High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: Role of protein kinase C and reactive oxygen species

Circulation

Volumn 107, Issue 7, 2003, Pages 1017-1023

  Cosentino, Francesco ^a,b,c,e   Eto, Masato ^a   De Paolis, Paola ^b,c   Van der Loo, Bernd ^a   Bachschmid, Markus ^d   Ullrich, Volker ^d   Kouroedov, Alexei ^a   Gatti, Chiara Delli ^a   Joch, Hana ^a   Volpe, Massimo ^b,c   Lüscher, Thomas F ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

^d UNIVERSITY OF KONSTANZ   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Diabetes mellitus; Nitric oxide; Stress

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CALPHOSTIN C; CYCLOOXYGENASE 2; GLUCOSE; INDOMETACIN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PHORBOL ESTER; PROSTACYCLIN SYNTHASE; PROSTANOID; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; TYROSINE;

AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MOLECULAR MECHANICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; ISOENZYMES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NADPH OXIDASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; THROMBOXANE A2; TYROSINE; UP-REGULATION;

EID: 0037465359     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000051367.92927.07     Document Type: Article

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