Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 1, 2000, Pages 396-401

  Weinstein, David M ^a   Mihm, Michael John ^a   Bauer, John Anthony ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b 412 Riffe Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CREATINE KINASE; DOXORUBICIN; MUSCLE PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; ENERGY TRANSFER; HEART LEFT VENTRICLE FAILURE; HEART OUTPUT; HEART STROKE VOLUME; HEART VENTRICLE CONTRACTION; HEART VENTRICLE FUNCTION; HUMAN; M MODE ECHOCARDIOGRAPHY; MALE; MOUSE; NITRATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CREATINE KINASE; DOXORUBICIN; IMMUNOHISTOCHEMISTRY; MALE; MICE; MYOCARDIUM; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; TYROSINE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0033932346     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Adams V, Jiang H, Yu J, Mobius-Winkler S, Fiehn E, Linke A, Weigl C, Schuler G and Hambrecht R (1999) Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. J Am Coll Cardiol 33:959-965.
2. Baird MB, Hough JL and Sfeir GT (1993) Accumulation of malondialdehyde in mouse heart following acute dosing with Adriamycin is strain specific and unaffected by cardiac catalase status. Res Commun Chem Pathol Pharmacol 80:363-366.
3. Banerjee A, Grosso MA, Brown JM, Rogers KB and Whitman GJ (1991) Oxygen metabolite effects on creatine kinase and cardiac energetics after reperfusion. Am J Physiol 261:H590-H597.
4. Beckman J and Koppenol W (1996) Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol 271:C1424-C1437.
5. Blum RH and Carter SK (1974) Adriamycin: A new anticancer drug with significant clinical activity. Ann Intern Med 80:249-259.
6. Doroshow JH, Locker GY and Myers CE (1979) Experimental animal models of adriamycin cardiotoxicity. Cancer Treat Rep 63:855-860.
7. Dorr RT (1996) Cytoprotective agents for anthracyclines. Semin Oncol 23:23-34.
8. Hasinoff BB (1998) Chemistry of dexrazoxane and analogues. Semin Oncol 25:3-9.
9. Haywood GA, Tsao PS, von der Leyen HE, Mann MJ, Keeling PJ, Trindade PT, Lewis NP, Byrne CD, Rickenbacher PR, Bishopric NH, Cooke JP, McKenna WJ and Fowler MB (1996) Expression of inducible nitric oxide synthase in human heart failure. Circulation 93:1087-1094.
10. Hortobagyi GN (1997) Anthracyclines in the treatment of cancer: An overview. Drugs 54:1-7.
11. Ingwall J, Kramer M, Fifer M, Lorell B, Shemin R, Grossman W and Allen P (1985) The creatine kinase system in normal and diseased myocardium. N Engl J Med 313:1050-1054.
12. Ischiropoulos H (1998) Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys 356:1-11.
13. Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F, Lee YC and Murad F (1998) An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci USA 95:11584-11589.
14. Kooy NW, Lewis SJ, Royall JA, Ye YZ, Kelly DR and Beckman JS (1997) Extensive tyrosine nitration in human myocardial inflammation: Evidence for the presence of peroxynitrite. Crit Care Med 25:812-819.
15. Kooy NW, Royall JA, Ye YZ, Kelly DR and Beckman JS (1995) Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 151:1250-1254.
16. Kowaltowski AJ and Vercesi AE (1999) Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 26:463-471.
17. MacMillan-Crow LA, Crow JP, Kerby JD, Beckman JS and Thompson JA (1996) Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci USA 93:11853-11858.
18. Mekhfi H, Veksler V, Mateo P, Maupoil V, Rochette L and Ventura-Clapier R (1996) Creatine kinase is the main target of reactive oxygen species in cardiac myofibrils. Circ Res 78:1016-1027.
19. Mihm MJ, Coyle CM, Jing L and Bauer JA (1999a) Vascular peroxynitrite formation during organic nitrate tolerance. J Pharmacol Exp Ther 291:194-198.
20. Mihm MJ, Weinstein DM and Bauer JA (1999b) Peroxynitrite induced nitration of myofibrillar creatine kinase: Implications in heart failure (Abstract). FASEB J 13:A753.
21. Miura T, Muraoka S and Ogiso T (1994) Adriamycin-Fe(3+)-induced inactivation of heart mitochondrial creatine kinase: Sensitivity to lipid peroxidation. Biol Pharm Bull 17:1220-1223.
22. Nagineni CN, Yamada T, Yang JJ and Serayderian MW (1985) Effects of adriamycin on enzymes of adenine nucleotide metabolism in heart cell cultures. Res Commun Chem Pathol Pharmacol 50:301-304.
23. Olson RD, Boerth HC, Gerber JG and Nies AS (1981) Mechanism of Adriamycin cardiotoxicity: Evidence for oxidative stress. Life Sci 29:1393-1401.
24. Sampson JB, Ye YZ, Rosen H and Beckman JS (1998) Myeloperoxidase and horse-radish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide. Arch Biochem Biophys 356:207-213.
25. Sarvazyan NA, Askari A and Huang WH (1995) Effects of doxorubicin on cardiomyocytes with reduced level of superoxide dismutase. Life Sci 57:1003-1010.
26. Singal PK (1987) Subcellular effects of Adriamycin in the heart: A concise review. J Mol Cell Cardiol 19:817-828.
27. Sokolovsky M, Riordan JF and Vallee BL (1966) Tetranitromethane: A reagent for the nitration of tyrosyl residues in proteins. Biochemistry 5:3582-3589.
28. Stamler JS, Singel DJ and Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science (Wash DC) 258:1898-1901.
29. Swain SM (1998) Adult multicenter trials with dexrazoxane in amelioration of doxorubicin and epirubicin-induced cardiotoxicity. Semin Oncol 25:43-47.
30. van der Vijgh WJ, Maessen PA and Pinedo HM (1990) Comparative metabolism and pharmacokinetics of doxorubicin and 4′-epidoxorubicin in plasma, heart and tumor of tumor-bearing mice. Cancer Chemother Pharmacol 26:9-12.
31. Varin R, Mulder P, Richard V, Tamion F, Devaux C, Henry JP, Lallemand F, Lerebours G and Thuillez C (1999) Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure: Role of nitric oxide, prostanoids, and oxidant stress. Circulation 99:2951-2957.
32. Vejlstrup NG, Bouloumie A, Boesgaard S, Andersen CB, Nielsen-Kudsk JE, Mortensen SA, Kent JD, Harrison DG, Busse R and Aldershvile J (1998) Inducible nitric oxide synthase (iNOS) in the human heart: Expression and localization in congestive heart failure. J Mol Cell Cardiol 30:1215-1223.
33. Ventura-Clapier R, Saks VA, Vassort G, Lauer C and Elizarova GV (1987) Reversible MM-creatine kinase binding to cardiac myofibrils. Am J Physiol 253:C444-C455.
34. Yen HC, Oberley TD, Vichitbandha S, Ho YS and St Clair DK (1996) The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 99:1253-1260.