Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes

Diabetologia

Volumn 46, Issue 10, 2003, Pages 1419-1427

  Esberg, L B ^a   Ren, J ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Contraction; Glucose; Nitric oxide; NOS; Peroxynitrite; Tetrahydrobiopterin

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; GLUCOSE; GUANOSINE TRIPHOSPHATE CYCLOHYDROXYLASE I INHIBITOR; HEMOGLOBIN; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGEN; PEROXYNITRITE; PORPHYRIN DERIVATIVE; RECEPTOR BLOCKING AGENT; SCAVENGER; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; URATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; EVALUATION; HEART CONTRACTION; HEART DISEASE; HEART VENTRICLE CONTRACTION; MALE; MUSCLE CELL; MUSCLE STRENGTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TOXICITY;

ANIMALS; BIOPTERIN; CALCIUM; CELLS, CULTURED; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLUCOSE; INTRACELLULAR MEMBRANES; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; VENTRICULAR DYSFUNCTION;

EID: 0142125202     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1183-8     Document Type: Article

References (43)

1. Sowers JR, Epstein M (1995) Diabetes mellitus and associated hypertension, vascular disease and nephropathy: an update. Hypertension 26:869-879
2. Galderisi M, Anderson KM, Wilson PWF, Levy D (1991) Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol 68:85-89
3. Ren J, Davidoff AJ (1997) Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am J Physiol Heart Circ Physiol 272:H148-H158
4. 2+] and pH in rat skinned cardiac myocytes. Am J Physiol Heart Circ Physiol 269:H1656-H1663
5. 2+ handling in ventricular myocytes isolated from diabetic rats. Am J Physiol Heart Circ Physiol 270:H1529-H1537
6. 2+ exchanger activity in the diabetic heart. Cardiovasc Res 34:129-136
7. Kojda G, Harrison D (1999) Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 43:562-571
8. Ren J, Esberg LB, Combs CK, Ren BH, Chen AF (2001) Adenovirus gene transfer of recombinant endothelial nitric oxide synthase alters contractile function in isolated ventricular myocyte via a phosphatidylinositol 3-kinase-dependent pathway. Circulation 104:II-436 (Abstract)
9. Schultz R, Panas DL, Catena R, Moncada S, Olley PM, Lopaschuk GD (1995) The role of nitric oxide in cardiac depression induced by interleukin-1β and tumor necrosis factor-α. Br J Pharmacol 114:27-34
10. Nickola MW, Wold LE, Colligan PB, Wang GJ, Samson WK, Ren J (2000) Leptin attenuates cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Hypertension 36:501-505
11. Hibbs JB Jr, Taintor RR, Vavrin Z, Granger DL, Drapier J-C, Amber J, Lancaster JR Jr (1990) Synthesis of nitric oxide from a terminal guanidine nitrogen atom of L-arginine: a molecular mechanism regulating cellular proliferation that targets intracellular iron. In: Moncada S, Higgs EA (eds) Nitric oxide from L-arginine: a bioregulatory system. Excerpta Medica, Amsterdam, pp 189-224
12. Schulz R, Dodge KL, Lopaschuk GD, Clanachan AS (1997) Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency. Am J Physiol Heart Circ Physiol 272:H1212-H1219
13. Gutierrez HH, Nieves B, Chumley P, Rivera A, Freeman BA (1996) Nitric oxide regulation of superoxide-dependent lung injury: oxidant-protective actions of endogenously produced and exogenously administered nitric oxide. Free Rad Biol Med 21:43-52
14. Goda N, Suematsu M, Mukai M, Kiyokawa K, Natori M, Nozawa S, Ishimura Y (1996) Modulation of mitochondrion-mediated oxidative stress by nitric oxide in human placental trophoblastic cells. Am. J. Physiol. Heart Circ Physiol 271:H1893-H1899
15. Rösen P, Du X, Tschope D (1998) Role of oxygen derived radicals for vascular dysfunction in the diabetic heart: prevention by alpha-tocopherol? Mol Cell Biochem 188:103-111
16. Rösen P, Ballhausen Th, Stockklauser K (1996) Impairment of endothelium dependent relaxation in the diabetic rat heart: mechanisms and implications. Diabetes Res Clin Pract 31:S143-S155
17. Pieper GM (1998) A review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction. Hypertension 31:1047-1060
18. Stockklauser-Farber K, Ballhausen T, Laufer A, Rosen P (2000) Influence of diabetes on cardiac nitric oxide synthase expression and activity. Biochim Biophys Acta 1535: 10-20
19. Hintz KK, Wold LE, Colligan PB, Scott GI, Lee KJ, Sowers JR, Ren J (2001) Influence of ovariectomy on ventricular myocyte contraction in simulated diabetes. J Biomed Sci 8:307-313
20. Bagi Z, Koller A (2003) Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. J Vasc Res 40:47-57
21. Meininger CJ, Marinos RS, Hatakeyama K, Martinez-Zaguilan R, Rojas JD, Kelly KA, Wu G (2000) Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J 349:353-356
22. Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG (2001) Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103:1282-1288
23. Ren J, Dominguez LJ, Sowers JR, Davidoff AJ (1996) Troglitazone attenuates high glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes. Diabetes 45:1822-1825
24. Ren J, Gintant GA, Miller RE, Davidoff AJ (1997) High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner. Am J Physiol Heart Circ Physiol 273:H2876-H2883
25. Davidoff AJ, Ren J (1997) Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Am J Physiol Heart Circ Physiol 272:H159-H167
26. Norby FL, Wold LE, Duan J, Hintz KK, Ren J (2002) IGF-I attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes. Am J Physiol Endocrinol Metab 283:E658-E666
27. Barbagallo M, Shan J, Pang PK, Resnick LM (1995) Glucose-induced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells. J Clin Invest 95:763-767
28. i of cardiac myocytes. Kidney Int 53:1237-1243
29. Yuan SY, Ustinova EE, Wu MH, Tinsley JH, Xu W, Korompai FL, Taulman AC (2000) Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes. Circ Res 87:412-417
30. Colligan PB, Relling DP, Ren J (2202) Ceramide reduces high glucose-induced diabetic cardiomyopathy in adult rat ventricular myocytes. Cell Mol Biol 48:OL251-OL257
31. Kolb H, Kiesel U, Kroncke KD, Kolb-Bachofen V (1991) Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci 49:PL213-PL217
32. Papaccio G, Esposito V, Latronico MV, Pisanti FA (1995) Administration of a nitric oxide synthase inhibitor does not suppress low-dose streptozotocin-induced diabetes in mice. Int J Pancreatol 17:63-68
33. Smith JM, Paulson DJ, Romano FD (1997) Inhibition of nitric oxide synthase by L-NAME improves ventricular performance in streptozotocin-diabetic rats. J Mol Cell Cardiol 29:2393-2402
34. Cosentino F, Hishikawa K, Katusic ZS, Lüscher TF (1997) High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 96:25-28
35. Graier WF, Simecek S, Kukovetz WR, Kostner GM (1996) High D-glucose-induced changes in endothelial Ca2+/ EDRF signaling are due to generation of superoxide anions. Diabetes 45:1386-1395
36. Balon, TW, Nadler JL (1997) Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 82:359-363
37. Trachtman, H, Futterweit S, Crimmins DL (1997) High glucose inhibits nitric oxide production in cultured rat mesangial cells. J Am Soc Nephrol 8:1276-1282
38. Felaco M, Grilli A, De Lutiis MA, Patruno A, Libertini N, Taccardi AA, Di Napoli P, Di Giulio C, Barbacane R, Conti P (2001) Endothelial nitric oxide synthase (eNOS) expression and localization in healthy and diabetic rat hearts. Ann Clin Lab Sci. 31:179-186
39. 2+-ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E. Biochim Biophys Acta 1588:71-78
40. Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zhou YS, Pinsky D, Stern D (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269:9889-9897
41. Giardino I, Edelstein D, Brownlee M (1996) BCL-2 expression or antioxidants prevent hyperglycaemia-induced formation of intracellular advanced glycation end-products in bovine endothelial cells. J Clin Invest 94:110-117
42. Tannous M, Rabini RA, Vignini A, Moretti N, Fumelli P, Zielinski B, Mazzanti L, Mutus B (1999) Evidence for iNOS-dependent peroxynitrite production in diabetic platelets. Diabetologia 42:539-544
43. Pieper GM (1997) Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiovasc Pharmacol 29:8-15