Inhibition of protein kinase Cβ prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

Circulation Research

Volumn 90, Issue 1, 2002, Pages 107-111

  Beckman, Joshua A ^a   Goldfine, Allison B ^a   Gordon, Mary Beth ^a   Garrett, Leslie A ^a   Creager, Mark A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Diabetes; Endothelium; Hyperglycemia; Nitric oxide; Protein kinase C

Indexed keywords

9 [(DIMETHYLAMINO)METHYL] 6,7,10,11 TETRAHYDRO 9H,18H 5,21; GLUCOSE; METHACHOLINE CHLORIDE; NITRIC OXIDE; PLACEBO; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRACHIAL ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETES MELLITUS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; IN VIVO STUDY; MALE; NORMAL HUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STRAIN GAUGE TRANSDUCER; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASODILATATION; VEIN OCCLUSION;

ADULT; BLOOD FLOW VELOCITY; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMALE; FOREARM; HUMANS; HYPERGLYCEMIA; INDOLES; ISOENZYMES; MALE; MALEIMIDES; METHACHOLINE CHLORIDE; PROTEIN KINASE C; VASODILATION;

EID: 0037059549     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0102.102359     Document Type: Article

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