Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells

Diabetes

Volumn 46, Issue 5, 1997, Pages 907-911

  Suarez Pinzon, Wilma L ^a   Szabó, Csaba ^b   Rabinovitch, Alex ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXYNITRITE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; DIABETES MELLITUS; ETIOLOGY; FEMALE; MOUSE; NONHUMAN; OXIDATION; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0030987135     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.5.907     Document Type: Article

References (29)

1. Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516-542, 1994
2. Castano L, Eisenbarth GS: Type-I diabetes: a chronic autoimmune disease of human, mouse and rat. Ann Rev Immunol 8:647-679, 1990
3. Mandrup-Poulsen T, Helqvist S, Wogensen LD, Møvig J, Pociot F, Johannesen J, Nerup J: Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol 164:169-193, 1990
4. Rabinovitch A: Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev 1:215-240, 1993
5. Corbett JA, McDaniel ML: Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41:897-903, 1992
6. Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerström C, Andersson A: Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proc Natl Acad Sci USA 91:9253-9266, 1994
7. Corbett JA, McDaniel ML: Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase. J Exp Med 181:559-568, 1995
8. Kleemann R, Rothe H, Kolb-Bachofen V, Xie Q, Nathan C, Martin S, Kolb H: Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett 328:9-12, 1993
9. Rothe H, Faust A, Schade U, Kleemann R, Bosse G, Hibino T, Martin S, Kolb H: Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Didbetologia 37:1154-1158, 1994
10. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC: Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS-expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137:2093-2099, 1996
11. Beckman J, Beckman T, Chen J, Marshall P, Freeman B: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc NaltlAcad Sci USA 87:1620-1624, 1990
12. Pryor WA, Squadrito GL: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with Superoxide. Am J Physiol 268:L699-L722, 1995
13. Kaur H, Halliwell B: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation: nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett 350:9-12, 1994
14. Szabó C, Salzman AL, Ischiropoulos H: Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett 363:235-238, 1995
15. Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372:229-232, 1995
16. Miller MJ, Thompson JH, Zhang XJ, Sadowska-Krowicka H, Kakkis JL, Munshi UK, Sandoval M, Rossi JL, Eloby-Childress S, Beckman JS, Ye YZ, Rodi CP, Manning P, Currie M, Clark DA: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig isleitis. Gastroenterology 109:1475-1483, 1995
17. Szabó C: The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6:79-88, 1996
18. Crow JP, Beckman JS: The role of peroxynitrite in nitric oxide-mediated toxicity. Curr Top Microbiol Immunol 196:57-73, 1995
19. Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL: Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 394:300-306, 1996
20. Gotoh M, Maki J, Kiyoizumi T, Satomi S, Monaco AP: An improved method for isolation of mouse pancreatic islets. Transplantation 40:437-438, 1985
21. Alejandro R, Shienvold FL, Vaerewyck Hajek SA, Pierce M, Paul R, Mintz DH: A ganglioside antigen on the rat pancreatic β cell surface identified by monoclonal antibody R2D6. J Clin Invest 74:25-38, 1984
22. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS: Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298:431-437, 1992
23. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power KF: IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol 154:4874-4882, 1995
24. Szabó C, Zingarelli B, O'Connor M, Salzman AL: DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93:1753-1758, 1996
25. Szabó C: DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic Biol Med 21:855-869, 1996
26. Uchigata Y, Yamamoto H, Kawamura A, Okamoto H: Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan-and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem 257:6084-6088, 1982
27. Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML: Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem Biophys Res Commun 197:1458-1464, 1993
28. Kwon NS, Lee SH, Choi CS, Kho T, Lee HS: Nitric oxide generation from streptozotocin. FASEB J 8:529-533, 1994
29. Heller B, Wang ZQ, Wagner EF, Radons J, Burkle A, Fehsel K, Burkart V, Kolb H: Inactivation of the poly (ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 270:11176-11180, 1995