Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy

Diabetologia

Volumn 47, Issue 4, 2004, Pages 710-717

  Li, F ^a   Szabo C ^b,c   Pacher, P ^b,d,e   Southan, G J ^b   Abatan, O I ^a   Charniauskaya, T ^a   Stevens, M J ^a   Obrosova, I G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b INOTEK CORPORATION   (United States)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Energy state; Motor and sensory nerve conduction; Nerve blood flow; Oxidative and nitrosative stress; Peripheral diabetic neuropathy; PJ34; Poly(ADP ribose) polymerase; Rat; Sorbitol pathway of glucose metabolism; Streptozotocin diabetes

Indexed keywords

CREATINE; CREATINE PHOSPHATE; GLUCOSE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; POLY(ADENOSINE DIPHOSPHATE RIBOSE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CELL LEVEL; CONDUCTANCE; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DIABETIC NEUROPATHY; DRUG SCREENING; ENDONEURIUM; GLUCOSE BLOOD LEVEL; HYDROGEN CLEARANCE; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRION; MOTOR NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSORY NERVE CONDUCTION; SPECTROFLUOROMETRY; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DIURETICS; ENZYME INHIBITORS; MALE; MOTOR NEURONS; NAD; NEURAL CONDUCTION; NEURONS, AFFERENT; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; SCIATIC NEUROPATHY; SORBITOL;

EID: 2442651710     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1356-0     Document Type: Article

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