniauskaya, T.; Abatan, O.I.; Groves J.T.; Szabó, C. FASEB J., in press, 2005.
96. Obrosova, I.G.; Pacher, P.; Szabo, C.; Zsengeller, Z.; Hirooka, H.; Stevens, M.J.; Yorek, M.A. Diabetes, in press, 2005
97. Virag, L, Szabo, C. Pharmacol. Rev., 2002, 54 375-429.
98. Ceriello, A.; Piconi, L.; Quagliaro, L.; Ros, R.D.; Marini, C.; Giugliano, D.; Szabo, C. FASEB. J. 2003, 17, A260.
99. Obrosova, I.G.; Li, F.; Abatan, O.I.; Komjáti, K.; Pacher, P.; Szabo, C.; Stevens, M.J. Diabetes, 2004, 53, 711-720.
100. Pacher, P.; Liaudet, L.; Soriano, F.G.; Mabley, J.G.; Szabó, É.; Szabó, C. Diabetes, 2002, 51, 514-521.
101. Reusch, J.E. J. Clin. Invest., 2003, 112 7), 986-988.
102. Soriano, F.G.; Mabley, J.G.; Pacher, P.; Liaudet, L.; Szabó, C. Circ. Res., 2001, 89, 684-691.
103. Soriano, F.G.; Virag, L.; Szabo, C. J. Mol. Med., 2001, 79, 437-448.
104. Minchenko, A.G.; Stevens, M.J.; White, L.; Abatan, O.I.; Komjáti, K.; Pacher, P.; Szabo, C.; Obrosova, I.G. FASEB. J., 2003, 17(11), 1514-1516.
105. Li, F.; Szabo, C.; Pacher, P.; Southan, G.J.; Abatan, O.I.; Charniauskaya, T.; Stevens, M.J.; Obrosova, I.G. Diabetologia, 2004, 47, 710-717.
106. Obrosova, I.G.; Minchenko, A.G.; Frank, R.N.; Seigel, G.M.; Zsengeller, Z.; Pacher, P.; Stevens, M.J.; Szabo, C. Int. J. Mol. Med. 2004, 14(1), 55-64.